IL110563A - Kynurenine aminotransferase inhibitors a process for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
Kynurenine aminotransferase inhibitors a process for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL110563A IL110563A IL11056394A IL11056394A IL110563A IL 110563 A IL110563 A IL 110563A IL 11056394 A IL11056394 A IL 11056394A IL 11056394 A IL11056394 A IL 11056394A IL 110563 A IL110563 A IL 110563A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- halogen
- inhibitors
- Prior art date
Links
- 108010068073 Kynurenine-oxoglutarate transaminase Proteins 0.000 title abstract 4
- 239000002380 aminotransferase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 phenyl-C1-C4 alkyl Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 208000014644 Brain disease Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 125000000033 alkoxyamino group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 230000009984 peri-natal effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/102,843 US5519055A (en) | 1993-08-06 | 1993-08-06 | Substituted kynurenines and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110563A0 IL110563A0 (en) | 1994-11-11 |
| IL110563A true IL110563A (en) | 1999-04-11 |
Family
ID=22291962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11056394A IL110563A (en) | 1993-08-06 | 1994-08-04 | Kynurenine aminotransferase inhibitors a process for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5519055A (fr) |
| EP (2) | EP0919538A1 (fr) |
| JP (1) | JPH08502523A (fr) |
| CN (1) | CN1113386A (fr) |
| AT (1) | ATE181728T1 (fr) |
| AU (1) | AU680672B2 (fr) |
| CA (1) | CA2145178A1 (fr) |
| DE (1) | DE69419306D1 (fr) |
| FI (1) | FI951631A0 (fr) |
| HU (1) | HUT70394A (fr) |
| IL (1) | IL110563A (fr) |
| PL (1) | PL308237A1 (fr) |
| TW (1) | TW408099B (fr) |
| WO (1) | WO1995004714A1 (fr) |
| ZA (1) | ZA945830B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9521486D0 (en) * | 1995-10-20 | 1995-12-20 | Pharmacia Spa | Fluoro-substituted benzoylpropionic acid derivatives |
| GB9522617D0 (en) * | 1995-11-03 | 1996-01-03 | Pharmacia Spa | 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity |
| GB9522615D0 (en) | 1995-11-03 | 1996-01-03 | Pharmacia Spa | 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity |
| GB9618349D0 (en) * | 1996-09-03 | 1996-10-16 | Pharmacia Spa | N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
| GB9725055D0 (en) * | 1997-11-26 | 1998-01-28 | Pharmacia & Upjohn Spa | 1,3,4-thiadiazoles compounds |
| CN1330774C (zh) * | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | 犬尿氨酸水解酶多态性及其用途 |
| ITMI20041626A1 (it) * | 2004-08-06 | 2004-11-06 | Roberto Pellicciari | Inibitori della chinurenina-ammino-trasferasi |
| AU2006320567A1 (en) * | 2005-11-30 | 2007-06-07 | The University Of Maryland, Baltimore | Inhibitors of kynurenine aminotransferase and uses therefor |
| AU2011336214B2 (en) * | 2010-12-01 | 2015-08-20 | Pfizer Inc. | KAT II inhibitors |
| JP6340409B2 (ja) | 2013-03-14 | 2018-06-06 | ヴィスタゲン セラピューティクス、インコーポレイテッド | キラルキヌレニン化合物の合成方法 |
| BR112016024455B1 (pt) * | 2014-04-23 | 2023-02-07 | Mitsubishi Tanabe Pharma Corporation | Composto heterocíclico bicíclico ou tricíclico |
| JP6853782B2 (ja) | 2015-10-22 | 2021-03-31 | 田辺三菱製薬株式会社 | 新規二環性複素環化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU643365B2 (en) * | 1991-02-28 | 1993-11-11 | Aventisub Ii Inc. | NMDA antagonists |
| CA2108670A1 (fr) * | 1991-04-18 | 1992-10-19 | Robert S. Phillips | Inhibiteurs de la kynureninase |
| US5495044A (en) * | 1991-04-18 | 1996-02-27 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
| IT1265101B1 (it) * | 1993-07-23 | 1996-10-30 | Erba Carlo Spa | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
-
1993
- 1993-08-06 US US08/102,843 patent/US5519055A/en not_active Expired - Fee Related
-
1994
- 1994-07-15 EP EP98122053A patent/EP0919538A1/fr not_active Withdrawn
- 1994-07-15 AT AT94922532T patent/ATE181728T1/de not_active IP Right Cessation
- 1994-07-15 CA CA002145178A patent/CA2145178A1/fr not_active Abandoned
- 1994-07-15 HU HU9500997A patent/HUT70394A/hu unknown
- 1994-07-15 EP EP94922532A patent/EP0663899B1/fr not_active Expired - Lifetime
- 1994-07-15 AU AU73602/94A patent/AU680672B2/en not_active Ceased
- 1994-07-15 WO PCT/US1994/007804 patent/WO1995004714A1/fr active IP Right Grant
- 1994-07-15 PL PL94308237A patent/PL308237A1/xx unknown
- 1994-07-15 CN CN94190583A patent/CN1113386A/zh active Pending
- 1994-07-15 DE DE69419306T patent/DE69419306D1/de not_active Expired - Lifetime
- 1994-07-15 JP JP7506414A patent/JPH08502523A/ja active Pending
- 1994-07-20 TW TW083106650A patent/TW408099B/zh active
- 1994-08-04 ZA ZA945830A patent/ZA945830B/xx unknown
- 1994-08-04 IL IL11056394A patent/IL110563A/xx not_active IP Right Cessation
-
1995
- 1995-04-05 FI FI951631A patent/FI951631A0/fi unknown
- 1995-06-05 US US08/463,895 patent/US5708030A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI951631A (fi) | 1995-04-05 |
| CA2145178A1 (fr) | 1995-02-16 |
| EP0663899A1 (fr) | 1995-07-26 |
| EP0919538A1 (fr) | 1999-06-02 |
| IL110563A0 (en) | 1994-11-11 |
| HU9500997D0 (en) | 1995-06-28 |
| FI951631A0 (fi) | 1995-04-05 |
| ATE181728T1 (de) | 1999-07-15 |
| HUT70394A (en) | 1995-10-30 |
| JPH08502523A (ja) | 1996-03-19 |
| EP0663899A4 (fr) | 1996-01-17 |
| AU680672B2 (en) | 1997-08-07 |
| AU7360294A (en) | 1995-02-28 |
| WO1995004714A1 (fr) | 1995-02-16 |
| US5708030A (en) | 1998-01-13 |
| CN1113386A (zh) | 1995-12-13 |
| TW408099B (en) | 2000-10-11 |
| ZA945830B (en) | 1995-03-09 |
| PL308237A1 (en) | 1995-07-24 |
| DE69419306D1 (de) | 1999-08-05 |
| EP0663899B1 (fr) | 1999-06-30 |
| US5519055A (en) | 1996-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| RH | Patent void |