IL118527A - Process for the preparation of D4T polymorphic form I of stavudine - Google Patents

Process for the preparation of D4T polymorphic form I of stavudine

Info

Publication number
IL118527A
IL118527A IL11852796A IL11852796A IL118527A IL 118527 A IL118527 A IL 118527A IL 11852796 A IL11852796 A IL 11852796A IL 11852796 A IL11852796 A IL 11852796A IL 118527 A IL118527 A IL 118527A
Authority
IL
Israel
Prior art keywords
polymorphic form
stavudine
preparation
polymorphic
approved
Prior art date
Application number
IL11852796A
Other languages
English (en)
Other versions
IL118527A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL118527A0 publication Critical patent/IL118527A0/xx
Publication of IL118527A publication Critical patent/IL118527A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL11852796A 1995-06-05 1996-06-02 Process for the preparation of D4T polymorphic form I of stavudine IL118527A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/465,208 US5608048A (en) 1995-06-05 1995-06-05 d4 T polymorphic Form 1 process

Publications (2)

Publication Number Publication Date
IL118527A0 IL118527A0 (en) 1996-10-16
IL118527A true IL118527A (en) 2000-07-16

Family

ID=23846880

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11852796A IL118527A (en) 1995-06-05 1996-06-02 Process for the preparation of D4T polymorphic form I of stavudine

Country Status (19)

Country Link
US (1) US5608048A (ja)
EP (1) EP0749969B1 (ja)
JP (1) JP4208976B2 (ja)
KR (1) KR100375957B1 (ja)
CN (1) CN1058723C (ja)
AT (1) ATE205203T1 (ja)
AU (1) AU694653B2 (ja)
CA (1) CA2176181C (ja)
DE (1) DE69614936T2 (ja)
DK (1) DK0749969T3 (ja)
ES (1) ES2160768T3 (ja)
GR (1) GR3036768T3 (ja)
HK (1) HK1003435A1 (ja)
HU (1) HU222285B1 (ja)
IL (1) IL118527A (ja)
MX (1) MX9601957A (ja)
PT (1) PT749969E (ja)
SG (1) SG43372A1 (ja)
TW (1) TW336937B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001285197A1 (en) * 2000-09-06 2002-03-22 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
US7825106B2 (en) * 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
US7737133B2 (en) * 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
WO2007099389A1 (en) * 2005-07-11 2007-09-07 Aurobindo Pharma Limited A new improved process for the preparation of stavudine form i
ITMI20060360A1 (it) * 2006-02-28 2007-09-01 Clariant Lsm Italia Spa Novel method for the preparation of stavudine polymorphic form 1 and form ii
JP5966186B2 (ja) * 2011-02-08 2016-08-10 国立大学法人高知大学 カルサイト単結晶の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4904770A (en) * 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US5672698A (en) * 1993-11-15 1997-09-30 Bristol-Myers Squibb Co. Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5539099A (en) * 1993-11-15 1996-07-23 Bristol-Myers Squibb Company Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine

Also Published As

Publication number Publication date
AU694653B2 (en) 1998-07-23
HU222285B1 (hu) 2003-05-28
EP0749969B1 (en) 2001-09-05
PT749969E (pt) 2001-12-28
JPH08333364A (ja) 1996-12-17
KR970001369A (ko) 1997-01-24
CA2176181A1 (en) 1996-12-06
HU9601517D0 (en) 1996-07-29
TW336937B (en) 1998-07-21
KR100375957B1 (ko) 2003-12-31
CA2176181C (en) 2007-03-13
DE69614936T2 (de) 2002-04-25
AU5469296A (en) 1996-12-19
US5608048A (en) 1997-03-04
CN1058723C (zh) 2000-11-22
CN1145903A (zh) 1997-03-26
DE69614936D1 (de) 2001-10-11
ES2160768T3 (es) 2001-11-16
ATE205203T1 (de) 2001-09-15
HUP9601517A3 (en) 2000-03-28
SG43372A1 (en) 1997-10-17
EP0749969A3 (en) 1997-03-19
IL118527A0 (en) 1996-10-16
MX9601957A (es) 1997-08-30
HK1003435A1 (en) 1998-10-30
EP0749969A2 (en) 1996-12-27
DK0749969T3 (da) 2001-11-26
HUP9601517A2 (en) 1997-05-28
GR3036768T3 (en) 2002-01-31
JP4208976B2 (ja) 2009-01-14

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees