US5393762A
(en)
*
|
1993-06-04 |
1995-02-28 |
Pfizer Inc. |
Pharmaceutical agents for treatment of emesis
|
EP0655246A1
(en)
*
|
1993-11-30 |
1995-05-31 |
Pfizer Inc. |
Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
|
US5688960A
(en)
*
|
1995-05-02 |
1997-11-18 |
Schering Corporation |
Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
|
US5696267A
(en)
*
|
1995-05-02 |
1997-12-09 |
Schering Corporation |
Substituted oximes, hydrazones and olefins as neurokinin antagonists
|
TW458774B
(en)
|
1995-10-20 |
2001-10-11 |
Pfizer |
Antiemetic pharmaceutical compositions
|
EP1019410A1
(en)
*
|
1995-11-23 |
2000-07-19 |
MERCK SHARP & DOHME LTD. |
Spiro-piperidine derivatives and their use as tachykinin antagonists
|
GB9603136D0
(en)
*
|
1996-02-15 |
1996-04-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9603137D0
(en)
*
|
1996-02-15 |
1996-04-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
EP0888286B1
(en)
*
|
1996-03-14 |
2001-10-31 |
Warner-Lambert Company |
Novel substituted cyclic amino acids as pharmaceutical agents
|
PL330235A1
(en)
*
|
1996-06-21 |
1999-05-10 |
Merck Sharp & Dohme |
Derivatives of spiropiperidine and their application as therapeutic agents
|
GB9613969D0
(en)
*
|
1996-07-03 |
1996-09-04 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6046195A
(en)
*
|
1996-09-25 |
2000-04-04 |
Merck Sharp & Dohme Ltd. |
Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
|
US5929094A
(en)
*
|
1996-10-25 |
1999-07-27 |
Merck & Co., Inc. |
Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
|
GB9625843D0
(en)
*
|
1996-12-12 |
1997-01-29 |
Merck & Co Inc |
Phenyl spiroethercycloalkyl tachykinn receptor antagonists
|
US5789422A
(en)
*
|
1996-10-28 |
1998-08-04 |
Schering Corporation |
Substituted arylalkylamines as neurokinin antagonists
|
US5945428A
(en)
*
|
1996-11-01 |
1999-08-31 |
Schering Corporation |
Substituted oximes, hydrazones and olefins as neurokinin antagonists
|
EP0942731B1
(en)
*
|
1996-12-02 |
2004-11-17 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating substance use disorders
|
GB9708484D0
(en)
*
|
1997-04-25 |
1997-06-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9711114D0
(en)
*
|
1997-05-29 |
1997-07-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
US7101547B1
(en)
|
1999-01-22 |
2006-09-05 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies
|
GB9902881D0
(en)
*
|
1999-02-09 |
1999-03-31 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2324116A1
(en)
*
|
1999-10-25 |
2001-04-25 |
Susan Beth Sobolov-Jaynes |
Nk-1 receptor antagonists and eletriptan for the treatment of migraine
|
EP1241257A4
(en)
*
|
1999-12-21 |
2005-03-16 |
Takeda Pharmaceutical |
TACHYKININ-SIMILAR POLYPEPTIDES AND ITS APPLICATION
|
US20020049211A1
(en)
*
|
2000-09-06 |
2002-04-25 |
Sobolov-Jaynes Susan Beth |
Combination treatment for depression and anxiety
|
EP1192952A3
(en)
*
|
2000-09-28 |
2003-03-26 |
Pfizer Products Inc. |
Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
|
JP2005504029A
(ja)
*
|
2001-07-20 |
2005-02-10 |
ファイザー・プロダクツ・インク |
犬の好ましくない行動を改善するためのnk−1受容体アンタゴニストの使用
|
KR101412339B1
(ko)
|
2004-07-15 |
2014-06-25 |
알바니 몰레큘라 리써치, 인크. |
아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를차단하기 위한 용도
|
JP2008510711A
(ja)
*
|
2004-08-20 |
2008-04-10 |
ターガセプト,インコーポレイテッド |
嗜癖治療におけるn−アリールジアザスピラ環状化合物の使用
|
US8362075B2
(en)
|
2005-05-17 |
2013-01-29 |
Merck Sharp & Dohme Corp. |
Cyclohexyl sulphones for treatment of cancer
|
NZ565111A
(en)
|
2005-07-15 |
2011-10-28 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
WO2007041052A2
(en)
|
2005-09-29 |
2007-04-12 |
Merck & Co., Inc. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
WO2008039327A2
(en)
|
2006-09-22 |
2008-04-03 |
Merck & Co., Inc. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
WO2008084261A1
(en)
|
2007-01-10 |
2008-07-17 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
|
US8106086B2
(en)
|
2007-04-02 |
2012-01-31 |
Msd K.K. |
Indoledione derivative
|
EP2170076B1
(en)
|
2007-06-27 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
CA2717509A1
(en)
|
2008-03-03 |
2009-09-11 |
Tiger Pharmatech |
Tyrosine kinase inhibitors
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
CN102595902B
(zh)
|
2009-05-12 |
2015-04-29 |
阿尔巴尼分子研究公司 |
7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
|
WO2010132487A1
(en)
|
2009-05-12 |
2010-11-18 |
Bristol-Myers Squibb Company |
CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
|
ES2446971T3
(es)
|
2009-05-12 |
2014-03-11 |
Albany Molecular Research, Inc. |
Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
|
NZ599343A
(en)
|
2009-10-14 |
2014-05-30 |
Merck Sharp & Dohme |
Substituted piperidines that increase p53 activity and the uses thereof
|
SG186885A1
(en)
|
2010-06-04 |
2013-02-28 |
Albany Molecular Res Inc |
Glycine transporter-1 inhibitors, methods of making them, and uses thereof
|
WO2011163330A1
(en)
|
2010-06-24 |
2011-12-29 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
US8518907B2
(en)
|
2010-08-02 |
2013-08-27 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
RU2624045C2
(ru)
|
2010-08-17 |
2017-06-30 |
Сирна Терапьютикс,Инк |
ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
WO2012036997A1
(en)
|
2010-09-16 |
2012-03-22 |
Schering Corporation |
Fused pyrazole derivatives as novel erk inhibitors
|
WO2012058210A1
(en)
|
2010-10-29 |
2012-05-03 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
US20140045832A1
(en)
|
2011-04-21 |
2014-02-13 |
Piramal Enterprises Limited |
Insulin-Like Growth Factor-1 Receptor Inhibitors
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
EP3358013B1
(en)
|
2012-05-02 |
2020-06-24 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
US9233979B2
(en)
|
2012-09-28 |
2016-01-12 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
EP3610890A1
(en)
|
2012-11-14 |
2020-02-19 |
The Johns Hopkins University |
Methods and compositions for treating schizophrenia
|
PT2925888T
(pt)
|
2012-11-28 |
2017-12-13 |
Merck Sharp & Dohme |
Composições e métodos para tratamento do cancro
|
CA2895504A1
(en)
|
2012-12-20 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as hdm2 inhibitors
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|