IL116849A - Process for the preparation of aspartic acid - Google Patents
Process for the preparation of aspartic acidInfo
- Publication number
- IL116849A IL116849A IL11684996A IL11684996A IL116849A IL 116849 A IL116849 A IL 116849A IL 11684996 A IL11684996 A IL 11684996A IL 11684996 A IL11684996 A IL 11684996A IL 116849 A IL116849 A IL 116849A
- Authority
- IL
- Israel
- Prior art keywords
- fumarate
- calcium
- ammonium
- pct
- preparation
- Prior art date
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 6
- 235000019297 ammonium fumarate Nutrition 0.000 abstract 5
- CKKXWJDFFQPBQL-SEPHDYHBSA-N azane;(e)-but-2-enedioic acid Chemical compound N.N.OC(=O)\C=C\C(O)=O CKKXWJDFFQPBQL-SEPHDYHBSA-N 0.000 abstract 5
- 239000001729 Ammonium fumarate Substances 0.000 abstract 4
- RWYRUDPAALLKPX-UHFFFAOYSA-N 2,2-difluoro-n-methylethanamine;hydrochloride Chemical compound Cl.CNCC(F)F RWYRUDPAALLKPX-UHFFFAOYSA-N 0.000 abstract 3
- 239000001749 Calcium fumarate Substances 0.000 abstract 3
- 229910021529 ammonia Inorganic materials 0.000 abstract 3
- 235000019296 calcium fumarate Nutrition 0.000 abstract 3
- 238000000855 fermentation Methods 0.000 abstract 3
- 230000004151 fermentation Effects 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 2
- 235000003704 aspartic acid Nutrition 0.000 abstract 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 abstract 1
- 239000001099 ammonium carbonate Substances 0.000 abstract 1
- 235000012501 ammonium carbonate Nutrition 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- YEOCBTKAGVNPMO-JIZZDEOASA-N diazanium;(2s)-2-aminobutanedioate Chemical compound [NH4+].[NH4+].[O-]C(=O)[C@@H](N)CC([O-])=O YEOCBTKAGVNPMO-JIZZDEOASA-N 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/20—Aspartic acid; Asparagine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11684996A IL116849A (en) | 1996-01-22 | 1996-01-22 | Process for the preparation of aspartic acid |
| DE69715151T DE69715151T2 (de) | 1996-01-22 | 1997-01-21 | Verfahren zur herstellung von asparaginsäure |
| US09/101,779 US5972662A (en) | 1996-01-22 | 1997-01-21 | Process for the preparation of aspartic acid |
| EP97901152A EP0876499B1 (de) | 1996-01-22 | 1997-01-21 | Verfahren zur herstellung von asparaginsäure |
| AU14497/97A AU1449797A (en) | 1996-01-22 | 1997-01-21 | Process for the preparation of aspartic acid |
| ES97901152T ES2182020T3 (es) | 1996-01-22 | 1997-01-21 | Proceso de produccion de acido aspartico. |
| AT97901152T ATE223494T1 (de) | 1996-01-22 | 1997-01-21 | Verfahren zur herstellung von asparaginsäure |
| PCT/GB1997/000176 WO1997027312A1 (en) | 1996-01-22 | 1997-01-21 | Process for the preparation of aspartic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11684996A IL116849A (en) | 1996-01-22 | 1996-01-22 | Process for the preparation of aspartic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL116849A0 IL116849A0 (en) | 1996-07-23 |
| IL116849A true IL116849A (en) | 1999-12-31 |
Family
ID=11068464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11684996A IL116849A (en) | 1996-01-22 | 1996-01-22 | Process for the preparation of aspartic acid |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5972662A (de) |
| EP (1) | EP0876499B1 (de) |
| AT (1) | ATE223494T1 (de) |
| AU (1) | AU1449797A (de) |
| DE (1) | DE69715151T2 (de) |
| ES (1) | ES2182020T3 (de) |
| IL (1) | IL116849A (de) |
| WO (1) | WO1997027312A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071728A (en) * | 1997-01-09 | 2000-06-06 | Amylum Belgium, N.V. | Process for the production of crystalline aspartic acid |
| IL119986A (en) * | 1997-01-09 | 2000-10-31 | Amylum Nv | Process for the production of crystalline aspartic acid |
| RU2174558C1 (ru) * | 2000-12-07 | 2001-10-10 | Закрытое акционерное общество "Биоамид" | Способ получения l-аспарагиновой кислоты |
| US20060035310A1 (en) * | 2004-08-13 | 2006-02-16 | Millipore Corporation | Media for recovery of microorganism in the presence of antibiotics |
| CN107475320A (zh) * | 2017-08-23 | 2017-12-15 | 安徽雪郎生物科技股份有限公司 | L‑天门冬氨酸的绿色生产方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB146411A (en) * | 1915-09-28 | 1921-10-03 | Carl Wehmer | Improved manufacture of fumaric acid |
| US2327191A (en) * | 1939-12-07 | 1943-08-17 | Pfizer & Co C | Production of fumaric acid |
| US3030276A (en) * | 1960-02-09 | 1962-04-17 | Alfred M Thomsen | Method of making fumaric acid and urea from lignified cellulose |
| GB1004218A (en) * | 1962-05-26 | 1965-09-15 | Ajinomoto Kk | A process for producing l-aspartic acid |
| IT1023343B (it) * | 1974-11-21 | 1978-05-10 | Liquichimica Spa | Metodo di produzione di acido l aspartico per fermentazione di idrocarburi |
| JPS57138383A (en) * | 1981-02-20 | 1982-08-26 | Tanabe Seiyaku Co Ltd | Preparation of l-aspartic acid |
| US4877731A (en) * | 1988-06-27 | 1989-10-31 | E. I. Du Pont De Nemours And Company | Fermentation process for carboxylic acids |
| US5352825A (en) * | 1993-07-06 | 1994-10-04 | Hoarmann & Reimer Corp. | Recovery of organic acid salts from impure process streams by addition of bases |
-
1996
- 1996-01-22 IL IL11684996A patent/IL116849A/xx not_active IP Right Cessation
-
1997
- 1997-01-21 AU AU14497/97A patent/AU1449797A/en not_active Abandoned
- 1997-01-21 ES ES97901152T patent/ES2182020T3/es not_active Expired - Lifetime
- 1997-01-21 AT AT97901152T patent/ATE223494T1/de not_active IP Right Cessation
- 1997-01-21 US US09/101,779 patent/US5972662A/en not_active Expired - Lifetime
- 1997-01-21 WO PCT/GB1997/000176 patent/WO1997027312A1/en not_active Ceased
- 1997-01-21 DE DE69715151T patent/DE69715151T2/de not_active Expired - Fee Related
- 1997-01-21 EP EP97901152A patent/EP0876499B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69715151D1 (de) | 2002-10-10 |
| DE69715151T2 (de) | 2003-02-27 |
| EP0876499B1 (de) | 2002-09-04 |
| WO1997027312A1 (en) | 1997-07-31 |
| ES2182020T3 (es) | 2003-03-01 |
| EP0876499A1 (de) | 1998-11-11 |
| ATE223494T1 (de) | 2002-09-15 |
| US5972662A (en) | 1999-10-26 |
| AU1449797A (en) | 1997-08-20 |
| IL116849A0 (en) | 1996-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |