IL119971A - Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids - Google Patents
Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acidsInfo
- Publication number
- IL119971A IL119971A IL11997197A IL11997197A IL119971A IL 119971 A IL119971 A IL 119971A IL 11997197 A IL11997197 A IL 11997197A IL 11997197 A IL11997197 A IL 11997197A IL 119971 A IL119971 A IL 119971A
- Authority
- IL
- Israel
- Prior art keywords
- dicarboxylic acids
- pharmaceutical compositions
- derivatives
- compositions containing
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/602—Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11997197A IL119971A (en) | 1997-01-07 | 1997-01-07 | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
KR1019997006147A KR100806928B1 (ko) | 1997-01-07 | 1997-12-25 | 카르복실산, 그의 유도체 및 이들을 함유하는 약학적 조성물 |
JP53069798A JP2001507713A (ja) | 1997-01-07 | 1997-12-25 | カルボン酸及びその誘導体及びそれらを含む薬剤組成物 |
AU79947/98A AU742945B2 (en) | 1997-01-07 | 1997-12-25 | Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them |
AT97949080T ATE431816T1 (de) | 1997-01-07 | 1997-12-25 | Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten |
CA2277075A CA2277075C (fr) | 1997-01-07 | 1997-12-25 | Acides carboxyliques et leurs derives, et compositions pharmaceutiques les contenant |
EP97949080A EP0988274B1 (fr) | 1997-01-07 | 1997-12-25 | Acides carboxyliques et leurs derives, et compositions pharmaceutiques les contenant |
PCT/IL1997/000427 WO1998030530A1 (fr) | 1997-01-07 | 1997-12-25 | Acides carboxyliques et leurs derives, et compositions pharmaceutiques les contenant |
EP09160514.7A EP2112134B1 (fr) | 1997-01-07 | 1997-12-25 | Acides carboxyliques et dérivés associés et compositions pharmaceutiques les contenant |
US09/331,895 US6284903B1 (en) | 1997-01-07 | 1997-12-25 | Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
KR1020077003601A KR100806927B1 (ko) | 1997-01-07 | 1997-12-25 | 카르복실산, 그의 유도체 및 이들을 함유하는 약학적조성물 |
DE69739415T DE69739415D1 (de) | 1997-01-07 | 1997-12-25 | Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten |
US09/881,812 US6800772B2 (en) | 1997-01-07 | 2001-06-18 | Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
US10/680,429 US20040132818A1 (en) | 1997-01-07 | 2003-10-08 | Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
JP2009260665A JP5479857B2 (ja) | 1997-01-07 | 2009-11-16 | カルボン酸及びその誘導体及びそれらを含む薬剤組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11997197A IL119971A (en) | 1997-01-07 | 1997-01-07 | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
IL119971A0 IL119971A0 (en) | 1997-04-15 |
IL119971A true IL119971A (en) | 2003-02-12 |
Family
ID=11069666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11997197A IL119971A (en) | 1997-01-07 | 1997-01-07 | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
Country Status (10)
Country | Link |
---|---|
US (3) | US6284903B1 (fr) |
EP (2) | EP2112134B1 (fr) |
JP (2) | JP2001507713A (fr) |
KR (2) | KR100806927B1 (fr) |
AT (1) | ATE431816T1 (fr) |
AU (1) | AU742945B2 (fr) |
CA (1) | CA2277075C (fr) |
DE (1) | DE69739415D1 (fr) |
IL (1) | IL119971A (fr) |
WO (1) | WO1998030530A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303653B1 (en) | 1997-06-26 | 2001-10-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6814962B1 (en) * | 1994-06-02 | 2004-11-09 | Aventis Pharma S.A. | Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same |
IL119971A (en) * | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
ATE384035T1 (de) | 1999-04-01 | 2008-02-15 | Esperion Therapeutics Inc | Ether-verbindungen, zusammensetzungen und ihre verwendung |
CN1283610C (zh) | 2000-10-11 | 2006-11-08 | 埃斯佩里安医疗公司 | 用于控制胆固醇以及相关用途的酮化合物以及组合物 |
CA2425674A1 (fr) | 2000-10-11 | 2002-04-18 | Jean-Louis H. Dasseux | Composes et compositions de sulfure et de disulfure pour le traitement du cholesterol et utilisations associees |
CA2425678A1 (fr) | 2000-10-11 | 2002-04-18 | Jean-Louis H. Dasseux | Composes de sulfoxyde et de bis-sulfoxyde et compositions pour reguler le cholesterol, et applications associees |
US7304093B2 (en) | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
JP2004529069A (ja) | 2000-10-11 | 2004-09-24 | エスペリオン セラピューティクス,インコーポレイテッド | コレステロール管理用のエーテル化合物及び組成物ならびに関連する使用 |
BRPI0318046B8 (pt) * | 2003-01-23 | 2021-05-25 | Esperion Therapeutics Inc | compostos de hidroxila, seu usos, e composições farmacêuticas |
EP1701931B1 (fr) | 2003-12-24 | 2018-10-10 | Esperion Therapeutics, Inc. | Dérivés cétoniques, compositions pour maintenir le taux de cholèstèrol et leurs utilisations |
US20090018199A1 (en) * | 2003-12-30 | 2009-01-15 | Syndrome X Ltd. | Methods of Administering 3, 3, 14, 14 Tetramethyl Hexadecane 1, 16 Dioic Acid |
CN101365446B (zh) | 2005-07-29 | 2013-05-22 | 雷斯弗洛吉克斯公司 | 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送 |
JP5236664B2 (ja) | 2007-02-01 | 2013-07-17 | レスバーロジックス コーポレイション | 心血管疾患を予防および治療するための化合物 |
IL181577A0 (en) * | 2007-02-26 | 2007-07-04 | Jacob Bar Tana | Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders |
ATE530178T1 (de) | 2007-05-23 | 2011-11-15 | Amcol International Corp | Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger |
AU2009262252B2 (en) | 2008-06-26 | 2013-05-02 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
CA2747417C (fr) | 2009-01-08 | 2017-01-03 | Resverlogix Corp. | Composes pour la prevention et le traitement de maladies cardiovasculaires |
NZ708314A (en) | 2009-03-18 | 2017-08-25 | Resverlogix Corp | Quinazolinones for use as anticancer agents |
BRPI1014956B8 (pt) | 2009-04-22 | 2021-05-25 | Resverlogix Corp | agentes anti-inflamatórios |
NZ710626A (en) | 2009-09-03 | 2017-03-31 | Pfizer Vaccines Llc | Pcsk9 vaccine |
CA2812109A1 (fr) | 2010-09-20 | 2012-03-29 | Kareus Therapeutics, Sa | Procedes et compositions pour le traitement du diabete et de la dyslipidemie |
US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
CA2851996C (fr) | 2011-11-01 | 2020-01-07 | Resverlogix Corp. | Compositions pharmaceutiques pour des quinazolinones substituees |
US10479752B2 (en) * | 2011-12-08 | 2019-11-19 | Syndromex Ltd. | Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof |
WO2014080290A2 (fr) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Amines cycliques servant d'inhibiteurs de bromodomaines |
WO2014080291A2 (fr) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Dérivés biaryle servant d'inhibiteurs de bromodomaines |
MX2015007921A (es) | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Compuestos heterociclicos novedosos como inhibidores de bromodominio. |
WO2015123291A1 (fr) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Vaccin à base de pcsk9 et méthodes d'utilisation dudit vaccin |
KR102370582B1 (ko) | 2015-03-13 | 2022-03-04 | 에스페리온 테라피유틱스 인코포레이티드 | Etc1002 및 에제티미브를 포함하는 고정 용량 조합 및 제형 및 심혈관 질환의 치료 또는 이의 위험의 감소 방법 |
JP6903585B2 (ja) | 2015-03-13 | 2021-07-14 | レスバーロジックス コーポレイション | 補体関連疾患の治療のための組成物および治療方法 |
MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
CN107118098B (zh) * | 2016-02-25 | 2020-07-14 | 中国科学院上海药物研究所 | 一类脂肪酸类化合物、其制备方法及其用途 |
EP3463330B1 (fr) * | 2016-06-02 | 2022-05-04 | Syndromex Ltd. | Régime de traitement du diabète utilisant des carboxylates amphipathiques à longue chaîne alpha, alpha-substitués |
US10512624B2 (en) | 2016-11-30 | 2019-12-24 | Syndromex Ltd. | Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1 |
US20230141635A1 (en) | 2019-06-21 | 2023-05-11 | Esperion Therapeutics, Inc. | Salt forms of bempedoic acid and methods for using the same |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1268082A (en) | 1969-08-08 | 1972-03-22 | Orsymonde | Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes |
US3930024A (en) * | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
BE755550A (fr) * | 1969-09-02 | 1971-02-01 | Parke Davis & Co | Acides alcanedioiques, leurs sels et leurs esters abaissant la teneur en triglycerides du serum sanguin |
US3773946A (en) | 1969-09-02 | 1973-11-20 | Parke Davis & Co | Triglyceride-lowering compositions and methods |
FR2288516A2 (fr) | 1974-10-21 | 1976-05-21 | Orsymonde | Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives |
IL64542A0 (en) | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
DE3423166A1 (de) | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
US4634975A (en) * | 1984-09-17 | 1987-01-06 | Progressive Dynamics, Inc. | Method and apparatus for producing electromagnetic surveillance fields |
JPS61171417A (ja) * | 1985-01-23 | 1986-08-02 | Wakunaga Seiyaku Kk | 抗糖尿病剤 |
DE3512536A1 (de) * | 1985-04-06 | 1986-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3634356A1 (de) * | 1986-10-08 | 1988-04-21 | Epis Sa | Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren |
DE4224670A1 (de) * | 1992-07-25 | 1994-01-27 | Boehringer Mannheim Gmbh | Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker |
US5648387A (en) * | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
IL119971A (en) * | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
JP2003001549A (ja) * | 2001-06-26 | 2003-01-08 | Howa Mach Ltd | 光電式刃具折れ検知装置 |
-
1997
- 1997-01-07 IL IL11997197A patent/IL119971A/xx not_active IP Right Cessation
- 1997-12-25 US US09/331,895 patent/US6284903B1/en not_active Expired - Lifetime
- 1997-12-25 JP JP53069798A patent/JP2001507713A/ja not_active Withdrawn
- 1997-12-25 CA CA2277075A patent/CA2277075C/fr not_active Expired - Fee Related
- 1997-12-25 EP EP09160514.7A patent/EP2112134B1/fr not_active Expired - Lifetime
- 1997-12-25 KR KR1020077003601A patent/KR100806927B1/ko not_active IP Right Cessation
- 1997-12-25 DE DE69739415T patent/DE69739415D1/de not_active Expired - Lifetime
- 1997-12-25 WO PCT/IL1997/000427 patent/WO1998030530A1/fr not_active Application Discontinuation
- 1997-12-25 AU AU79947/98A patent/AU742945B2/en not_active Ceased
- 1997-12-25 AT AT97949080T patent/ATE431816T1/de not_active IP Right Cessation
- 1997-12-25 KR KR1019997006147A patent/KR100806928B1/ko not_active IP Right Cessation
- 1997-12-25 EP EP97949080A patent/EP0988274B1/fr not_active Expired - Lifetime
-
2001
- 2001-06-18 US US09/881,812 patent/US6800772B2/en not_active Expired - Lifetime
-
2003
- 2003-10-08 US US10/680,429 patent/US20040132818A1/en not_active Abandoned
-
2009
- 2009-11-16 JP JP2009260665A patent/JP5479857B2/ja not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303653B1 (en) | 1997-06-26 | 2001-10-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
EP0988274A4 (fr) | 2000-10-18 |
JP5479857B2 (ja) | 2014-04-23 |
EP0988274B1 (fr) | 2009-05-20 |
EP2112134B1 (fr) | 2013-10-30 |
CA2277075A1 (fr) | 1998-07-16 |
KR20070026888A (ko) | 2007-03-08 |
US6284903B1 (en) | 2001-09-04 |
EP2112134A1 (fr) | 2009-10-28 |
AU7994798A (en) | 1998-08-03 |
KR20000069934A (ko) | 2000-11-25 |
ATE431816T1 (de) | 2009-06-15 |
CA2277075C (fr) | 2010-06-22 |
WO1998030530A1 (fr) | 1998-07-16 |
JP2001507713A (ja) | 2001-06-12 |
EP0988274A1 (fr) | 2000-03-29 |
US20020049345A1 (en) | 2002-04-25 |
IL119971A0 (en) | 1997-04-15 |
JP2010077141A (ja) | 2010-04-08 |
KR100806927B1 (ko) | 2008-02-22 |
AU742945B2 (en) | 2002-01-17 |
DE69739415D1 (de) | 2009-07-02 |
US20040132818A1 (en) | 2004-07-08 |
KR100806928B1 (ko) | 2008-02-22 |
US6800772B2 (en) | 2004-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |