IL108976A - Expression vectors are controlled by an LP coefficient from Bacteriopa learned - Google Patents

Expression vectors are controlled by an LP coefficient from Bacteriopa learned

Info

Publication number
IL108976A
IL108976A IL10897685A IL10897685A IL108976A IL 108976 A IL108976 A IL 108976A IL 10897685 A IL10897685 A IL 10897685A IL 10897685 A IL10897685 A IL 10897685A IL 108976 A IL108976 A IL 108976A
Authority
IL
Israel
Prior art keywords
plasmid
analog
host
gene
site
Prior art date
Application number
IL10897685A
Other languages
English (en)
Hebrew (he)
Other versions
IL108976A0 (en
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/644,105 external-priority patent/US4742004A/en
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of IL108976A0 publication Critical patent/IL108976A0/xx
Publication of IL108976A publication Critical patent/IL108976A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • C12N15/69Increasing the copy number of the vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/73Expression systems using phage (lambda) regulatory sequences
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL10897685A 1984-08-27 1985-08-26 Expression vectors are controlled by an LP coefficient from Bacteriopa learned IL108976A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US64455184A 1984-08-27 1984-08-27
US64511984A 1984-08-27 1984-08-27
US64467184A 1984-08-27 1984-08-27
US64424584A 1984-08-27 1984-08-27
US06/644,105 US4742004A (en) 1984-08-27 1984-08-27 Method for producing enzymatically active eucaryotic sod in bacteria
IL7619285A IL76192A (en) 1984-08-27 1985-08-26 A method for producing an enzymatic active enzyme of superoxide dismutase of a person from transformed bacteria

Publications (2)

Publication Number Publication Date
IL108976A0 IL108976A0 (en) 1994-06-24
IL108976A true IL108976A (en) 1996-12-05

Family

ID=27542038

Family Applications (3)

Application Number Title Priority Date Filing Date
IL7619285A IL76192A (en) 1984-08-27 1985-08-26 A method for producing an enzymatic active enzyme of superoxide dismutase of a person from transformed bacteria
IL10897685A IL108976A (en) 1984-08-27 1985-08-26 Expression vectors are controlled by an LP coefficient from Bacteriopa learned
IL11003985A IL110039A (en) 1984-08-27 1985-08-26 A method for producing an enzymatic active enzyme of human superoxide dismutase from inspired-transformed bacteria

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL7619285A IL76192A (en) 1984-08-27 1985-08-26 A method for producing an enzymatic active enzyme of superoxide dismutase of a person from transformed bacteria

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11003985A IL110039A (en) 1984-08-27 1985-08-26 A method for producing an enzymatic active enzyme of human superoxide dismutase from inspired-transformed bacteria

Country Status (15)

Country Link
EP (2) EP0173280B1 (el)
JP (4) JP2933280B2 (el)
AT (2) ATE184916T1 (el)
AU (1) AU603331B2 (el)
CA (2) CA1340597C (el)
DE (2) DE3586473T2 (el)
DK (1) DK384185A (el)
GR (1) GR852030B (el)
HK (1) HK151695A (el)
HU (2) HU214977B (el)
IE (1) IE61141B1 (el)
IL (3) IL76192A (el)
MY (1) MY130321A (el)
NZ (1) NZ213154A (el)
PT (1) PT81025B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71689A0 (en) * 1983-04-29 1984-07-31 Yeda Res & Dev Human superoxide dismutase production
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio- Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
EP0340805B1 (en) * 1983-10-03 1997-07-16 Chiron Corporation Superoxide dismutase and expression in microorganisms
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms
JP2594535B2 (ja) * 1984-11-30 1997-03-26 サントリー株式会社 高発現ベクターおよびその利用
US5037806A (en) * 1985-02-22 1991-08-06 Monsanto Company Biologically active method using somatotropins
AU6522486A (en) * 1985-10-04 1987-04-24 Biotechnology Research Partners Limited Recombinant apolipoproteins and methods
GB8701848D0 (en) * 1987-01-28 1987-03-04 Celltech Ltd Polypeptides
IL96136A (en) * 1989-11-07 2000-12-06 Bio Technology General Corp Use of hydrophobic chromatography in a method for purification of copper-zinc superoxide dismutase from cells containing same
WO1991007496A1 (en) * 1989-11-09 1991-05-30 Allied-Signal Inc. Cloning and expression of genes encoding for polypeptides comprised of one or more repeating amino acid sequences
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
GB9303988D0 (en) * 1993-02-26 1993-04-14 Health Lab Service Board Bi-functional expression systems
US6030810A (en) 1997-02-26 2000-02-29 Delgado; Stephen Gregory Cloned tetrodotoxin-sensitive sodium channel α-subunit and a splice variant thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143412C (da) * 1979-05-17 1982-05-24 Forenede Bryggerier As Fremgangsmaade til udvinding af cu,zn-superoxid-dismutase fra gaer
PH22618A (en) * 1980-06-06 1988-10-28 Biogen Nv Improved vectors and method for making such vectors and for expressing cloned genes
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
CA1341012C (en) * 1982-09-27 2000-06-06 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides
WO1984002918A1 (fr) * 1983-01-21 1984-08-02 Transgene Sa NOUVEAUX VECTEURS D'EXPRESSION ET LEUR APPLICATION A LA PREPARATION D'UNE PROTEINE AYANT L'ACTIVITE DE L'ANTITRYPSINE-alpha1 HUMAINE
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio- Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
EP0138111B1 (en) * 1983-10-03 1991-11-21 Chiron Corporation Superoxide dismutase cloning and expression in microorganisms

Also Published As

Publication number Publication date
CA1340464C (en) 1999-03-23
JPH08283296A (ja) 1996-10-29
DE3588216T2 (de) 2000-02-03
HUT40697A (en) 1987-01-28
IL108976A0 (en) 1994-06-24
ATE184916T1 (de) 1999-10-15
AU4667785A (en) 1986-03-06
HU215160B (hu) 1998-10-28
EP0483113B1 (en) 1999-09-22
IE61141B1 (en) 1994-10-05
JPH07236490A (ja) 1995-09-12
IL110039A (en) 1996-12-05
DE3588216D1 (de) 1999-10-28
DE3586473T2 (de) 1993-02-04
CA1340597C (en) 1999-06-22
EP0483113A3 (en) 1992-05-13
IE852093L (en) 1986-02-27
JPH07222596A (ja) 1995-08-22
IL76192A0 (en) 1985-12-31
EP0173280B1 (en) 1992-08-12
HU214977B (hu) 1998-08-28
IL76192A (en) 1996-12-05
PT81025A (en) 1985-09-01
GR852030B (el) 1985-12-30
DK384185A (da) 1986-02-28
NZ213154A (en) 1988-11-29
JP2777074B2 (ja) 1998-07-16
MY130321A (en) 2007-06-29
EP0173280A1 (en) 1986-03-05
IL110039A0 (en) 1994-10-07
DE3586473D1 (de) 1992-09-17
EP0483113A2 (en) 1992-04-29
AU603331B2 (en) 1990-11-15
ATE79407T1 (de) 1992-08-15
PT81025B (pt) 1988-01-22
JP2933280B2 (ja) 1999-08-09
HK151695A (en) 1995-09-29
DK384185D0 (da) 1985-08-23
JPS61111693A (ja) 1986-05-29
JP2688180B2 (ja) 1997-12-08

Similar Documents

Publication Publication Date Title
US5457042A (en) Sod polypeptide analogs
US5143836A (en) Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US6030611A (en) Therapeutic SOD compositions and uses thereof
AU671728B2 (en) Methods of production of analogues of human Cu/Zn superoxide dismutase
EP0131843B1 (en) Expression vectors for enhanced production of polypeptides, plasmids containing the vectors, hosts containing the plasmids, products manufactured thereby and related methods
EP0173280B1 (en) Plasmids containing lambda pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, hosts containing the plasmids and related methods
JP2609449B2 (ja) ヒトマンガンスーパーオキシドジスムターゼ▲下c▼DNA、その細菌中での発現及び酵素活性ヒトマンガンスーパーオキシドジスムターゼの回収方法
US5256546A (en) Bacterial expression of porcine growth hormone
US5527691A (en) Expression vectors containing lambdapl promoter and T1 T2 rRNA termination sequence, plasmids containing the vectors, hosts containing the plasmids and related methods
US5637495A (en) Plasmids for production of human growth hormone or polypeptide analog thereof, hosts containing the plasmids, products manufactured thereby, and related methods
US5670371A (en) Bacterial expression of superoxide dismutase
US5759816A (en) Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
US5198361A (en) Plasmids for production of met-asp-gln bovine growth hormone, hosts containing the plasmids, products manufactured thereby and related methods
US5112744A (en) Plasmids for the production of human Cu-Zn superoxide dismutase, bacterial hosts containing the plasmids and methods for production and recovery of such superoxide dismutase
US5081020A (en) Expression vectors containing λPL promoter, T1 T2 rRNA termination sequence and origin of replication derived from a constitutive high copy number plasmid hosts and related methods
DD251787A5 (de) Verfahren zur Herstellung eines Polypeptids oder eines Analogen desselben

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
RH Patent void
KB Patent renewed
EXP Patent expired