IL102645A - Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them - Google Patents

Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them

Info

Publication number
IL102645A
IL102645A IL102645A IL10264592A IL102645A IL 102645 A IL102645 A IL 102645A IL 102645 A IL102645 A IL 102645A IL 10264592 A IL10264592 A IL 10264592A IL 102645 A IL102645 A IL 102645A
Authority
IL
Israel
Prior art keywords
compound
ome
process according
residue
group
Prior art date
Application number
IL102645A
Other languages
English (en)
Other versions
IL102645A0 (en
Inventor
Avigdor Scherz
Yoram Salomon
Leszek Fiedor
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL102645A priority Critical patent/IL102645A/en
Publication of IL102645A0 publication Critical patent/IL102645A0/xx
Priority to ZA935310A priority patent/ZA935310B/xx
Priority to AU42148/93A priority patent/AU674315B2/en
Priority to CA002101227A priority patent/CA2101227C/en
Priority to HU9302149A priority patent/HU221186B1/hu
Priority to ES93111942T priority patent/ES2153367T3/es
Priority to PL93319910A priority patent/PL173128B1/pl
Priority to CN93116862A priority patent/CN1040212C/zh
Priority to AT93111942T priority patent/ATE196850T1/de
Priority to PT93111942T priority patent/PT584552E/pt
Priority to DK93111942T priority patent/DK0584552T3/da
Priority to PL93299803A priority patent/PL173150B1/pl
Priority to EP93111942A priority patent/EP0584552B1/de
Priority to US08/097,384 priority patent/US5726169A/en
Priority to DE69329538T priority patent/DE69329538T2/de
Priority to JP22632893A priority patent/JP3612343B2/ja
Priority to US08/461,243 priority patent/US5955585A/en
Priority to US08/463,950 priority patent/US5650292A/en
Publication of IL102645A publication Critical patent/IL102645A/en
Priority to GR20010400013T priority patent/GR3035195T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
IL102645A 1992-07-26 1992-07-26 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them IL102645A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IL102645A IL102645A (en) 1992-07-26 1992-07-26 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
ZA935310A ZA935310B (en) 1992-07-26 1993-07-22 Chlorophyll and bacteriochlorophyll derivatives and pharmaceutical compositions comprising them
AU42148/93A AU674315B2 (en) 1992-07-26 1993-07-22 Chlorophyll and bacteriochlorophyll derivatives and pharmaceutical compositions containing them
CA002101227A CA2101227C (en) 1992-07-26 1993-07-23 Chlorophyll and bacteriochlorophyll derivatives and pharmaceutical compositions containing them
HU9302149A HU221186B1 (en) 1992-07-26 1993-07-23 Chlorophyll and bacterio chlorophyll derivatives, method for producing them and diagnostic and pharmaceutical compositions comprising thereof
JP22632893A JP3612343B2 (ja) 1992-07-26 1993-07-26 クロロフィルとバクテリオクロロフィルの誘導体、それらの製造法及びそれら誘導体を含んで成る製剤組成物
AT93111942T ATE196850T1 (de) 1992-07-26 1993-07-26 Chlorophyll- und bakteriochlorophyll-derivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
EP93111942A EP0584552B1 (de) 1992-07-26 1993-07-26 Chlorophyll- und Bakteriochlorophyll-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
CN93116862A CN1040212C (zh) 1992-07-26 1993-07-26 叶绿素、细菌叶绿素衍生物,它们的制备以及含有它们的药物组合物
ES93111942T ES2153367T3 (es) 1992-07-26 1993-07-26 Derivados de clorofila y de bacterioclorofila, su preparacion y composiciones farmaceuticas que los contienen.
PT93111942T PT584552E (pt) 1992-07-26 1993-07-26 Derivados da clorofila e da bacterioclorofila a sua preparacao e composicoes farmaceuticas que os incluem
DK93111942T DK0584552T3 (da) 1992-07-26 1993-07-26 Chlorophyl- og bakteriochlorophylderivater, deres fremstilling og farmaceutiske sammensætninger omfattende dem
PL93299803A PL173150B1 (pl) 1992-07-26 1993-07-26 Nowe pochodne chlorofilu i bakteriofilu oraz sposób otrzymywania tych pochodnych
PL93319910A PL173128B1 (pl) 1992-07-26 1993-07-26 Sposób wytwarzania nowych pochodnych chlorofilu i bakteriochlorofilu
US08/097,384 US5726169A (en) 1992-07-26 1993-07-26 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
DE69329538T DE69329538T2 (de) 1992-07-26 1993-07-26 Chlorophyll- und Bakteriochlorophyll-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
US08/461,243 US5955585A (en) 1992-07-26 1995-06-05 Catalytic condensation method for the preparation of chlorophyll and bacteriochlorophyll derivatives
US08/463,950 US5650292A (en) 1992-07-26 1995-07-31 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
GR20010400013T GR3035195T3 (en) 1992-07-26 2001-01-10 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL102645A IL102645A (en) 1992-07-26 1992-07-26 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them

Publications (2)

Publication Number Publication Date
IL102645A0 IL102645A0 (en) 1993-01-14
IL102645A true IL102645A (en) 1998-02-22

Family

ID=11063865

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102645A IL102645A (en) 1992-07-26 1992-07-26 Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them

Country Status (16)

Country Link
US (3) US5726169A (de)
EP (1) EP0584552B1 (de)
JP (1) JP3612343B2 (de)
CN (1) CN1040212C (de)
AT (1) ATE196850T1 (de)
AU (1) AU674315B2 (de)
CA (1) CA2101227C (de)
DE (1) DE69329538T2 (de)
DK (1) DK0584552T3 (de)
ES (1) ES2153367T3 (de)
GR (1) GR3035195T3 (de)
HU (1) HU221186B1 (de)
IL (1) IL102645A (de)
PL (2) PL173128B1 (de)
PT (1) PT584552E (de)
ZA (1) ZA935310B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045492A2 (en) 2002-11-17 2004-06-03 Yeda Research And Development Co. Ltd. Water-soluble anionic bacteriochlorophyll derivatives and their uses

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DE69934328T2 (de) * 1998-12-09 2007-07-19 Yeda Research And Development Co., Ltd. Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung
US7045117B2 (en) * 1999-12-01 2006-05-16 Yeda Research And Development Co. Ltd. Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
IL133253A0 (en) * 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
JP2003519670A (ja) * 2000-01-12 2003-06-24 ライト サイエンシーズ コーポレイション 眼疾患の新規処置
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US20020169107A1 (en) * 2001-01-19 2002-11-14 Mallinckrodt Inc. Novel aromatic azides for type I phototherapy
AU7570201A (en) * 2000-07-26 2002-02-05 Riley Patrick Anthony Phenylethylamine derivatives and their use in the treatment of melanoma
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AU2006200164B2 (en) * 2001-04-09 2007-03-08 Oncofluor, Inc. Method for viewing tumor tissue located within a body cavity
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
BR0304716A (pt) 2002-05-08 2004-07-13 Yeda Res & Dev Método para formação de imagens de mri-bold on line, sensibilizada
GB0323358D0 (en) * 2003-10-06 2003-11-05 Green Grass Design Ltd Novel compounds and processes
ES2602460T3 (es) 2004-06-07 2017-02-21 Yeda Research And Development Co., Ltd. Derivados de bacterioclorofila catiónicos y usos de los mismos
US7947827B2 (en) * 2006-06-30 2011-05-24 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Pharmaceutical formulation comprising a metaloporphyrin and method for its purification and use
US9957293B2 (en) 2006-08-23 2018-05-01 Yeda Research And Development Company Ltd. Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses
CA2661319C (en) * 2006-08-23 2015-12-01 Yeda Research And Development Co. Ltd Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses
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DK2257309T3 (da) 2008-02-27 2020-01-20 Yeda Res And Development Company Ltd Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner
RU2632439C2 (ru) 2011-08-23 2017-10-04 Йеда Рисерч Энд Дивелопмент Ко., Лтд. Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств
CN105072981B (zh) * 2012-12-19 2017-10-24 纽约州立大学研究基金会 用于激光诱导纳米微球释放内含物的组合物和方法
BR112015030233A2 (pt) * 2013-06-05 2017-07-25 Hafezi Farhad método de aplicação de uma composição e composição farmacêutica com um regime de administração da mesma
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RU2536109C1 (ru) * 2013-07-25 2014-12-20 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ комбинированной обработки склерального ложа после эндорезекции внутриглазного новообразования
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CN111171030B (zh) * 2018-11-12 2022-11-22 浙江海正药业股份有限公司 细菌叶绿素衍生物及其制备方法
CN115093422B (zh) * 2022-06-15 2023-06-20 西北工业大学 一种基于代谢标记策略的新型光敏剂及其制备方法和应用
CN116585530B (zh) * 2023-05-05 2024-02-02 暨南大学 一种高效产氧的叶绿体复合水凝胶及其制备方法与应用

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US5330741A (en) * 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045492A2 (en) 2002-11-17 2004-06-03 Yeda Research And Development Co. Ltd. Water-soluble anionic bacteriochlorophyll derivatives and their uses
EP2522349A1 (de) 2002-11-17 2012-11-14 Yeda Research and Development Co. Ltd. Wasserlösliche anionische Bakteriochlorophyl-Derivate und ihre Verwendungen

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IL102645A0 (en) 1993-01-14
ATE196850T1 (de) 2000-10-15
PL173128B1 (pl) 1998-01-30
US5726169A (en) 1998-03-10
PT584552E (pt) 2001-04-30
PL173150B1 (pl) 1998-01-30
EP0584552A2 (de) 1994-03-02
GR3035195T3 (en) 2001-04-30
DE69329538D1 (de) 2000-11-16
CA2101227A1 (en) 1994-01-27
DE69329538T2 (de) 2001-06-07
JP3612343B2 (ja) 2005-01-19
HU221186B1 (en) 2002-08-28
HU9302149D0 (en) 1993-10-28
JPH0733772A (ja) 1995-02-03
AU674315B2 (en) 1996-12-19
EP0584552B1 (de) 2000-10-11
DK0584552T3 (da) 2001-02-05
CN1040212C (zh) 1998-10-14
EP0584552A3 (en) 1994-08-17
US5650292A (en) 1997-07-22
ZA935310B (en) 1994-02-11
HUT64949A (en) 1994-03-28
CA2101227C (en) 2002-11-12
ES2153367T3 (es) 2001-03-01
AU4214893A (en) 1994-01-27
CN1088210A (zh) 1994-06-22
US5955585A (en) 1999-09-21
PL299803A1 (en) 1994-02-07

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