TW336937B - Purification process for crystallizing d4T polymorphic form I - Google Patents

Purification process for crystallizing d4T polymorphic form I

Info

Publication number
TW336937B
TW336937B TW085105338A TW85105338A TW336937B TW 336937 B TW336937 B TW 336937B TW 085105338 A TW085105338 A TW 085105338A TW 85105338 A TW85105338 A TW 85105338A TW 336937 B TW336937 B TW 336937B
Authority
TW
Taiwan
Prior art keywords
polymorphic form
propanol
polymorphic
crystallizing
purification process
Prior art date
Application number
TW085105338A
Other languages
English (en)
Inventor
Rajesh Babulal Gandhi
Joseph Ballard Bogardus
Peter Michael Garofalo
Timothy Richard Mart
Robert Kevin Perrone
Murray Arthur Kaplan
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of TW336937B publication Critical patent/TW336937B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
TW085105338A 1995-06-05 1996-05-03 Purification process for crystallizing d4T polymorphic form I TW336937B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/465,208 US5608048A (en) 1995-06-05 1995-06-05 d4 T polymorphic Form 1 process

Publications (1)

Publication Number Publication Date
TW336937B true TW336937B (en) 1998-07-21

Family

ID=23846880

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085105338A TW336937B (en) 1995-06-05 1996-05-03 Purification process for crystallizing d4T polymorphic form I

Country Status (19)

Country Link
US (1) US5608048A (zh)
EP (1) EP0749969B1 (zh)
JP (1) JP4208976B2 (zh)
KR (1) KR100375957B1 (zh)
CN (1) CN1058723C (zh)
AT (1) ATE205203T1 (zh)
AU (1) AU694653B2 (zh)
CA (1) CA2176181C (zh)
DE (1) DE69614936T2 (zh)
DK (1) DK0749969T3 (zh)
ES (1) ES2160768T3 (zh)
GR (1) GR3036768T3 (zh)
HK (1) HK1003435A1 (zh)
HU (1) HU222285B1 (zh)
IL (1) IL118527A (zh)
MX (1) MX9601957A (zh)
PT (1) PT749969E (zh)
SG (1) SG43372A1 (zh)
TW (1) TW336937B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020538A2 (en) * 2000-09-06 2002-03-14 Bristol-Myers Squibb Company Stavudine polymorphic form 1 process
US7825106B2 (en) * 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
US7737133B2 (en) * 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
WO2007099389A1 (en) * 2005-07-11 2007-09-07 Aurobindo Pharma Limited A new improved process for the preparation of stavudine form i
ITMI20060360A1 (it) * 2006-02-28 2007-09-01 Clariant Lsm Italia Spa Novel method for the preparation of stavudine polymorphic form 1 and form ii
JP5966186B2 (ja) * 2011-02-08 2016-08-10 国立大学法人高知大学 カルサイト単結晶の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4904770A (en) * 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US5539099A (en) * 1993-11-15 1996-07-23 Bristol-Myers Squibb Company Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
US5672698A (en) * 1993-11-15 1997-09-30 Bristol-Myers Squibb Co. Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine

Also Published As

Publication number Publication date
EP0749969B1 (en) 2001-09-05
ES2160768T3 (es) 2001-11-16
PT749969E (pt) 2001-12-28
HK1003435A1 (en) 1998-10-30
EP0749969A3 (en) 1997-03-19
CA2176181C (en) 2007-03-13
GR3036768T3 (en) 2002-01-31
AU694653B2 (en) 1998-07-23
AU5469296A (en) 1996-12-19
DK0749969T3 (da) 2001-11-26
HU222285B1 (hu) 2003-05-28
DE69614936T2 (de) 2002-04-25
EP0749969A2 (en) 1996-12-27
ATE205203T1 (de) 2001-09-15
MX9601957A (es) 1997-08-30
JP4208976B2 (ja) 2009-01-14
IL118527A0 (en) 1996-10-16
HUP9601517A3 (en) 2000-03-28
US5608048A (en) 1997-03-04
SG43372A1 (en) 1997-10-17
HUP9601517A2 (en) 1997-05-28
HU9601517D0 (en) 1996-07-29
IL118527A (en) 2000-07-16
JPH08333364A (ja) 1996-12-17
KR970001369A (ko) 1997-01-24
CA2176181A1 (en) 1996-12-06
CN1058723C (zh) 2000-11-22
CN1145903A (zh) 1997-03-26
DE69614936D1 (de) 2001-10-11
KR100375957B1 (ko) 2003-12-31

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees