IL119971A - Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids - Google Patents

Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Info

Publication number
IL119971A
IL119971A IL11997197A IL11997197A IL119971A IL 119971 A IL119971 A IL 119971A IL 11997197 A IL11997197 A IL 11997197A IL 11997197 A IL11997197 A IL 11997197A IL 119971 A IL119971 A IL 119971A
Authority
IL
Israel
Prior art keywords
dicarboxylic acids
pharmaceutical compositions
derivatives
compositions containing
novel
Prior art date
Application number
IL11997197A
Other languages
English (en)
Other versions
IL119971A0 (en
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL11997197A priority Critical patent/IL119971A/xx
Publication of IL119971A0 publication Critical patent/IL119971A0/xx
Priority to PCT/IL1997/000427 priority patent/WO1998030530A1/en
Priority to US09/331,895 priority patent/US6284903B1/en
Priority to AT97949080T priority patent/ATE431816T1/de
Priority to CA2277075A priority patent/CA2277075C/en
Priority to EP97949080A priority patent/EP0988274B1/en
Priority to JP53069798A priority patent/JP2001507713A/ja
Priority to EP09160514.7A priority patent/EP2112134B1/en
Priority to AU79947/98A priority patent/AU742945B2/en
Priority to KR1020077003601A priority patent/KR100806927B1/ko
Priority to DE69739415T priority patent/DE69739415D1/de
Priority to KR1019997006147A priority patent/KR100806928B1/ko
Priority to US09/881,812 priority patent/US6800772B2/en
Publication of IL119971A publication Critical patent/IL119971A/xx
Priority to US10/680,429 priority patent/US20040132818A1/en
Priority to JP2009260665A priority patent/JP5479857B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/602—Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11997197A 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids IL119971A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
KR1019997006147A KR100806928B1 (ko) 1997-01-07 1997-12-25 카르복실산, 그의 유도체 및 이들을 함유하는 약학적 조성물
JP53069798A JP2001507713A (ja) 1997-01-07 1997-12-25 カルボン酸及びその誘導体及びそれらを含む薬剤組成物
AU79947/98A AU742945B2 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them
AT97949080T ATE431816T1 (de) 1997-01-07 1997-12-25 Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten
CA2277075A CA2277075C (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
EP97949080A EP0988274B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
PCT/IL1997/000427 WO1998030530A1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
EP09160514.7A EP2112134B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
US09/331,895 US6284903B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
KR1020077003601A KR100806927B1 (ko) 1997-01-07 1997-12-25 카르복실산, 그의 유도체 및 이들을 함유하는 약학적조성물
DE69739415T DE69739415D1 (de) 1997-01-07 1997-12-25 Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten
US09/881,812 US6800772B2 (en) 1997-01-07 2001-06-18 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
US10/680,429 US20040132818A1 (en) 1997-01-07 2003-10-08 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
JP2009260665A JP5479857B2 (ja) 1997-01-07 2009-11-16 カルボン酸及びその誘導体及びそれらを含む薬剤組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Publications (2)

Publication Number Publication Date
IL119971A0 IL119971A0 (en) 1997-04-15
IL119971A true IL119971A (en) 2003-02-12

Family

ID=11069666

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Country Status (10)

Country Link
US (3) US6284903B1 (es)
EP (2) EP2112134B1 (es)
JP (2) JP2001507713A (es)
KR (2) KR100806927B1 (es)
AT (1) ATE431816T1 (es)
AU (1) AU742945B2 (es)
CA (1) CA2277075C (es)
DE (1) DE69739415D1 (es)
IL (1) IL119971A (es)
WO (1) WO1998030530A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303653B1 (en) 1997-06-26 2001-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

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US6814962B1 (en) * 1994-06-02 2004-11-09 Aventis Pharma S.A. Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
ATE384035T1 (de) 1999-04-01 2008-02-15 Esperion Therapeutics Inc Ether-verbindungen, zusammensetzungen und ihre verwendung
CN1283610C (zh) 2000-10-11 2006-11-08 埃斯佩里安医疗公司 用于控制胆固醇以及相关用途的酮化合物以及组合物
CA2425674A1 (en) 2000-10-11 2002-04-18 Jean-Louis H. Dasseux Sulfide and disulfide compounds and compositions for cholesterol management and related uses
CA2425678A1 (en) 2000-10-11 2002-04-18 Jean-Louis H. Dasseux Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
JP2004529069A (ja) 2000-10-11 2004-09-24 エスペリオン セラピューティクス，インコーポレイテッド コレステロール管理用のエーテル化合物及び組成物ならびに関連する使用
BRPI0318046B8 (pt) * 2003-01-23 2021-05-25 Esperion Therapeutics Inc compostos de hidroxila, seu usos, e composições farmacêuticas
EP1701931B1 (en) 2003-12-24 2018-10-10 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20090018199A1 (en) * 2003-12-30 2009-01-15 Syndrome X Ltd. Methods of Administering 3, 3, 14, 14 Tetramethyl Hexadecane 1, 16 Dioic Acid
CN101365446B (zh) 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
JP5236664B2 (ja) 2007-02-01 2013-07-17 レスバーロジックス コーポレイション 心血管疾患を予防および治療するための化合物
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
ATE530178T1 (de) 2007-05-23 2011-11-15 Amcol International Corp Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger
AU2009262252B2 (en) 2008-06-26 2013-05-02 Resverlogix Corp. Methods of preparing quinazolinone derivatives
CA2747417C (en) 2009-01-08 2017-01-03 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ708314A (en) 2009-03-18 2017-08-25 Resverlogix Corp Quinazolinones for use as anticancer agents
BRPI1014956B8 (pt) 2009-04-22 2021-05-25 Resverlogix Corp agentes anti-inflamatórios
NZ710626A (en) 2009-09-03 2017-03-31 Pfizer Vaccines Llc Pcsk9 vaccine
CA2812109A1 (en) 2010-09-20 2012-03-29 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
US20140004142A1 (en) 2011-03-02 2014-01-02 Pfizer Inc. Pcsk9 vaccine
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US10479752B2 (en) * 2011-12-08 2019-11-19 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
KR102370582B1 (ko) 2015-03-13 2022-03-04 에스페리온 테라피유틱스 인코포레이티드 Ｅｔｃ1002 및 에제티미브를 포함하는 고정 용량 조합 및 제형 및 심혈관 질환의 치료 또는 이의 위험의 감소 방법
JP6903585B2 (ja) 2015-03-13 2021-07-14 レスバーロジックス コーポレイション 補体関連疾患の治療のための組成物および治療方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
EP3463330B1 (en) * 2016-06-02 2022-05-04 Syndromex Ltd. Diabetes treatment regimens using alpha, alpha-substituted long-chain amphipathic carboxylates
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
US20230141635A1 (en) 2019-06-21 2023-05-11 Esperion Therapeutics, Inc. Salt forms of bempedoic acid and methods for using the same

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GB1268082A (en) 1969-08-08 1972-03-22 Orsymonde Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
BE755550A (fr) * 1969-09-02 1971-02-01 Parke Davis & Co Acides alcanedioiques, leurs sels et leurs esters abaissant la teneur en triglycerides du serum sanguin
US3773946A (en) 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
FR2288516A2 (fr) 1974-10-21 1976-05-21 Orsymonde Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
IL64542A0 (en) 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
DE3423166A1 (de) 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4634975A (en) * 1984-09-17 1987-01-06 Progressive Dynamics, Inc. Method and apparatus for producing electromagnetic surveillance fields
JPS61171417A (ja) * 1985-01-23 1986-08-02 Wakunaga Seiyaku Kk 抗糖尿病剤
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3634356A1 (de) * 1986-10-08 1988-04-21 Epis Sa Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren
DE4224670A1 (de) * 1992-07-25 1994-01-27 Boehringer Mannheim Gmbh Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
JP2003001549A (ja) * 2001-06-26 2003-01-08 Howa Mach Ltd 光電式刃具折れ検知装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303653B1 (en) 1997-06-26 2001-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0988274A4 (en) 2000-10-18
JP5479857B2 (ja) 2014-04-23
EP0988274B1 (en) 2009-05-20
EP2112134B1 (en) 2013-10-30
CA2277075A1 (en) 1998-07-16
KR20070026888A (ko) 2007-03-08
US6284903B1 (en) 2001-09-04
EP2112134A1 (en) 2009-10-28
AU7994798A (en) 1998-08-03
KR20000069934A (ko) 2000-11-25
ATE431816T1 (de) 2009-06-15
CA2277075C (en) 2010-06-22
WO1998030530A1 (en) 1998-07-16
JP2001507713A (ja) 2001-06-12
EP0988274A1 (en) 2000-03-29
US20020049345A1 (en) 2002-04-25
IL119971A0 (en) 1997-04-15
JP2010077141A (ja) 2010-04-08
KR100806927B1 (ko) 2008-02-22
AU742945B2 (en) 2002-01-17
DE69739415D1 (de) 2009-07-02
US20040132818A1 (en) 2004-07-08
KR100806928B1 (ko) 2008-02-22
US6800772B2 (en) 2004-10-05

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Legal Events

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