IL117170A - Nonatetraenoic acid derivatives and pharmaceutical compositions containing them - Google Patents

Nonatetraenoic acid derivatives and pharmaceutical compositions containing them

Info

Publication number
IL117170A
IL117170A IL11717096A IL11717096A IL117170A IL 117170 A IL117170 A IL 117170A IL 11717096 A IL11717096 A IL 11717096A IL 11717096 A IL11717096 A IL 11717096A IL 117170 A IL117170 A IL 117170A
Authority
IL
Israel
Prior art keywords
acid derivatives
pharmaceutical compositions
compositions containing
nonatetraenoic acid
nonatetraenoic
Prior art date
Application number
IL11717096A
Other languages
English (en)
Other versions
IL117170A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL117170A0 publication Critical patent/IL117170A0/xx
Publication of IL117170A publication Critical patent/IL117170A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Vapour Deposition (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cosmetics (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
IL11717096A 1995-02-24 1996-02-19 Nonatetraenoic acid derivatives and pharmaceutical compositions containing them IL117170A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39398095A 1995-02-24 1995-02-24
US46828995A 1995-06-06 1995-06-06

Publications (2)

Publication Number Publication Date
IL117170A0 IL117170A0 (en) 1996-06-18
IL117170A true IL117170A (en) 2000-11-21

Family

ID=27014530

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11717096A IL117170A (en) 1995-02-24 1996-02-19 Nonatetraenoic acid derivatives and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US5986131A (ja)
EP (1) EP0728742B1 (ja)
JP (1) JP2776787B2 (ja)
KR (1) KR100414342B1 (ja)
CN (1) CN1124260C (ja)
AT (1) ATE185799T1 (ja)
AU (1) AU703115B2 (ja)
CA (1) CA2170227A1 (ja)
CZ (1) CZ291352B6 (ja)
DE (1) DE69604713T2 (ja)
DK (1) DK0728742T3 (ja)
ES (1) ES2138765T3 (ja)
FI (1) FI960856A (ja)
GR (1) GR3032407T3 (ja)
HK (1) HK1012330A1 (ja)
HU (1) HU219538B (ja)
IL (1) IL117170A (ja)
MA (1) MA23813A1 (ja)
MY (1) MY113430A (ja)
NO (1) NO309189B1 (ja)
NZ (1) NZ286017A (ja)
RU (1) RU2166499C2 (ja)
SG (1) SG59945A1 (ja)
TW (1) TW343966B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2270537T3 (es) 1997-11-12 2007-04-01 F. Hoffmann-La Roche Ag Tratamiento de enfermedades inmunes mediadas por celulas t ayudantes de tipo 2.
US6326397B1 (en) 1998-11-10 2001-12-04 Hoffman-La Roche Inc. Retinoid antagonists and use thereof
JP4543513B2 (ja) * 2000-07-17 2010-09-15 ソニー株式会社 双方向通信システム、表示装置、ベース装置および双方向通信方法
EP1935869A1 (en) 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
US7314953B2 (en) 2001-03-27 2008-01-01 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
EP1511477A4 (en) 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
EP1621191A1 (en) * 2004-07-29 2006-02-01 Werner Bollag Treatment of inflammatory diseases by RXR Antagonists
JP2008508209A (ja) * 2004-07-29 2008-03-21 ボラーク ヴェルナー 多発性硬化症に対するｒｘｒアンタゴニスト治療
EP1940378A1 (en) * 2005-10-25 2008-07-09 Werner Bollag Rxr agonists and antagonists, alone or in combination with ppar ligands, in the treatment of metabolic and cardiovascular diseases
CN105646311B (zh) * 2016-03-31 2017-09-26 广州巨元生化有限公司 一种制备β‑阿朴‑8’‑胡萝卜醛的方法
EP3301085A1 (en) * 2016-09-29 2018-04-04 Biogem S.Ca.R.L. Retinoid derivatives with antitumor activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277147A (en) * 1963-06-05 1966-10-04 Olin Mathieson Lower alkyl esters of beta-cyclocitrylidene fluoroacetic acid and beta-ionylidene fluoroacetic acid
US5514672A (en) * 1981-02-17 1996-05-07 Bazzano; Gail S. Use of retinoids and compositions containing same for hair growth
CA2153236A1 (en) * 1993-01-11 1995-02-09 Marcus F. Boehm Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors
IL116259A (en) * 1994-12-19 2000-07-16 American Cyanamid Co Analogs of 9-cis retinoic acid and their use

Also Published As

Publication number Publication date
FI960856A0 (fi) 1996-02-23
CZ53796A3 (en) 1996-11-13
HUP9600424A3 (en) 1998-04-28
NO960751D0 (no) 1996-02-23
DK0728742T3 (da) 2000-04-17
KR960031422A (ko) 1996-09-17
IL117170A0 (en) 1996-06-18
CZ291352B6 (cs) 2003-02-12
RU2166499C2 (ru) 2001-05-10
HK1012330A1 (en) 1999-07-30
ES2138765T3 (es) 2000-01-16
TW343966B (en) 1998-11-01
MY113430A (en) 2002-02-28
CN1124260C (zh) 2003-10-15
EP0728742A2 (en) 1996-08-28
EP0728742B1 (en) 1999-10-20
MA23813A1 (fr) 1996-10-01
GR3032407T3 (en) 2000-05-31
DE69604713T2 (de) 2000-06-21
EP0728742A3 (en) 1996-10-23
ATE185799T1 (de) 1999-11-15
NO309189B1 (no) 2000-12-27
US5986131A (en) 1999-11-16
HUP9600424A2 (en) 1996-12-30
JP2776787B2 (ja) 1998-07-16
KR100414342B1 (ko) 2004-05-10
AU4561796A (en) 1996-09-05
NO960751L (no) 1996-08-26
JPH08259527A (ja) 1996-10-08
HU219538B (hu) 2001-05-28
AU703115B2 (en) 1999-03-18
SG59945A1 (en) 1999-02-22
NZ286017A (en) 1997-12-19
HU9600424D0 (en) 1996-04-29
CN1136557A (zh) 1996-11-27
CA2170227A1 (en) 1996-08-25
DE69604713D1 (de) 1999-11-25
FI960856A (fi) 1996-08-25

Similar Documents

Publication Publication Date Title
IL117170A (en) Nonatetraenoic acid derivatives and pharmaceutical compositions containing them
AU3382195A (en) Retinoic acid x-receptor ligands
AU6225894A (en) Compounds having selectivity for retinoid x receptors
DE68917512D1 (de) Kosmetisches Präparat.
GR3034841T3 (en) Compounds having selectivity for retinoid x receptors.
AU5664294A (en) Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors
AU4545493A (en) Synthesis of zeolite films bonded to substrates, structures and uses thereof
ES2148593T3 (es) Compuestos retinoides trienoicos novedosos y metodos.
CA2320388A1 (en) Novel dihydroxyhexanoic acid derivatives
GR3029956T3 (en) Synthesis of amido acids from carboxylic acids and lactams
AU4306197A (en) Use of inhibitors of the activity of retinoic acid to promote healing
JO1930B1 (en) Bioactive preparations
AU8302787A (en) Use of 13-cis retinoic acid
GB2232416B (en) Cyanohydrin derivatives and their use in liquid crystal materials and devices
AU3001100A (en) Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars
TH33708A (th) เอสเทอร์และสารผสมต่าง ๆ ทางเภสัชกรรม
IE792520L (en) 1ó-hydroxycalcioic acid and esters.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees