IL106797A0 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
IL106797A0
IL106797A0 IL106797A IL10679793A IL106797A0 IL 106797 A0 IL106797 A0 IL 106797A0 IL 106797 A IL106797 A IL 106797A IL 10679793 A IL10679793 A IL 10679793A IL 106797 A0 IL106797 A0 IL 106797A0
Authority
IL
Israel
Prior art keywords
pct
hydroxy
nhch2
sch2
alkylcarbamoyl
Prior art date
Application number
IL106797A
Other languages
English (en)
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL106797A0 publication Critical patent/IL106797A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL106797A 1992-08-28 1993-08-25 Heterocyclic compounds IL106797A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
IL106797A0 true IL106797A0 (en) 1993-12-08

Family

ID=10721113

Family Applications (1)

Application Number Title Priority Date Filing Date
IL106797A IL106797A0 (en) 1992-08-28 1993-08-25 Heterocyclic compounds

Country Status (13)

Country Link
US (1) US5714496A (de)
EP (1) EP0656897B1 (de)
JP (1) JPH08502731A (de)
AT (1) ATE161843T1 (de)
AU (1) AU4969193A (de)
CA (2) CA2143430A1 (de)
DE (1) DE69316224D1 (de)
FI (1) FI950893A (de)
GB (2) GB9218334D0 (de)
IL (1) IL106797A0 (de)
TW (1) TW231293B (de)
WO (1) WO1994005660A1 (de)
ZA (1) ZA936201B (de)

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IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
DE4417837A1 (de) 1994-05-20 1995-11-23 Basf Ag Substituierte 3-Phenylpyrazole
GB9412145D0 (en) * 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
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US6472528B1 (en) * 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
MXPA02003167A (es) * 1999-09-28 2003-10-06 Eisai Co Ltd Compuestos de quinuclidina, y farmacos que contienen los mismos a manera del ingrediente activo.
AU8656101A (en) * 2000-08-21 2002-03-04 Univ Georgetown 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon
ATE366248T1 (de) 2001-03-27 2007-07-15 Eisai R&D Man Co Ltd N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
RU2004110717A (ru) * 2001-10-17 2005-10-20 Юсиби, С.А. (Be) Производные хинуклидина, способы их получения и их применение в качестве и нгибиторов м2- и/или м3- мускариновых рецепторов
GB0127731D0 (en) * 2001-11-20 2002-01-09 Coin Controls Coin handling apparatus
NZ535641A (en) * 2002-05-07 2006-10-27 Neurosearch As Novel azacyclic ethynyl derivatives
CA2510455C (en) 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
CN103724343A (zh) 2004-03-25 2014-04-16 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途
EP2314584A1 (de) * 2004-05-20 2011-04-27 Foldrx Pharmaceuticals, Inc. 2-(heteroaryl)-Benzoxazol-Verbindungen und Derivate, Zusammensetzungen und Verfahren zur Stabilisierung von Transthyretin und zur Hemmung von Transthyretin-Fehlfaltung
US7772271B2 (en) * 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
AU2005275181A1 (en) * 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) * 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7645881B2 (en) * 2004-07-22 2010-01-12 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
AU2006275514B2 (en) 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
CA2676984C (en) 2007-02-01 2015-03-17 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
ES2542835T3 (es) 2009-01-08 2015-08-12 Resverlogix Corporation Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
JP5795304B2 (ja) 2009-03-18 2015-10-14 レスバーロジックス コーポレイション 新規抗炎症剤
KR101892987B1 (ko) 2009-04-22 2018-08-30 리스버로직스 코퍼레이션 신규한 소염제
WO2013038351A1 (en) 2011-09-16 2013-03-21 Pfizer Inc. Solid forms of a transthyretin dissociation inhibitor
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
EP2935253B1 (de) 2012-12-21 2018-08-01 Zenith Epigenetics Ltd. Neuartige heterocyclische verbindungen als bromdomänenhemmer
CA2977308A1 (en) 2015-03-13 2016-09-22 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

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US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
WO1992015579A1 (en) * 1991-03-08 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
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GB9202443D0 (en) * 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof
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Also Published As

Publication number Publication date
ZA936201B (en) 1994-02-28
DE69316224D1 (de) 1998-02-12
ATE161843T1 (de) 1998-01-15
FI950893A0 (fi) 1995-02-27
EP0656897A1 (de) 1995-06-14
GB9317153D0 (en) 1993-10-06
GB9218334D0 (en) 1992-10-14
WO1994005660A1 (en) 1994-03-17
CA2104981A1 (en) 1994-03-01
AU4969193A (en) 1994-03-29
JPH08502731A (ja) 1996-03-26
CA2143430A1 (en) 1994-03-17
FI950893A (fi) 1995-02-27
TW231293B (de) 1994-10-01
EP0656897B1 (de) 1998-01-07
US5714496A (en) 1998-02-03

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