IL106592A - Peptides and analogues and their mixtures for the detection and isolation of antibodies to the E1 and E2 protein of the rubella virus - Google Patents
Peptides and analogues and their mixtures for the detection and isolation of antibodies to the E1 and E2 protein of the rubella virusInfo
- Publication number
- IL106592A IL106592A IL10659293A IL10659293A IL106592A IL 106592 A IL106592 A IL 106592A IL 10659293 A IL10659293 A IL 10659293A IL 10659293 A IL10659293 A IL 10659293A IL 106592 A IL106592 A IL 106592A
- Authority
- IL
- Israel
- Prior art keywords
- peptide
- bch
- peptides
- rubella
- mixture
- Prior art date
Links
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- 239000000185 hemagglutinin Substances 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229920000592 inorganic polymer Polymers 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 208000018555 lymphatic system disease Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- IOPLHGOSNCJOOO-UHFFFAOYSA-N methyl 3,4-diaminobenzoate Chemical compound COC(=O)C1=CC=C(N)C(N)=C1 IOPLHGOSNCJOOO-UHFFFAOYSA-N 0.000 description 1
- 208000004141 microcephaly Diseases 0.000 description 1
- 208000030247 mild fever Diseases 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- ZVEZMVFBMOOHAT-UHFFFAOYSA-N nonane-1-thiol Chemical group CCCCCCCCCS ZVEZMVFBMOOHAT-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000009021 pre-vaccination Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000012421 spiking Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- ZERULLAPCVRMCO-UHFFFAOYSA-N sulfure de di n-propyle Natural products CCCSCCC ZERULLAPCVRMCO-UHFFFAOYSA-N 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000002374 tyrosine Nutrition 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36211—Rubivirus, e.g. rubella virus
- C12N2770/36222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/927,071 US5427792A (en) | 1989-08-23 | 1992-08-07 | Peptides, analogues and mixtures thereof for detecting and eliciting antibodies to the E1 and E2 protein of rubella virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106592A0 IL106592A0 (en) | 1993-12-08 |
| IL106592A true IL106592A (en) | 2001-01-11 |
Family
ID=25454125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10659293A IL106592A (en) | 1992-08-07 | 1993-08-04 | Peptides and analogues and their mixtures for the detection and isolation of antibodies to the E1 and E2 protein of the rubella virus |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5427792A (pt) |
| EP (1) | EP0656013B1 (pt) |
| JP (1) | JP3492686B2 (pt) |
| AP (1) | AP453A (pt) |
| AT (1) | ATE192163T1 (pt) |
| AU (1) | AU690070B2 (pt) |
| CA (1) | CA2141670C (pt) |
| DE (1) | DE69328488T2 (pt) |
| ES (1) | ES2145055T3 (pt) |
| IL (1) | IL106592A (pt) |
| PT (1) | PT656013E (pt) |
| WO (1) | WO1994003490A1 (pt) |
| ZA (1) | ZA935642B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2238660A1 (en) * | 1998-05-22 | 1999-11-22 | Janet Chantler | Gene sequences of rubella virus associated with attenuation |
| EP1135684B1 (en) * | 1998-12-01 | 2006-01-11 | Viral Antigens, Inc. | IMPROVED SPECIFICITY IN THE DETECTION OF ANTI-RUBELLA IgM ANTIBODIES |
| BR102018075339A2 (pt) * | 2018-12-06 | 2021-11-16 | Fundação Oswaldo Cruz | Proteína recombinante, sequência de dna sintético, vetor de expressão, célula hospedeira, composição, kit para diagnóstico de rubéola, uso de pelo menos uma proteína recombinante, e, métodos para produzir uma proteína recombinante e para diagnóstico de rubéola |
| CN110423272A (zh) * | 2019-08-15 | 2019-11-08 | 捷敏(天津)生物技术有限公司 | 一种新的抗风疹病毒膜蛋白e1的抗体及其应用技术领域 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU592142B2 (en) * | 1985-11-25 | 1990-01-04 | Cytogen Corporation | Modified viral glycoproteins, diagnostic and therapeutic uses therefore |
| GB2206587A (en) * | 1987-07-08 | 1989-01-11 | London Biotechnology Ltd | Rubella e1 glycoprotein antigens |
| US5164481A (en) * | 1989-08-23 | 1992-11-17 | Iaf Biochem International Inc. | Peptides and analogues and mixtures thereof for detecting and eliciting antibodies to rubella virus |
| GB9201139D0 (en) * | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
-
1992
- 1992-08-07 US US07/927,071 patent/US5427792A/en not_active Expired - Lifetime
-
1993
- 1993-07-30 AT AT93917473T patent/ATE192163T1/de not_active IP Right Cessation
- 1993-07-30 CA CA002141670A patent/CA2141670C/en not_active Expired - Fee Related
- 1993-07-30 ES ES93917473T patent/ES2145055T3/es not_active Expired - Lifetime
- 1993-07-30 EP EP93917473A patent/EP0656013B1/en not_active Expired - Lifetime
- 1993-07-30 AU AU46934/93A patent/AU690070B2/en not_active Ceased
- 1993-07-30 DE DE69328488T patent/DE69328488T2/de not_active Expired - Fee Related
- 1993-07-30 WO PCT/CA1993/000306 patent/WO1994003490A1/en active IP Right Grant
- 1993-07-30 PT PT93917473T patent/PT656013E/pt unknown
- 1993-07-30 JP JP50484894A patent/JP3492686B2/ja not_active Expired - Fee Related
- 1993-08-04 IL IL10659293A patent/IL106592A/en not_active IP Right Cessation
- 1993-08-04 ZA ZA935642A patent/ZA935642B/xx unknown
- 1993-08-06 AP APAP/P/1993/000556A patent/AP453A/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IL106592A0 (en) | 1993-12-08 |
| ATE192163T1 (de) | 2000-05-15 |
| AU690070B2 (en) | 1998-04-23 |
| AP9300556A0 (en) | 1993-10-31 |
| JP3492686B2 (ja) | 2004-02-03 |
| AP453A (en) | 1996-01-20 |
| WO1994003490A1 (en) | 1994-02-17 |
| CA2141670A1 (en) | 1994-02-17 |
| EP0656013A1 (en) | 1995-06-07 |
| CA2141670C (en) | 2007-03-06 |
| ZA935642B (en) | 1995-02-06 |
| PT656013E (pt) | 2000-10-31 |
| JPH08502724A (ja) | 1996-03-26 |
| DE69328488T2 (de) | 2000-11-30 |
| DE69328488D1 (de) | 2000-05-31 |
| AU4693493A (en) | 1994-03-03 |
| US5427792A (en) | 1995-06-27 |
| ES2145055T3 (es) | 2000-07-01 |
| EP0656013B1 (en) | 2000-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |