IL107564A - Nucleic acid encoding PstS variants method for production and method for controlling polypeptide production in bacteria transformed by said nucleic acid - Google Patents
Nucleic acid encoding PstS variants method for production and method for controlling polypeptide production in bacteria transformed by said nucleic acidInfo
- Publication number
- IL107564A IL107564A IL10756493A IL10756493A IL107564A IL 107564 A IL107564 A IL 107564A IL 10756493 A IL10756493 A IL 10756493A IL 10756493 A IL10756493 A IL 10756493A IL 107564 A IL107564 A IL 107564A
- Authority
- IL
- Israel
- Prior art keywords
- nucleic acid
- psts
- production
- polypeptide
- phosphate
- Prior art date
Links
- 108020004707 nucleic acids Proteins 0.000 title abstract 7
- 102000039446 nucleic acids Human genes 0.000 title abstract 7
- 150000007523 nucleic acids Chemical class 0.000 title abstract 7
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 241000894006 Bacteria Species 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 abstract 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 229910052816 inorganic phosphate Inorganic materials 0.000 abstract 2
- 101150099106 pstS gene Proteins 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 abstract 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 abstract 1
- 101100084022 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) lapA gene Proteins 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/989,845 US5304472A (en) | 1992-11-20 | 1992-11-20 | Method of controlling polypeptide production in bacterial cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL107564A0 IL107564A0 (en) | 1994-02-27 |
| IL107564A true IL107564A (en) | 2000-08-31 |
Family
ID=25535525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10756493A IL107564A (en) | 1992-11-20 | 1993-11-10 | Nucleic acid encoding PstS variants method for production and method for controlling polypeptide production in bacteria transformed by said nucleic acid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5304472A (xx) |
| EP (1) | EP0669980B1 (xx) |
| JP (1) | JP3503705B2 (xx) |
| AT (1) | ATE247167T1 (xx) |
| AU (1) | AU671512B2 (xx) |
| CA (1) | CA2145388C (xx) |
| DE (1) | DE69333145T2 (xx) |
| DK (1) | DK0669980T3 (xx) |
| ES (1) | ES2204911T3 (xx) |
| IL (1) | IL107564A (xx) |
| PT (1) | PT669980E (xx) |
| WO (1) | WO1994012636A1 (xx) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789199A (en) * | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US6140305A (en) * | 1996-04-04 | 2000-10-31 | Bio-Rad Laboratories, Inc. | Hereditary hemochromatosis gene products |
| WO1997038123A1 (en) * | 1996-04-05 | 1997-10-16 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells |
| IL129843A0 (en) * | 1996-11-08 | 2000-02-29 | Cytel Corp | Improved expression vectors |
| US6083715A (en) * | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| EP1141313A2 (en) * | 1998-12-31 | 2001-10-10 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| WO2000039303A2 (en) * | 1998-12-31 | 2000-07-06 | Chiron Corporation | Modified hiv env polypeptides |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| DE10012283A1 (de) * | 2000-03-14 | 2001-09-20 | Thomas Schweder | Wirts-Vektor-Systeme zur phosphatregulierten Überproduktion von Polypeptiden in Becillus |
| EP2292772A1 (en) * | 2001-07-05 | 2011-03-09 | Novartis Vaccines and Diagnostics, Inc. | HIV vaccination with a DNA encoding a HIV polypeptide and a HIV polypeptide |
| AU2002320314A1 (en) * | 2001-07-05 | 2003-01-21 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US7858762B2 (en) | 2001-07-30 | 2010-12-28 | Genencor International, Inc. | Phosphate limited inducible promoter and a Bacillus expression system |
| WO2003020876A2 (en) | 2001-08-31 | 2003-03-13 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
| US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| DK1432793T3 (da) * | 2001-09-13 | 2009-12-07 | Genentech Inc | Aminopeptidase b2324 |
| GB0224082D0 (en) * | 2002-10-16 | 2002-11-27 | Celltech R&D Ltd | Biological products |
| WO2004081033A2 (en) * | 2003-03-11 | 2004-09-23 | National Institutes Of Health | Synthesis of proteins by cell-free protein expression |
| AU2012203817B2 (en) * | 2004-03-11 | 2015-05-28 | Genentech, Inc. | Process for producing polypeptides |
| CA2558911C (en) * | 2004-03-11 | 2016-12-06 | Genentech, Inc. | Process for producing polypeptides |
| CN101128586A (zh) | 2004-12-22 | 2008-02-20 | 健泰科生物技术公司 | 制备可溶性多跨膜蛋白的方法 |
| BRPI0621124A2 (pt) | 2005-12-22 | 2011-11-29 | Genentech Inc | métodos para recuperação de uma proteìna de ligação à heparina |
| US20080213811A1 (en) * | 2006-08-11 | 2008-09-04 | Invitrogen Corporation | Sensor proteins and assay methods |
| GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
| GB201000588D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
| EP2546267A1 (en) | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
| CN103649124B (zh) | 2011-07-13 | 2016-04-13 | Ucb医药有限公司 | 表达重组dsbc的细菌宿主菌株 |
| GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
| EP2970869A4 (en) * | 2013-03-14 | 2016-08-03 | Codexis Inc | REPRESSIBLE PROMOTER WITH LOW PHOSPHATE CONTENT |
| KR102185850B1 (ko) * | 2020-02-21 | 2020-12-02 | 씨제이제일제당 주식회사 | 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS592689A (ja) * | 1982-06-04 | 1984-01-09 | Handai Biseibutsubiyou Kenkyukai | 強力な遺伝子発現能を有する新規レプリコンの作成法 |
| FR2575760A1 (fr) * | 1985-01-04 | 1986-07-11 | Merieux Inst | Nouvelles souches d'escherichia coli excretrices de phosphatase alcaline, procede d'obtention de ces souches, procede de production de phosphatase alcaline et de proteines hybrides derivees |
| JPS61280292A (ja) * | 1985-06-04 | 1986-12-10 | Wakunaga Pharmaceut Co Ltd | 菌体外分泌による蛋白質の製造法 |
| FR2599380A1 (fr) * | 1986-05-29 | 1987-12-04 | Centre Nat Rech Scient | Vecteur d'exportation de proteines chez escherichiacoli, bacteries transformees et procede pour la preparation de proteines |
| FR2606031A1 (fr) * | 1986-11-03 | 1988-05-06 | Merieux Inst | Nouvelles souches d'escherichia coli hyperproductrices et/ou hyperexcretrices de proteines exportees, procede d'obtention de ces souches, et application a la production de proteines |
| DE69127482T2 (de) * | 1990-02-07 | 1998-03-19 | Abbott Lab | Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien |
-
1992
- 1992-11-20 US US07/989,845 patent/US5304472A/en not_active Expired - Lifetime
-
1993
- 1993-11-10 IL IL10756493A patent/IL107564A/xx not_active IP Right Cessation
- 1993-11-19 ES ES94901629T patent/ES2204911T3/es not_active Expired - Lifetime
- 1993-11-19 AU AU56151/94A patent/AU671512B2/en not_active Ceased
- 1993-11-19 DK DK94901629T patent/DK0669980T3/da active
- 1993-11-19 WO PCT/US1993/011298 patent/WO1994012636A1/en active IP Right Grant
- 1993-11-19 JP JP51329494A patent/JP3503705B2/ja not_active Expired - Fee Related
- 1993-11-19 CA CA002145388A patent/CA2145388C/en not_active Expired - Fee Related
- 1993-11-19 AT AT94901629T patent/ATE247167T1/de active
- 1993-11-19 DE DE69333145T patent/DE69333145T2/de not_active Expired - Lifetime
- 1993-11-19 EP EP94901629A patent/EP0669980B1/en not_active Expired - Lifetime
- 1993-11-19 PT PT94901629T patent/PT669980E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0669980A1 (en) | 1995-09-06 |
| WO1994012636A1 (en) | 1994-06-09 |
| JPH08503612A (ja) | 1996-04-23 |
| IL107564A0 (en) | 1994-02-27 |
| ES2204911T3 (es) | 2004-05-01 |
| US5304472A (en) | 1994-04-19 |
| CA2145388C (en) | 2004-08-10 |
| ATE247167T1 (de) | 2003-08-15 |
| AU671512B2 (en) | 1996-08-29 |
| DE69333145D1 (de) | 2003-09-18 |
| DK0669980T3 (da) | 2003-11-24 |
| JP3503705B2 (ja) | 2004-03-08 |
| PT669980E (pt) | 2003-12-31 |
| DE69333145T2 (de) | 2004-06-17 |
| CA2145388A1 (en) | 1994-06-09 |
| EP0669980B1 (en) | 2003-08-13 |
| AU5615194A (en) | 1994-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |