IL113918A - Process for preparing delta 9, 11 corticosteroids - Google Patents

Process for preparing delta 9, 11 corticosteroids

Info

Publication number
IL113918A
IL113918A IL11391895A IL11391895A IL113918A IL 113918 A IL113918 A IL 113918A IL 11391895 A IL11391895 A IL 11391895A IL 11391895 A IL11391895 A IL 11391895A IL 113918 A IL113918 A IL 113918A
Authority
IL
Israel
Prior art keywords
steroids
delta
chloro
corticosteroids
beta
Prior art date
Application number
IL11391895A
Other languages
English (en)
Other versions
IL113918A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to IL12659895A priority Critical patent/IL126598A/xx
Priority to IL12659795A priority patent/IL126597A/xx
Publication of IL113918A0 publication Critical patent/IL113918A0/xx
Priority to IL12659798A priority patent/IL126597A0/xx
Priority to IL12659898A priority patent/IL126598A0/xx
Publication of IL113918A publication Critical patent/IL113918A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
IL11391895A 1994-06-01 1995-05-30 Process for preparing delta 9, 11 corticosteroids IL113918A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL12659895A IL126598A (en) 1994-06-01 1995-05-30 Process for preparing 21-chloro corticosteroids
IL12659795A IL126597A (en) 1994-06-01 1995-05-30 PROCESS FOR PREPARING Delta 9, 11 CORTICOSTEROIDS
IL12659798A IL126597A0 (en) 1994-06-01 1998-10-15 Process for preparing delta 9,11 corticosteroids
IL12659898A IL126598A0 (en) 1994-06-01 1998-10-15 Process for preparing 21-chloro corticosteroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/252,302 US5502222A (en) 1994-06-01 1994-06-01 Process for preparing delta 9,11 and 21-chloro corticosteroids

Publications (2)

Publication Number Publication Date
IL113918A0 IL113918A0 (en) 1995-08-31
IL113918A true IL113918A (en) 1999-12-31

Family

ID=22955451

Family Applications (5)

Application Number Title Priority Date Filing Date
IL11391895A IL113918A (en) 1994-06-01 1995-05-30 Process for preparing delta 9, 11 corticosteroids
IL12659795A IL126597A (en) 1994-06-01 1995-05-30 PROCESS FOR PREPARING Delta 9, 11 CORTICOSTEROIDS
IL12659895A IL126598A (en) 1994-06-01 1995-05-30 Process for preparing 21-chloro corticosteroids
IL12659798A IL126597A0 (en) 1994-06-01 1998-10-15 Process for preparing delta 9,11 corticosteroids
IL12659898A IL126598A0 (en) 1994-06-01 1998-10-15 Process for preparing 21-chloro corticosteroids

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL12659795A IL126597A (en) 1994-06-01 1995-05-30 PROCESS FOR PREPARING Delta 9, 11 CORTICOSTEROIDS
IL12659895A IL126598A (en) 1994-06-01 1995-05-30 Process for preparing 21-chloro corticosteroids
IL12659798A IL126597A0 (en) 1994-06-01 1998-10-15 Process for preparing delta 9,11 corticosteroids
IL12659898A IL126598A0 (en) 1994-06-01 1998-10-15 Process for preparing 21-chloro corticosteroids

Country Status (18)

Country Link
US (3) US5502222A (fr)
EP (3) EP0763054B1 (fr)
JP (1) JP2831472B2 (fr)
KR (4) KR100226568B1 (fr)
AT (3) ATE395353T1 (fr)
AU (1) AU696425B2 (fr)
CA (1) CA2191324C (fr)
DE (3) DE69514352T2 (fr)
DK (1) DK0063054T3 (fr)
ES (3) ES2306487T3 (fr)
FI (3) FI118801B (fr)
GR (1) GR3032714T3 (fr)
HU (3) HU227379B1 (fr)
IL (5) IL113918A (fr)
MX (1) MX9605893A (fr)
NZ (1) NZ287348A (fr)
PT (1) PT763054E (fr)
WO (1) WO1995032989A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
WO1997021720A2 (fr) * 1995-12-11 1997-06-19 G.D. Searle And Co. Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles
CN100369927C (zh) 1996-12-11 2008-02-20 G·D·瑟尔公司 9,11-环氧甾族化合物和其中有用的中间体的制备方法
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
JP2005523306A (ja) * 2002-03-22 2005-08-04 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー エプレレノンの製法
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
EP2064191B1 (fr) 2006-12-12 2014-06-25 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase d'aspartyle
HUE046243T2 (hu) 2008-05-28 2020-02-28 Reveragen Biopharma Inc Nem-hormonális NF-KB szteroid modulátorok betegség kezelésére
EP2556083A4 (fr) 2010-04-05 2013-12-04 Validus Biopharma Inc Modulateurs stéroïdes non hormonaux de nf- kappa b pour le traitement de maladies
CN102225959B (zh) * 2011-04-29 2012-11-07 中国科学院上海有机化学研究所 一种16β-甲基-17α-羟基孕甾-3,20-二酮化合物及其合成方法
WO2017004205A1 (fr) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. Modulateurs stéroïdiens non hormonaux de nf-κb pour le traitement de maladies
CN107840865A (zh) * 2016-09-20 2018-03-27 天津金耀集团有限公司 一种甲泼尼龙的制备方法
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US11326998B2 (en) 2019-04-19 2022-05-10 Kidde Technologies, Inc. System and method for monitoring a fire suppression blend
US10953257B2 (en) 2019-04-19 2021-03-23 Kidde Technologies, Inc. Fire suppression composition
EP4134373A1 (fr) 2021-08-12 2023-02-15 Santhera Pharmaceuticals (Schweiz) AG Synthèse de stéroïdes delta 9,11

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28369E (en) * 1957-02-27 1975-03-18 Atcc-zxs
US3947409A (en) * 1958-06-19 1976-03-30 Merck & Co., Inc. 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof
DE1127895B (de) * 1958-12-24 1962-04-19 Ciba Geigy Verfahren zur Herstellung von reinen 9 (11)-ungesaettigten Steroiden
US3284477A (en) * 1963-07-10 1966-11-08 Schering Corp Diuretic 1, 4, 9(11)-pregnatrienes
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
US3933799A (en) * 1969-01-29 1976-01-20 Glaxo Laboratories Limited 11β-Halo-9,12-unsubstituted-C19 -steroids
GB1504133A (en) * 1975-02-24 1978-03-15 Palladino G 2-bromo-6beta-fluoro-pregnane compounds
GB1504134A (en) * 1975-02-25 1978-03-15 Palladino G 2-bromo-6beta-fluoro-pregnane compounds
BG33738A3 (en) * 1978-01-25 1983-04-15 Schering Ag,De Method for obtaining of substituated in 17- th position steroids from pregnan row
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3640709A1 (de) * 1986-11-28 1988-06-09 Schering Ag Verfahren zur herstellung von 6(alpha),9(alpha)-difluor-11ss,17(alpha)-dihydroxy-16(alpha)-methyl-4-pregnen-3,20-dion und dessen derivate
US4920216A (en) * 1987-05-28 1990-04-24 The Trustees Of Columbia In The City Of New York Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids

Also Published As

Publication number Publication date
EP0969011A3 (fr) 2004-10-06
DE69514352T2 (de) 2000-08-24
US5616742A (en) 1997-04-01
CA2191324C (fr) 2001-08-28
FI964739A0 (fi) 1996-11-28
EP0763054B1 (fr) 2000-01-05
AU696425B2 (en) 1998-09-10
ATE188481T1 (de) 2000-01-15
IL126597A0 (en) 1999-08-17
EP0969011B1 (fr) 2008-05-28
KR100290225B1 (ko) 2001-05-15
ATE397008T1 (de) 2008-06-15
HU9603299D0 (en) 1997-01-28
ES2306487T3 (es) 2008-11-01
EP0969012B1 (fr) 2008-05-14
IL126598A (en) 2003-07-31
EP0763054A1 (fr) 1997-03-19
HU0302654D0 (en) 2003-10-28
FI118801B (fi) 2008-03-31
CA2191324A1 (fr) 1995-12-07
US5750745A (en) 1998-05-12
KR100290227B1 (ko) 2001-05-15
KR100226568B1 (ko) 1999-10-15
IL126597A (en) 2003-09-17
HU227378B1 (en) 2011-05-30
AU2603595A (en) 1995-12-21
NZ287348A (en) 1998-12-23
EP0969011A2 (fr) 2000-01-05
DK0063054T3 (da) 2000-06-19
HU1000527D0 (en) 2010-11-29
IL126598A0 (en) 1999-08-17
WO1995032989A1 (fr) 1995-12-07
HUT75518A (en) 1997-05-28
ES2140678T3 (es) 2000-03-01
HU227379B1 (en) 2011-05-30
EP0969012A3 (fr) 2004-10-06
ATE395353T1 (de) 2008-05-15
DE69535756D1 (de) 2008-06-26
FI117600B (fi) 2006-12-15
GR3032714T3 (en) 2000-06-30
FI964739A (fi) 1996-11-28
ES2306488T3 (es) 2008-11-01
US5502222A (en) 1996-03-26
PT763054E (pt) 2000-06-30
FI20050181A (fi) 2005-02-16
KR100290226B1 (ko) 2001-05-15
JPH09506113A (ja) 1997-06-17
FI20050180A (fi) 2005-02-16
MX9605893A (es) 1997-12-31
DE69514352D1 (de) 2000-02-10
HU227380B1 (en) 2011-05-30
IL113918A0 (en) 1995-08-31
FI117599B (fi) 2006-12-15
DE69535765D1 (de) 2008-07-10
JP2831472B2 (ja) 1998-12-02
EP0969012A2 (fr) 2000-01-05

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees