IL105614A - Antibodies to p-selectin and their uses - Google Patents

Antibodies to p-selectin and their uses

Info

Publication number
IL105614A
IL105614A IL10561493A IL10561493A IL105614A IL 105614 A IL105614 A IL 105614A IL 10561493 A IL10561493 A IL 10561493A IL 10561493 A IL10561493 A IL 10561493A IL 105614 A IL105614 A IL 105614A
Authority
IL
Israel
Prior art keywords
selectin
antibody
blocking
cells
antibodies
Prior art date
Application number
IL10561493A
Other languages
English (en)
Other versions
IL105614A0 (en
Original Assignee
Cytel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytel Corp filed Critical Cytel Corp
Publication of IL105614A0 publication Critical patent/IL105614A0/xx
Priority to US08/964,690 priority Critical patent/US6033667A/en
Publication of IL105614A publication Critical patent/IL105614A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL10561493A 1992-05-05 1993-05-05 Antibodies to p-selectin and their uses IL105614A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US08/964,690 US6033667A (en) 1992-05-05 1997-11-05 Method for detecting the presence of P-selectin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88019692A 1992-05-05 1992-05-05

Publications (2)

Publication Number Publication Date
IL105614A0 IL105614A0 (en) 1993-09-22
IL105614A true IL105614A (en) 1999-06-20

Family

ID=25375701

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10561493A IL105614A (en) 1992-05-05 1993-05-05 Antibodies to p-selectin and their uses

Country Status (11)

Country Link
EP (1) EP0642356B1 (de)
JP (2) JP3720352B2 (de)
AT (1) ATE237353T1 (de)
AU (1) AU681850B2 (de)
CA (1) CA2135083C (de)
DE (1) DE69332881T2 (de)
DK (1) DK0642356T3 (de)
ES (1) ES2197150T3 (de)
IL (1) IL105614A (de)
NZ (2) NZ286804A (de)
WO (1) WO1993021956A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025067A1 (en) * 1993-05-04 1994-11-10 Cytel Corporation Antibodies to p-selectin and their uses
CA2139385C (en) * 1994-02-04 2001-12-25 Gottfried Alber Products containing g-csf and tnf binding protein
WO1996040942A1 (en) * 1995-06-07 1996-12-19 Cytel Corporation Humanized antibodies to e-selectin
JPH0940582A (ja) * 1995-07-28 1997-02-10 Sumitomo Pharmaceut Co Ltd 神経障害治療剤
WO2005100402A1 (en) 2004-04-13 2005-10-27 F.Hoffmann-La Roche Ag Anti-p-selectin antibodies
PL2662091T3 (pl) * 2006-12-01 2019-05-31 Novartis Ag Przeciwciała skierowane przeciwko selektynie P i sposoby ich zastosowania do leczenia chorób zapalnych
US20110212096A1 (en) 2006-12-01 2011-09-01 Scott Rollins Anti-p-selectin antibodies and methods of their use and identification
US8945565B2 (en) 2006-12-01 2015-02-03 Selexys Pharmaceuticals Corporation Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
PE20110302A1 (es) 2008-09-19 2011-05-21 Hoffmann La Roche Formulacion farmaceutica de un anticuerpo contra p-selectina
TW201839136A (zh) 2017-02-06 2018-11-01 瑞士商諾華公司 治療血色素異常症之組合物及方法
US20200087403A1 (en) 2017-03-15 2020-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions for the treatment of thrombosis in patients suffering from a myeloproliferative neoplasm
ES2911600T3 (es) 2017-06-20 2022-05-20 Inst Nat Sante Rech Med Métodos para identificar si pacientes con insuficiencia cardiaca aguda descompensada (ICAD) presentan un estado hipercoagulable
WO2019025847A1 (en) 2017-08-04 2019-02-07 Novartis Ag TREATMENT DIAGRAMS
RU2020132460A (ru) 2018-03-08 2022-04-08 Новартис Аг Применение антитела к p-селектину
US20220306749A1 (en) 2019-06-07 2022-09-29 Novartis Ag Use of an Anti-P-selectin Antibody
AU2020326490A1 (en) 2019-08-08 2022-03-24 Novartis Ag Use of the anti-P-selectin antibody crizanlizumab for treating sickle cell nephropathy and chronic kidney disease associated with sickle cell disease
JP7846007B2 (ja) 2019-12-18 2026-04-14 ノバルティス アーゲー 異常ヘモグロビン症の治療用組成物及び方法
US20250127809A1 (en) 2021-06-23 2025-04-24 Novartis Ag Compositions and methods for the treatment of hemoglobinopathies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
NO873164L (no) * 1986-07-30 1988-02-01 Teijin Ltd Muse-humane kimaere antistoffer.
JPH05504470A (ja) * 1989-10-20 1993-07-15 ニューイングランド・メディカル・センター・ホスピタルズ・インコーポレーテッド Ｐａｄｇｅｍを介した細胞結合の阻害
DK0714912T3 (da) * 1990-07-17 2003-02-03 Univ Oklahoma Funktionelt aktive selektin-deriverede peptider og ligander for GMP-140
WO1995012125A1 (en) * 1993-10-26 1995-05-04 Mayo Foundation For Medical Education And Research Direct fluorescence-conjugated immunoassay for platelet activation
WO1995030001A2 (en) * 1994-04-28 1995-11-09 Genetics Institute, Inc. Novel p-selectin ligand protein

Also Published As

Publication number Publication date
NZ252542A (en) 1997-08-22
AU681850B2 (en) 1997-09-11
EP0642356A1 (de) 1995-03-15
IL105614A0 (en) 1993-09-22
ES2197150T3 (es) 2004-01-01
ATE237353T1 (de) 2003-05-15
JP3720352B2 (ja) 2005-11-24
NZ286804A (en) 2000-08-25
WO1993021956A1 (en) 1993-11-11
CA2135083A1 (en) 1993-11-11
JPH08503360A (ja) 1996-04-16
CA2135083C (en) 2004-01-06
DE69332881D1 (de) 2003-05-22
EP0642356A4 (de) 1998-05-27
EP0642356B1 (de) 2003-04-16
DE69332881T2 (de) 2004-01-29
AU4236093A (en) 1993-11-29
DK0642356T3 (da) 2003-08-04
JP2006045234A (ja) 2006-02-16

Similar Documents

Publication Publication Date Title
EP0642356B1 (de) Antikörper gegen p-selectin und ihre verwendung
US5800815A (en) Antibodies to P-selectin and their uses
US7060271B2 (en) Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
EP0314863B1 (de) Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen
ES2262186T5 (es) Inmunoglobulina humanizada reactiva con integrina alpha4beta7
US7033796B2 (en) Nucleic acids encoding protein tyrosine kinases
US6316604B1 (en) Human C3b/C4b receptor (CR1)
CA1340866C (en) Human c3b/c4b receptor (cr1)
US5981481A (en) Human C3b/C4b receptor (CR1)
JP4237711B2 (ja) 新規ｐ−セレクチンリガンド蛋白
IE903447A1 (en) THE HUMAN C3b/C4b RECEPTOR (CR1)
Tojo et al. Reduction of rat myocardial ischemia and reperfusion injury by sialyl Lewis x oligosaccharide and anti-rat P-selectin antibodies
CZ288789B6 (cs) Polynukleotidová sekvence kódující protokadherin, DNA vektor, hostitelská buňka, protokadherin, způsob jeho produkce, protilátková substance, buněčná linie a způsob modulace vazebné aktivity protokadherinu
JP3455743B2 (ja) ヒトｐｄｇｆベータ・レセプタに対する阻害性免疫グロブリン・ポリペプチド
US20160304612A1 (en) Anti-P Selectin Antibodies and Methods of Their Use and Identification
EP0804235A1 (de) Antikörper gegen p-selectin und ihre verwendungen
KR970007783B1 (ko) 특이적 결합제
US5599676A (en) Method for isolating a novel receptor for α4 integrins
AU5657898A (en) Junctional adhesion molecule (jam), a transmembrane protein of tight junctions
EP0505749A2 (de) Gegen aktivierte Endothelialzellen gerichtete monoklonale Antikörper und deren therapeutische und diagnostische Verwendung
US6033667A (en) Method for detecting the presence of P-selectin
CA2162149C (en) Antibodies to p-selectin and their uses
CA3158862A1 (en) Polypeptide inhibitors of neutrophil elastase activity and uses thereof
IE83449B1 (en) Cell growth inhibitors
AU684084B2 (en) Antibodies to P-selectin and their uses

Legal Events

Date Code Title Description
FF Patent granted
FF Patent granted
HC Change of name of proprietor(s)
HP Change in proprietorship
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees