DE69320911D1 - Chinuclidine derivate als squalen synthase inhibitore - Google Patents

Chinuclidine derivate als squalen synthase inhibitore

Info

Publication number
DE69320911D1
DE69320911D1 DE69320911T DE69320911T DE69320911D1 DE 69320911 D1 DE69320911 D1 DE 69320911D1 DE 69320911 T DE69320911 T DE 69320911T DE 69320911 T DE69320911 T DE 69320911T DE 69320911 D1 DE69320911 D1 DE 69320911D1
Authority
DE
Germany
Prior art keywords
alkylcarbamoyl
alkylamino
hydroxy
hydrogen
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69320911T
Other languages
English (en)
Other versions
DE69320911T2 (de
Inventor
George Robert Brown
Keith Blakeney Mallion
Peter Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69320911D1 publication Critical patent/DE69320911D1/de
Application granted granted Critical
Publication of DE69320911T2 publication Critical patent/DE69320911T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69320911T 1992-04-10 1993-04-08 Chinuclidine derivate als squalen synthase inhibitore Expired - Fee Related DE69320911T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929207961A GB9207961D0 (en) 1992-04-10 1992-04-10 Heterocyclic derivatives
PCT/GB1993/000743 WO1993021183A1 (en) 1992-04-10 1993-04-08 Quinuclidine derivatives as squalene synthase inhibitors

Publications (2)

Publication Number Publication Date
DE69320911D1 true DE69320911D1 (de) 1998-10-15
DE69320911T2 DE69320911T2 (de) 1999-04-15

Family

ID=10713853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320911T Expired - Fee Related DE69320911T2 (de) 1992-04-10 1993-04-08 Chinuclidine derivate als squalen synthase inhibitore

Country Status (8)

Country Link
EP (1) EP0596057B1 (de)
JP (1) JPH06511015A (de)
AT (1) ATE170857T1 (de)
AU (1) AU3900693A (de)
CA (1) CA2093782A1 (de)
DE (1) DE69320911T2 (de)
GB (1) GB9207961D0 (de)
WO (1) WO1993021183A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226577D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic derivatives
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
MXPA02003167A (es) * 1999-09-28 2003-10-06 Eisai Co Ltd Compuestos de quinuclidina, y farmacos que contienen los mismos a manera del ingrediente activo.
US6401329B1 (en) 1999-12-21 2002-06-11 Vishay Dale Electronics, Inc. Method for making overlay surface mount resistor
ATE366248T1 (de) * 2001-03-27 2007-07-15 Eisai R&D Man Co Ltd N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
US8226675B2 (en) 2007-03-22 2012-07-24 Ethicon Endo-Surgery, Inc. Surgical instruments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015579A1 (en) * 1991-03-08 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors

Also Published As

Publication number Publication date
EP0596057A1 (de) 1994-05-11
AU3900693A (en) 1993-11-18
CA2093782A1 (en) 1993-10-11
DE69320911T2 (de) 1999-04-15
WO1993021183A1 (en) 1993-10-28
ATE170857T1 (de) 1998-09-15
GB9207961D0 (en) 1992-05-27
EP0596057B1 (de) 1998-09-09
JPH06511015A (ja) 1994-12-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee