IL119971A - Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids - Google Patents

Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Info

Publication number
IL119971A
IL119971A IL11997197A IL11997197A IL119971A IL 119971 A IL119971 A IL 119971A IL 11997197 A IL11997197 A IL 11997197A IL 11997197 A IL11997197 A IL 11997197A IL 119971 A IL119971 A IL 119971A
Authority
IL
Israel
Prior art keywords
dicarboxylic acids
pharmaceutical compositions
derivatives
compositions containing
novel
Prior art date
Application number
IL11997197A
Other languages
English (en)
Other versions
IL119971A0 (en
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL11997197A priority Critical patent/IL119971A/xx
Publication of IL119971A0 publication Critical patent/IL119971A0/xx
Priority to KR1020077003601A priority patent/KR100806927B1/ko
Priority to EP09160514.7A priority patent/EP2112134B1/fr
Priority to AU79947/98A priority patent/AU742945B2/en
Priority to AT97949080T priority patent/ATE431816T1/de
Priority to JP53069798A priority patent/JP2001507713A/ja
Priority to US09/331,895 priority patent/US6284903B1/en
Priority to EP97949080A priority patent/EP0988274B1/fr
Priority to KR1019997006147A priority patent/KR100806928B1/ko
Priority to DE69739415T priority patent/DE69739415D1/de
Priority to PCT/IL1997/000427 priority patent/WO1998030530A1/fr
Priority to CA2277075A priority patent/CA2277075C/fr
Priority to US09/881,812 priority patent/US6800772B2/en
Publication of IL119971A publication Critical patent/IL119971A/xx
Priority to US10/680,429 priority patent/US20040132818A1/en
Priority to JP2009260665A priority patent/JP5479857B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/602—Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11997197A 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids IL119971A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
CA2277075A CA2277075C (fr) 1997-01-07 1997-12-25 Acides carboxyliques et leurs derives, et compositions pharmaceutiques les contenant
US09/331,895 US6284903B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
KR1019997006147A KR100806928B1 (ko) 1997-01-07 1997-12-25 카르복실산, 그의 유도체 및 이들을 함유하는 약학적 조성물
AU79947/98A AU742945B2 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them
AT97949080T ATE431816T1 (de) 1997-01-07 1997-12-25 Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten
JP53069798A JP2001507713A (ja) 1997-01-07 1997-12-25 カルボン酸及びその誘導体及びそれらを含む薬剤組成物
KR1020077003601A KR100806927B1 (ko) 1997-01-07 1997-12-25 카르복실산, 그의 유도체 및 이들을 함유하는 약학적조성물
EP97949080A EP0988274B1 (fr) 1997-01-07 1997-12-25 Acides carboxyliques et leurs derives, et compositions pharmaceutiques les contenant
EP09160514.7A EP2112134B1 (fr) 1997-01-07 1997-12-25 Acides carboxyliques et dérivés associés et compositions pharmaceutiques les contenant
DE69739415T DE69739415D1 (de) 1997-01-07 1997-12-25 Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten
PCT/IL1997/000427 WO1998030530A1 (fr) 1997-01-07 1997-12-25 Acides carboxyliques et leurs derives, et compositions pharmaceutiques les contenant
US09/881,812 US6800772B2 (en) 1997-01-07 2001-06-18 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
US10/680,429 US20040132818A1 (en) 1997-01-07 2003-10-08 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
JP2009260665A JP5479857B2 (ja) 1997-01-07 2009-11-16 カルボン酸及びその誘導体及びそれらを含む薬剤組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Publications (2)

Publication Number Publication Date
IL119971A0 IL119971A0 (en) 1997-04-15
IL119971A true IL119971A (en) 2003-02-12

Family

ID=11069666

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Country Status (10)

Country Link
US (3) US6284903B1 (fr)
EP (2) EP2112134B1 (fr)
JP (2) JP2001507713A (fr)
KR (2) KR100806927B1 (fr)
AT (1) ATE431816T1 (fr)
AU (1) AU742945B2 (fr)
CA (1) CA2277075C (fr)
DE (1) DE69739415D1 (fr)
IL (1) IL119971A (fr)
WO (1) WO1998030530A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303653B1 (en) 1997-06-26 2001-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

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US6814962B1 (en) * 1994-06-02 2004-11-09 Aventis Pharma S.A. Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
US6506799B1 (en) 1999-04-01 2003-01-14 Esperion Therapeutics, Inc. Methods of treating cardiovascular diseases, dyslipidemia, dyslipoproteinemia, and hypertension with ether compounds
CN101426763A (zh) 2000-10-11 2009-05-06 埃斯佩里安医疗公司 用于胆固醇治疗和相关应用的硫化物和二硫化物化合物和组合物
AU2002213137A1 (en) 2000-10-11 2002-04-22 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
CA2425311C (fr) 2000-10-11 2011-06-14 Esperion Therapeutics, Inc. Composes de fonction cetone et compositions pour la regulation du taux de cholesterol, et utilisations associees
WO2002030882A2 (fr) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Composes de sulfoxyde et de bis-sulfoxyde et compositions pour reguler le cholesterol, et applications associees
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US7335799B2 (en) 2003-01-23 2008-02-26 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
CA2549995C (fr) 2003-12-24 2011-11-15 Esperion Therapeutics, Inc. Composes a fonction cetone et compositions pour le controle de cholesterol et utilisations associees
JP2007528369A (ja) * 2003-12-30 2007-10-11 シンドロメクス・リミテッド ３，３，１４，１４−テトラメチルヘキサデカン−１，１６−ジオイック酸の投与法
CA2617213C (fr) 2005-07-29 2014-01-28 Resverlogix Corp. Compositions pharmaceutiques pour la prevention et le traitement de maladies complexes et leur administration par des dispositifs medicaux inserables
US8053440B2 (en) 2007-02-01 2011-11-08 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular diseases
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
EP2167069B1 (fr) 2007-05-23 2011-10-26 Amcol International Corporation Phyllosilicates en couches interagissant avec le cholestérol et procédés visant à réduire l'hypercholestérolémie chez un mammifère
DK2346837T3 (en) 2008-06-26 2015-04-20 Resverlogix Corp Methods for preparing quinazolinone derivatives
EP2660238B1 (fr) 2009-01-08 2015-05-06 Resverlogix Corporation Composés pour la prévention et le traitement d'une maladie cardiovasculaire
CN105859639A (zh) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
PT2421533T (pt) 2009-04-22 2019-01-21 Resverlogix Corp Novos agentes anti-inflamatórios
MY163512A (en) 2009-09-03 2017-09-15 Pfizer Vaccines Llc Pcsk9 vaccine
SG188996A1 (en) 2010-09-20 2013-05-31 Kareus Therapeutics Sa Methods and compositions for treatment of diabetes and dyslipidemia
WO2012131504A1 (fr) 2011-03-02 2012-10-04 Pfizer Inc. Vaccin à base de pcsk9
EP2773354B1 (fr) 2011-11-01 2019-06-12 Resverlogix Corp. Compositions pharmaceutiques a la liberation immediate pour l'administration orale des quinazolinones substituées
EP2787986B1 (fr) 2011-12-08 2017-10-18 Syndromex Ltd. Acides dioïques de tétraméthyle deutérés, compositions les comprenant et leurs utilisations
WO2014080291A2 (fr) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Dérivés biaryle servant d'inhibiteurs de bromodomaines
WO2014080290A2 (fr) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Amines cycliques servant d'inhibiteurs de bromodomaines
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
EP3104877B1 (fr) 2014-02-11 2020-01-22 The USA, as represented by The Secretary, Department of Health and Human Services Vaccin à base de pcsk9 et méthodes d'utilisation dudit vaccin
MX2017011499A (es) 2015-03-13 2018-03-26 Esperion Therapeutics Inc Combinaciones de dosis fija y formulaciones que comprenden ácido 8-hidroxi-2,2,14,14 tetrametilpentadecanodioico (etc1002) y ezetimiba y métodos para tratar o reducir el riesgo de enfermedad cardiovascular.
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
CN109195595A (zh) * 2016-06-02 2019-01-11 塞多麦克斯有限公司 使用α，α-取代的长链两亲性羧酸盐的糖尿病治疗方案
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
MX2021015935A (es) 2019-06-21 2022-04-26 Esperion Therapeutics Inc Formas de sal de acido bempedoico y metodos para utilizar el mismo.

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GB1268082A (en) 1969-08-08 1972-03-22 Orsymonde Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
US3773946A (en) * 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
BE755550A (fr) * 1969-09-02 1971-02-01 Parke Davis & Co Acides alcanedioiques, leurs sels et leurs esters abaissant la teneur en triglycerides du serum sanguin
FR2288516A2 (fr) * 1974-10-21 1976-05-21 Orsymonde Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
IL64542A0 (en) 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
DE3423166A1 (de) 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4634975A (en) * 1984-09-17 1987-01-06 Progressive Dynamics, Inc. Method and apparatus for producing electromagnetic surveillance fields
JPS61171417A (ja) * 1985-01-23 1986-08-02 Wakunaga Seiyaku Kk 抗糖尿病剤
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3634356A1 (de) * 1986-10-08 1988-04-21 Epis Sa Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren
DE4224670A1 (de) * 1992-07-25 1994-01-27 Boehringer Mannheim Gmbh Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
JP2003001549A (ja) * 2001-06-26 2003-01-08 Howa Mach Ltd 光電式刃具折れ検知装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303653B1 (en) 1997-06-26 2001-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA2277075C (fr) 2010-06-22
AU7994798A (en) 1998-08-03
JP2001507713A (ja) 2001-06-12
KR100806927B1 (ko) 2008-02-22
EP0988274A1 (fr) 2000-03-29
AU742945B2 (en) 2002-01-17
US6284903B1 (en) 2001-09-04
EP2112134B1 (fr) 2013-10-30
EP2112134A1 (fr) 2009-10-28
ATE431816T1 (de) 2009-06-15
EP0988274A4 (fr) 2000-10-18
US20040132818A1 (en) 2004-07-08
KR20070026888A (ko) 2007-03-08
KR100806928B1 (ko) 2008-02-22
KR20000069934A (ko) 2000-11-25
JP5479857B2 (ja) 2014-04-23
US20020049345A1 (en) 2002-04-25
JP2010077141A (ja) 2010-04-08
WO1998030530A1 (fr) 1998-07-16
CA2277075A1 (fr) 1998-07-16
DE69739415D1 (de) 2009-07-02
US6800772B2 (en) 2004-10-05
EP0988274B1 (fr) 2009-05-20
IL119971A0 (en) 1997-04-15

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