DK0669980T3 - Fremgangsmåde til kontrol af polypeptidproduktion i bakterier - Google Patents

Fremgangsmåde til kontrol af polypeptidproduktion i bakterier

Info

Publication number
DK0669980T3
DK0669980T3 DK94901629T DK94901629T DK0669980T3 DK 0669980 T3 DK0669980 T3 DK 0669980T3 DK 94901629 T DK94901629 T DK 94901629T DK 94901629 T DK94901629 T DK 94901629T DK 0669980 T3 DK0669980 T3 DK 0669980T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
polypeptide
phosphate
psts
promoter
Prior art date
Application number
DK94901629T
Other languages
Danish (da)
English (en)
Inventor
Steven Bass
James R Swartz
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0669980T3 publication Critical patent/DK0669980T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK94901629T 1992-11-20 1993-11-19 Fremgangsmåde til kontrol af polypeptidproduktion i bakterier DK0669980T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/989,845 US5304472A (en) 1992-11-20 1992-11-20 Method of controlling polypeptide production in bacterial cells
PCT/US1993/011298 WO1994012636A1 (en) 1992-11-20 1993-11-19 Method of controlling polypeptide production in bacteria

Publications (1)

Publication Number Publication Date
DK0669980T3 true DK0669980T3 (da) 2003-11-24

Family

ID=25535525

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94901629T DK0669980T3 (da) 1992-11-20 1993-11-19 Fremgangsmåde til kontrol af polypeptidproduktion i bakterier

Country Status (12)

Country Link
US (1) US5304472A (xx)
EP (1) EP0669980B1 (xx)
JP (1) JP3503705B2 (xx)
AT (1) ATE247167T1 (xx)
AU (1) AU671512B2 (xx)
CA (1) CA2145388C (xx)
DE (1) DE69333145T2 (xx)
DK (1) DK0669980T3 (xx)
ES (1) ES2204911T3 (xx)
IL (1) IL107564A (xx)
PT (1) PT669980E (xx)
WO (1) WO1994012636A1 (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789199A (en) * 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US6140305A (en) * 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
CA2271230A1 (en) * 1996-11-08 1998-05-14 Cytel Corporation Improved expression vectors
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
AU2487300A (en) * 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
JP4776075B2 (ja) * 1998-12-31 2011-09-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 改変ｈｉｖｅｎｖポリペプチド
US6602705B1 (en) * 1998-12-31 2003-08-05 Chiron Corporation Expression of HIV polypeptides and production of virus-like particles
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
DE10012283A1 (de) * 2000-03-14 2001-09-20 Thomas Schweder Wirts-Vektor-Systeme zur phosphatregulierten Überproduktion von Polypeptiden in Becillus
US7211659B2 (en) * 2001-07-05 2007-05-01 Chiron Corporation Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
EP2292772A1 (en) * 2001-07-05 2011-03-09 Novartis Vaccines and Diagnostics, Inc. HIV vaccination with a DNA encoding a HIV polypeptide and a HIV polypeptide
WO2003054140A2 (en) 2001-07-30 2003-07-03 Genencor International, Inc. Phosphate limited inducible promoter and a bacillus expression system
US20030170614A1 (en) * 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
AU2002316578A1 (en) 2001-08-31 2003-03-18 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
KR100954641B1 (ko) * 2001-09-13 2010-04-27 제넨테크, 인크. 아미노펩티다아제
GB0224082D0 (en) * 2002-10-16 2002-11-27 Celltech R&D Ltd Biological products
WO2004081033A2 (en) * 2003-03-11 2004-09-23 National Institutes Of Health Synthesis of proteins by cell-free protein expression
SI1733037T1 (sl) * 2004-03-11 2015-02-27 Genentech, Inc. Postopek za izdelavo polipeptidov
AU2012203817B2 (en) * 2004-03-11 2015-05-28 Genentech, Inc. Process for producing polypeptides
CA2592390A1 (en) 2004-12-22 2006-06-29 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
US20080032343A1 (en) 2005-12-22 2008-02-07 Genentech, Inc. Recombinant Production of Heparin Binding Proteins
EP2061884A4 (en) * 2006-08-11 2010-03-24 Life Technologies Corp SENSOR PROTEINS AND TEST PROCEDURES THEREFOR
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
EP2546267A1 (en) 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
LT2731973T (lt) 2011-07-13 2018-02-26 Ucb Biopharma Sprl Bakterijų padermė, ekspresuojanti rekombinantinį dsbc
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
CN105189527A (zh) * 2013-03-14 2015-12-23 科德克希思公司 低-磷酸盐可阻遏的启动子
KR102185850B1 (ko) * 2020-02-21 2020-12-02 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS592689A (ja) * 1982-06-04 1984-01-09 Handai Biseibutsubiyou Kenkyukai 強力な遺伝子発現能を有する新規レプリコンの作成法
FR2575760A1 (fr) * 1985-01-04 1986-07-11 Merieux Inst Nouvelles souches d'escherichia coli excretrices de phosphatase alcaline, procede d'obtention de ces souches, procede de production de phosphatase alcaline et de proteines hybrides derivees
JPS61280292A (ja) * 1985-06-04 1986-12-10 Wakunaga Pharmaceut Co Ltd 菌体外分泌による蛋白質の製造法
FR2599380A1 (fr) * 1986-05-29 1987-12-04 Centre Nat Rech Scient Vecteur d'exportation de proteines chez escherichiacoli, bacteries transformees et procede pour la preparation de proteines
FR2606031A1 (fr) * 1986-11-03 1988-05-06 Merieux Inst Nouvelles souches d'escherichia coli hyperproductrices et/ou hyperexcretrices de proteines exportees, procede d'obtention de ces souches, et application a la production de proteines
ATE157702T1 (de) * 1990-02-07 1997-09-15 Abbott Lab Alkalische phosphatase mit verbesserter spezifischer aktivität zur verwendung in indikatorreagenzien

Also Published As

Publication number Publication date
DE69333145T2 (de) 2004-06-17
WO1994012636A1 (en) 1994-06-09
ATE247167T1 (de) 2003-08-15
DE69333145D1 (de) 2003-09-18
EP0669980A1 (en) 1995-09-06
JPH08503612A (ja) 1996-04-23
IL107564A (en) 2000-08-31
PT669980E (pt) 2003-12-31
US5304472A (en) 1994-04-19
ES2204911T3 (es) 2004-05-01
CA2145388C (en) 2004-08-10
IL107564A0 (en) 1994-02-27
AU5615194A (en) 1994-06-22
EP0669980B1 (en) 2003-08-13
AU671512B2 (en) 1996-08-29
CA2145388A1 (en) 1994-06-09
JP3503705B2 (ja) 2004-03-08

Similar Documents

Publication Publication Date Title
DK0669980T3 (da) Fremgangsmåde til kontrol af polypeptidproduktion i bakterier
ES8700320A1 (es) Metodo de obtencion del exprimido de una materia seleccionada que contiene renina.
DK0691405T3 (da) Materialer og fremgangsmåde til hypersecernering af aminosyrer
CA2080920A1 (en) Cloning by complementation and related processes
FI915810A0 (fi) Foerfarande foer doedande av celler utan soenderdelning av cellerna.
HK1017903A1 (en) Process for controlling sialylation of proteins produced by mammalian cell culture.
AU588793B2 (en) Method of expressing alpha-1-antitrypsin in bacteria
AU7126487A (en) Production of proteins by cell culture
FI20095510A (fi) Suuren solutiheyden bakteerifermentaatioviljelmä
DK0698667T3 (da) Xylanase, mikroorganismer til produktion deraf, DNA-molekyler, fremgangsmåder til fremstilling af denne xylanase og anvendelser deraf
DE60331250D1 (de) Mehrere automatische mini-bioreaktoren umfassendes modulares system zum screening mit hohem durchsatz (hts) in der biotechnologie
DE69941789D1 (de) In vivo-verfahren zur herstellung von proteinen, die nicht-konventionelle aminosäuren enthalten
DE68928520D1 (de) Biokontrolle von mikrobiellen Pathogenen
ATE152176T1 (de) Verfahren zum regeln des norleucingehalts in polypeptiden
EP0194626A3 (en) Method for transformation and direct selection of transformants in eucaryotic cells
DE69021005D1 (de) Verfahren zur Kultur von Tomaten-Protoplasten.
ATE288476T1 (de) Herstellung von proteinen
WO2002064811A3 (fr) Procede pour produire des proteines recombinantes, marquees par au moins un isotope
DE58909205D1 (de) Expressionsvektor und Verfahren zur regulierbaren Herstellung von Proteinen in Eukaryonten.
SU1524485A1 (ru) Рекомбинантная плазмидная днк рмм 9, кодирующая синтез белка a staphylococcus aureus, способ ее конструирования и штамм бактерий bacillus subtilis - продуцент белка a staphylococcus aureus
IT1258351B (it) Nuovi costrutti di dna modulati dalla temperatura per la produzione controllata di proteine ricombinati, microorganismi modificati che li contengono e procedimenti che usano questi microorganismi.