IL110255A - Formation and resolution of 2-tert-butylcarboxamido-piperazine - Google Patents
Formation and resolution of 2-tert-butylcarboxamido-piperazineInfo
- Publication number
- IL110255A IL110255A IL11025594A IL11025594A IL110255A IL 110255 A IL110255 A IL 110255A IL 11025594 A IL11025594 A IL 11025594A IL 11025594 A IL11025594 A IL 11025594A IL 110255 A IL110255 A IL 110255A
- Authority
- IL
- Israel
- Prior art keywords
- acid
- tert
- mixture
- piperazine
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9262793A | 1993-07-16 | 1993-07-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110255A0 IL110255A0 (en) | 1994-10-21 |
| IL110255A true IL110255A (en) | 1998-12-06 |
Family
ID=22234214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11025594A IL110255A (en) | 1993-07-16 | 1994-07-08 | Formation and resolution of 2-tert-butylcarboxamido-piperazine |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US5693803A (ro) |
| EP (2) | EP0708763B1 (ro) |
| JP (1) | JPH09500131A (ro) |
| KR (2) | KR100325279B1 (ro) |
| CN (1) | CN1046715C (ro) |
| AT (1) | ATE233249T1 (ro) |
| AU (1) | AU679770B2 (ro) |
| CA (1) | CA2167408C (ro) |
| CZ (1) | CZ13096A3 (ro) |
| DE (1) | DE69432176T2 (ro) |
| ES (1) | ES2191683T3 (ro) |
| FI (1) | FI960206L (ro) |
| HU (1) | HUT76789A (ro) |
| IL (1) | IL110255A (ro) |
| NZ (1) | NZ269400A (ro) |
| RO (3) | RO117019B1 (ro) |
| RU (1) | RU2134263C1 (ro) |
| UA (1) | UA45317C2 (ro) |
| WO (1) | WO1995002583A1 (ro) |
| ZA (1) | ZA945194B (ro) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69300043T2 (de) * | 1992-03-13 | 1995-05-24 | Bio Mega Boehringer Ingelheim | Substituierte Pipecoline-Säurederivate als HIV-Protease-Hemmer. |
| CN1046272C (zh) * | 1993-11-22 | 1999-11-10 | 广荣化学工业株式会社 | N-叔丁基-2-吡嗪羧基酰胺类的制造方法 |
| DK0710652T3 (da) * | 1994-11-04 | 1998-09-28 | Yamakawa Chemical Ind | Fremgangsmåde til fremstilling af optisk aktive piperazinderivater og mellemprodukter til fremstillingen |
| EP1125930A1 (de) * | 1995-05-23 | 2001-08-22 | Lonza Ag | Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung |
| PT744401E (pt) * | 1995-05-23 | 2002-05-31 | Lonza Ag | Processo para a producao de derivados de acido 2-piperazinocarboxilico opticamente activos |
| CA2201218C (en) * | 1996-04-23 | 2004-09-28 | Rudolf Fuchs | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives |
| US5981759A (en) * | 1997-06-20 | 1999-11-09 | Merck & Co., Inc. | Process for indinavir intermediate |
| GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
| JP2003514910A (ja) | 1999-11-24 | 2003-04-22 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖプロテアーゼ阻害剤としてのガンマ−ヒドロキシ−２−（フルオロアルキルアミノカルボニル）−１−ピペラジンペンタンアミド類 |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097490A (en) * | 1975-09-25 | 1978-06-27 | Merck & Co., Inc. | Pyroglutamic acid salts of t-butylamino-2,3-dihydroxypropane |
| SU1273359A1 (ru) * | 1985-06-19 | 1986-11-30 | Институт Хлорорганического Синтеза Ан Азсср | 1-Пиперидино-4-(1-метил-2,2-гем.дихлорциклопропил)-2,3-эпоксибутан в качестве противозадирной и противоизносной присадки к смазочным маслам |
| US5026853A (en) * | 1987-04-01 | 1991-06-25 | Janssen Pharmaceutica N.V. | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| US5075337A (en) * | 1989-07-26 | 1991-12-24 | G. D. Searle & Co. | Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders |
| US5218114A (en) * | 1991-04-10 | 1993-06-08 | Merck & Co., Inc. | Cholecystokinin antagonists |
| CA2072237A1 (en) * | 1991-07-02 | 1993-01-03 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral -amino epoxides |
| US5169952A (en) * | 1991-07-02 | 1992-12-08 | Merck & Co., Inc. | Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides |
| SG52731A1 (en) * | 1991-11-08 | 1998-09-28 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| SK282616B6 (sk) * | 1993-07-16 | 2002-10-08 | Merck & Co., Inc. | Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty |
| US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
-
1994
- 1994-07-08 IL IL11025594A patent/IL110255A/en not_active IP Right Cessation
- 1994-07-11 UA UA96010308A patent/UA45317C2/uk unknown
- 1994-07-11 KR KR1019960700292A patent/KR100325279B1/ko not_active Expired - Fee Related
- 1994-07-11 EP EP94923392A patent/EP0708763B1/en not_active Expired - Lifetime
- 1994-07-11 KR KR1020017010994A patent/KR100362800B1/ko not_active Expired - Fee Related
- 1994-07-11 CA CA002167408A patent/CA2167408C/en not_active Expired - Fee Related
- 1994-07-11 WO PCT/US1994/007695 patent/WO1995002583A1/en not_active Ceased
- 1994-07-11 RO RO96-00068A patent/RO117019B1/ro unknown
- 1994-07-11 JP JP7504630A patent/JPH09500131A/ja active Pending
- 1994-07-11 NZ NZ269400A patent/NZ269400A/en unknown
- 1994-07-11 RO ROA200100412A patent/RO117175B1/ro unknown
- 1994-07-11 FI FI960206A patent/FI960206L/fi not_active IP Right Cessation
- 1994-07-11 CN CN94193331A patent/CN1046715C/zh not_active Expired - Fee Related
- 1994-07-11 DE DE69432176T patent/DE69432176T2/de not_active Expired - Fee Related
- 1994-07-11 AU AU73267/94A patent/AU679770B2/en not_active Ceased
- 1994-07-11 CZ CZ96130A patent/CZ13096A3/cs unknown
- 1994-07-11 EP EP03075406A patent/EP1310495A3/en not_active Withdrawn
- 1994-07-11 RO ROA200100414A patent/RO117176B1/ro unknown
- 1994-07-11 ES ES94923392T patent/ES2191683T3/es not_active Expired - Lifetime
- 1994-07-11 RU RU96105392A patent/RU2134263C1/ru not_active IP Right Cessation
- 1994-07-11 HU HU9600078A patent/HUT76789A/hu unknown
- 1994-07-11 AT AT94923392T patent/ATE233249T1/de not_active IP Right Cessation
- 1994-07-15 ZA ZA945194A patent/ZA945194B/xx unknown
-
1995
- 1995-06-07 US US08/474,800 patent/US5693803A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,926 patent/US5618939A/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,626 patent/US5637711A/en not_active Expired - Fee Related
-
1997
- 1997-09-16 US US08/929,970 patent/US5861512A/en not_active Expired - Fee Related
Also Published As
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| CA2167183C (en) | Process for making hiv protease inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |