ATE152176T1 - Verfahren zum regeln des norleucingehalts in polypeptiden - Google Patents
Verfahren zum regeln des norleucingehalts in polypeptidenInfo
- Publication number
- ATE152176T1 ATE152176T1 AT89902468T AT89902468T ATE152176T1 AT E152176 T1 ATE152176 T1 AT E152176T1 AT 89902468 T AT89902468 T AT 89902468T AT 89902468 T AT89902468 T AT 89902468T AT E152176 T1 ATE152176 T1 AT E152176T1
- Authority
- AT
- Austria
- Prior art keywords
- norleucine
- polypeptides
- controlling
- methods
- fermentation media
- Prior art date
Links
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 abstract 4
- 230000004151 fermentation Effects 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 3
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 108010006025 bovine growth hormone Proteins 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15727588A | 1988-02-17 | 1988-02-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE152176T1 true ATE152176T1 (de) | 1997-05-15 |
Family
ID=22563048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89902468T ATE152176T1 (de) | 1988-02-17 | 1989-02-07 | Verfahren zum regeln des norleucingehalts in polypeptiden |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP0401254B1 (de) |
| JP (1) | JP2879063B2 (de) |
| AT (1) | ATE152176T1 (de) |
| AU (1) | AU3058489A (de) |
| DE (1) | DE68927997T2 (de) |
| DK (1) | DK181790D0 (de) |
| WO (1) | WO1989007651A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100402649C (zh) | 2000-05-10 | 2008-07-16 | 阿斯比奥制药株式会社 | 在基因重组多肽的生产中抑制副产物生成的方法 |
| AU2004282492B2 (en) | 2003-09-25 | 2011-02-10 | Monsanto Technology Llc | Prevention of incorporation of non-standard amino acids into protein |
| RU2315807C2 (ru) * | 2004-09-10 | 2008-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ НОРЛЕЙЦИНА И НОРВАЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Escherichia, В КОТОРОЙ ВСЕ СИНТАЗЫ АЦЕТОГИДРОКСИКИСЛОТ ИНАКТИВИРОВАНЫ |
| AU2013318047A1 (en) * | 2012-09-19 | 2015-03-12 | Genentech, Inc. | Methods and compositions for preventing norleucine misincorporation into proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443545A (en) * | 1980-08-25 | 1984-04-17 | Massachusetts Institute Of Technology | Process for producing heparinase |
| US5037806A (en) * | 1985-02-22 | 1991-08-06 | Monsanto Company | Biologically active method using somatotropins |
| US4762784A (en) * | 1985-07-15 | 1988-08-09 | International Minerals & Chemical Corp. | Fermemtation process for the high level production of bovine growth hormone |
-
1989
- 1989-02-07 EP EP89902468A patent/EP0401254B1/de not_active Revoked
- 1989-02-07 AT AT89902468T patent/ATE152176T1/de active
- 1989-02-07 WO PCT/US1989/000425 patent/WO1989007651A2/en not_active Application Discontinuation
- 1989-02-07 DE DE68927997T patent/DE68927997T2/de not_active Revoked
- 1989-02-07 JP JP1502300A patent/JP2879063B2/ja not_active Expired - Lifetime
- 1989-02-07 AU AU30584/89A patent/AU3058489A/en not_active Abandoned
- 1989-02-07 EP EP96104679A patent/EP0737752A3/de not_active Ceased
-
1990
- 1990-07-30 DK DK181790A patent/DK181790D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK181790A (da) | 1990-07-30 |
| EP0401254B1 (de) | 1997-04-23 |
| WO1989007651A3 (en) | 1989-11-02 |
| AU3058489A (en) | 1989-09-06 |
| DE68927997T2 (de) | 1997-09-11 |
| EP0401254A1 (de) | 1990-12-12 |
| EP0737752A2 (de) | 1996-10-16 |
| DK181790D0 (da) | 1990-07-30 |
| JPH03502758A (ja) | 1991-06-27 |
| DE68927997D1 (de) | 1997-05-28 |
| JP2879063B2 (ja) | 1999-04-05 |
| WO1989007651A2 (en) | 1989-08-24 |
| EP0737752A3 (de) | 1996-10-23 |
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