IL102856A - Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl - - Google Patents

Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl -

Info

Publication number
IL102856A
IL102856A IL10285692A IL10285692A IL102856A IL 102856 A IL102856 A IL 102856A IL 10285692 A IL10285692 A IL 10285692A IL 10285692 A IL10285692 A IL 10285692A IL 102856 A IL102856 A IL 102856A
Authority
IL
Israel
Prior art keywords
methyl
methoxy
indol
methanol
compound
Prior art date
Application number
IL10285692A
Other languages
English (en)
Hebrew (he)
Other versions
IL102856A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL102856A0 publication Critical patent/IL102856A0/xx
Publication of IL102856A publication Critical patent/IL102856A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL10285692A 1991-09-05 1992-08-18 Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl - IL102856A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919119001A GB9119001D0 (en) 1991-09-05 1991-09-05 Pharmaceutical agents

Publications (2)

Publication Number Publication Date
IL102856A0 IL102856A0 (en) 1993-01-31
IL102856A true IL102856A (en) 1996-12-05

Family

ID=10700953

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10285692A IL102856A (en) 1991-09-05 1992-08-18 Crystalline form of R (- 3 - methoxy - - 4 -] 1 - mill - 5 -) 2 - methyl - 4, 4, 4 - trifluorobutylcarbamoil (indole - 3 - ylmethyl [- N -) 2 - methylphenyl -

Country Status (21)

Country Link
US (2) US5352694A (zh)
EP (1) EP0531078B1 (zh)
JP (1) JP2914414B2 (zh)
KR (1) KR100254710B1 (zh)
AT (1) ATE138910T1 (zh)
AU (1) AU646587B2 (zh)
CA (1) CA2076722A1 (zh)
CZ (1) CZ281999B6 (zh)
DE (1) DE69211258T2 (zh)
DK (1) DK0531078T3 (zh)
FI (1) FI102372B (zh)
GB (2) GB9119001D0 (zh)
HK (1) HK18297A (zh)
HU (2) HU213410B (zh)
IL (1) IL102856A (zh)
NO (1) NO178370C (zh)
NZ (1) NZ244016A (zh)
RU (1) RU2095348C1 (zh)
SK (1) SK267092A3 (zh)
TW (1) TW302359B (zh)
ZA (1) ZA926374B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958780A (en) 1997-06-30 1999-09-28 Boston Advanced Technologies, Inc. Method for marking and identifying liquids
US6149914A (en) * 1999-07-12 2000-11-21 Patel; Jitendra Rambhai Asthma treatment
TWI353979B (en) * 2002-04-10 2011-12-11 Nippon Zoki Pharmaceutical Co Novel crystal form of 5-hydroxy-1-methylhydantoin
US20080206203A1 (en) 2004-07-14 2008-08-28 Inflammation Research Center Company Ltd. Method for Inhibiting Tumor Metastasis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524152A (en) * 1982-12-30 1985-06-18 Pennwalt Corporation 1-Cyano-3-(fluoroalkyl)guanidines for lowering blood pressure
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8906032D0 (en) * 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9026425D0 (en) * 1990-12-05 1991-01-23 Ici Plc Process
GB9027018D0 (en) * 1990-12-12 1991-01-30 Ici Plc Heterocyclic compounds
IL100091A (en) * 1990-12-12 1998-08-16 Zeneca Ltd Pharmaceutical preparations containing the physical form of [4] 5) Cyclopentyloxycarbyl (amino 1 methyl indole 3 methyl methyl [3 methoxybenzoyl [2 methylbenzole)

Also Published As

Publication number Publication date
NO923467D0 (no) 1992-09-04
DK0531078T3 (da) 1996-10-14
JP2914414B2 (ja) 1999-06-28
HK18297A (en) 1997-02-13
NZ244016A (en) 1995-01-27
JPH05194385A (ja) 1993-08-03
TW302359B (zh) 1997-04-11
AU2101292A (en) 1993-03-11
DE69211258T2 (de) 1996-10-02
KR100254710B1 (ko) 2000-05-01
EP0531078B1 (en) 1996-06-05
DE69211258D1 (de) 1996-07-11
FI102372B1 (fi) 1998-11-30
ATE138910T1 (de) 1996-06-15
CA2076722A1 (en) 1993-03-06
US5352694A (en) 1994-10-04
AU646587B2 (en) 1994-02-24
EP0531078A1 (en) 1993-03-10
NO178370B (no) 1995-12-04
NO923467L (no) 1993-03-08
GB9216774D0 (en) 1992-09-23
FI102372B (fi) 1998-11-30
FI923869A0 (fi) 1992-08-28
SK279657B6 (sk) 1999-02-11
HU210879A9 (en) 1995-09-28
HU9202660D0 (en) 1992-10-28
IL102856A0 (en) 1993-01-31
KR930005976A (ko) 1993-04-20
ZA926374B (en) 1993-03-05
CZ281999B6 (cs) 1997-04-16
RU2095348C1 (ru) 1997-11-10
NO178370C (no) 1996-03-13
HUT69696A (en) 1995-09-28
US5466826A (en) 1995-11-14
FI923869A (fi) 1993-03-06
HU213410B (en) 1997-06-30
SK267092A3 (en) 1999-02-11
GB9119001D0 (en) 1991-10-23
CZ267092A3 (en) 1993-03-17

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MM9K Patent not in force due to non-payment of renewal fees