IL101883A - Antiviral compounds comprising 4 amino acids 1) 2-hydroxy methyl 1,3 oxathiolene 5 ul (H1 pyrimidine 2 on and inhibitor of VIH transcription and pharmaceutical preparations including them - Google Patents
Antiviral compounds comprising 4 amino acids 1) 2-hydroxy methyl 1,3 oxathiolene 5 ul (H1 pyrimidine 2 on and inhibitor of VIH transcription and pharmaceutical preparations including themInfo
- Publication number
- IL101883A IL101883A IL10188392A IL10188392A IL101883A IL 101883 A IL101883 A IL 101883A IL 10188392 A IL10188392 A IL 10188392A IL 10188392 A IL10188392 A IL 10188392A IL 101883 A IL101883 A IL 101883A
- Authority
- IL
- Israel
- Prior art keywords
- inhibitor
- combination
- oxathiolan
- pyrimidin
- hiv replication
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims abstract description 21
- 230000010076 replication Effects 0.000 title claims abstract description 18
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 230000000840 anti-viral effect Effects 0.000 title description 12
- JTEGQNOMFQHVDC-UHFFFAOYSA-N 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1C1OC(CO)SC1 JTEGQNOMFQHVDC-UHFFFAOYSA-N 0.000 title 1
- 238000011282 treatment Methods 0.000 claims abstract description 6
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- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims description 5
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims description 5
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- QWXYZCJEXYQNEI-OSZHWHEXSA-N intermediate I Chemical compound COC(=O)[C@@]1(C=O)[C@H]2CC=[N+](C\C2=C\C)CCc2c1[nH]c1ccccc21 QWXYZCJEXYQNEI-OSZHWHEXSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919110624A GB9110624D0 (en) | 1991-05-16 | 1991-05-16 | Combinations |
| GB919121381A GB9121381D0 (en) | 1991-10-08 | 1991-10-08 | Combinations |
| GB919123581A GB9123581D0 (en) | 1991-11-06 | 1991-11-06 | Combinations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL101883A0 IL101883A0 (en) | 1992-12-30 |
| IL101883A true IL101883A (en) | 1998-10-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| IL10188392A IL101883A (en) | 1991-05-16 | 1992-05-15 | Antiviral compounds comprising 4 amino acids 1) 2-hydroxy methyl 1,3 oxathiolene 5 ul (H1 pyrimidine 2 on and inhibitor of VIH transcription and pharmaceutical preparations including them |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US5627186A (fr) |
| EP (1) | EP0513917B2 (fr) |
| JP (1) | JP2868671B2 (fr) |
| KR (1) | KR100246687B1 (fr) |
| CN (1) | CN1045961C (fr) |
| AT (1) | ATE131730T1 (fr) |
| AU (2) | AU1787492A (fr) |
| CA (1) | CA2068790C (fr) |
| CZ (1) | CZ285232B6 (fr) |
| DE (2) | DE19875016I2 (fr) |
| DK (1) | DK0513917T4 (fr) |
| ES (1) | ES2083668T5 (fr) |
| GR (1) | GR3018915T3 (fr) |
| HK (1) | HK78897A (fr) |
| IE (1) | IE73261B1 (fr) |
| IL (1) | IL101883A (fr) |
| LU (1) | LU90234I2 (fr) |
| MX (1) | MX9202279A (fr) |
| NL (1) | NL980018I2 (fr) |
| NO (2) | NO301690B1 (fr) |
| NZ (2) | NZ299240A (fr) |
| OA (1) | OA10058A (fr) |
| SK (1) | SK279262B6 (fr) |
| TW (1) | TW273550B (fr) |
| WO (1) | WO1992020344A1 (fr) |
Families Citing this family (31)
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| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
| US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
| US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
| ES2138624T3 (es) * | 1992-05-13 | 2000-01-16 | Wellcome Found | Combinaciones terapeuticas. |
| GB9215178D0 (en) * | 1992-07-16 | 1992-08-26 | Glaxo Group Ltd | Antiviral combinations |
| IL113432A (en) | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
| FR2720397B1 (fr) * | 1994-05-24 | 1996-08-23 | Laphal Laboratoires Sa | Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. |
| TW401303B (en) * | 1994-07-01 | 2000-08-11 | Janssen Pharmaceutica Nv | Anti-HIV triple combination |
| GB9503850D0 (en) * | 1995-02-25 | 1995-04-19 | Glaxo Group Ltd | Medicaments |
| MY115461A (en) | 1995-03-30 | 2003-06-30 | Wellcome Found | Synergistic combinations of zidovudine, 1592u89 and 3tc |
| WO1997049411A1 (fr) | 1996-06-25 | 1997-12-31 | Glaxo Group Limited | Combinaisons comprenant du vx478, de la zidovudine, du ftc et/ou 3tc pouvant etre utilisees dans le traitement du vih |
| GB9622681D0 (en) * | 1996-10-31 | 1997-01-08 | Glaxo Group Ltd | Pharmaceutical compositions |
| US6113920A (en) * | 1996-10-31 | 2000-09-05 | Glaxo Wellcome Inc. | Pharmaceutical compositions |
| TW536403B (en) * | 1997-03-24 | 2003-06-11 | Glaxo Group Ltd | An ethanol and ethylenediaminetetraacetic acid free pharmaceutical composition comprising lamivudine and exhibiting antimicrobial preservative efficacy |
| DE69840216D1 (de) | 1997-08-08 | 2008-12-24 | Celmed Oncology Usa Inc | Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden |
| TWI244924B (en) | 1998-01-23 | 2005-12-11 | Newbiotics Inc | Enzyme catalyzed therapeutic agents |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| BR9911457A (pt) * | 1998-06-24 | 2001-12-11 | Univ Emory | Uso de 3'-azida-2', 3'-dideoxiuridina em combinaçãocom drogas anti-hiv adicionais para a manufaturade um medicamento para o tratamento de hiv |
| IL147749A0 (en) | 1999-07-22 | 2002-08-14 | Newbiotics Inc | Methods for treating therapy-resistant tumors |
| US6432966B2 (en) | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
| AP2220A (en) * | 2001-05-11 | 2011-03-24 | Cipla Medpro Pty Ltd | Pharmaceutical composition. |
| DE60313657T2 (de) * | 2002-11-08 | 2008-01-03 | Smithkline Beecham Corp. | Antivirale zusammensetzungen |
| AU2004206827A1 (en) | 2003-01-14 | 2004-08-05 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
| JP4482883B2 (ja) | 2003-05-22 | 2010-06-16 | リードケミカル株式会社 | 抗ウイルス作用を有する化合物およびその配合剤 |
| TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| EP1975923B1 (fr) * | 2007-03-28 | 2016-04-27 | Nuance Communications, Inc. | Reconnaissance vocale non-native plurilingues |
| WO2010137027A1 (fr) | 2009-05-27 | 2010-12-02 | Hetero Research Foundation | Formes pharmaceutiques solides de lamivudine s'administrant par voie orale |
| WO2011156594A2 (fr) | 2010-06-09 | 2011-12-15 | Vaccine Technologies, Incorporated | Immunisation thérapeutique chez des patients infectés par le vih recevant un traitement antirétroviral stable |
| CN104203244A (zh) | 2012-03-05 | 2014-12-10 | 希普拉有限公司 | 包含拉米夫定、festinnvir和奈韦拉平的抗反转录病毒药物组合物 |
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| IT1214611B (it) * | 1985-05-22 | 1990-01-18 | Schiena Ricerche | Composti per uso cosmetico dermatologico e relative composizioni. |
| GB8717955D0 (en) * | 1987-07-29 | 1987-09-03 | Fujisawa Pharmaceutical Co | Prevention & treatment of aids |
| US5270464A (en) * | 1989-03-14 | 1993-12-14 | Janssen Pharmaceutica N.V. | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones |
| JPH02504283A (ja) * | 1988-03-23 | 1990-12-06 | ニューヨーク ユニバーシィティ | 芳香族多環式ジオン化合物とヌクレオシド類似化合物とを含む抗ウイルス性組成物及びレトロウイルス感染を治療するための方法 |
| WO1989009056A1 (fr) * | 1988-03-23 | 1989-10-05 | New York University | Composition antivirale contenant des diones aromatiques polycycliques et des analogues de nucleosides, et procede de traitement d'infections retrovirales |
| US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
| ES2038847T3 (es) * | 1988-09-28 | 1993-08-01 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Proceso para la preparacion de una composicion farmacutica conteniendo zidovudine e inosiplex para el tratamiento del sida y sindromes afines. |
| DE58902899D1 (de) * | 1988-12-14 | 1993-01-14 | Ciba Geigy Ag | 2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor kombinationstherapie und zusammensetzungen dafuer. |
| US5132291A (en) * | 1989-01-24 | 1992-07-21 | Gensia Pharmaceuticals, Inc. | Antivirals and methods for increasing the antiviral activity of azt |
| IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them |
| NZ232912A (en) * | 1989-03-17 | 1992-06-25 | Oncogen Ltd Lp | Synergistic composition of nucleoside derivatives for inhibiting hiv |
| US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
| SE464168B (sv) † | 1989-07-19 | 1991-03-18 | Bo Fredrik Oeberg | Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt) |
| US5116823A (en) * | 1990-02-27 | 1992-05-26 | Roger Williams General Hospital | Drug combinations containing AZT |
| GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
-
1992
- 1992-05-11 WO PCT/EP1992/001106 patent/WO1992020344A1/fr active IP Right Grant
- 1992-05-11 ES ES92201328T patent/ES2083668T5/es not_active Expired - Lifetime
- 1992-05-11 DK DK92201328T patent/DK0513917T4/da active
- 1992-05-11 DE DE1998175016 patent/DE19875016I2/de active Active
- 1992-05-11 AU AU17874/92A patent/AU1787492A/en not_active Abandoned
- 1992-05-11 DE DE69206876T patent/DE69206876T3/de not_active Expired - Lifetime
- 1992-05-11 AT AT92201328T patent/ATE131730T1/de active
- 1992-05-11 EP EP92201328A patent/EP0513917B2/fr not_active Expired - Lifetime
- 1992-05-11 CZ CZ932428A patent/CZ285232B6/cs not_active IP Right Cessation
- 1992-05-11 SK SK1199-93A patent/SK279262B6/sk not_active IP Right Cessation
- 1992-05-15 JP JP4148384A patent/JP2868671B2/ja not_active Expired - Lifetime
- 1992-05-15 CA CA002068790A patent/CA2068790C/fr not_active Expired - Lifetime
- 1992-05-15 MX MX9202279A patent/MX9202279A/es not_active IP Right Cessation
- 1992-05-15 KR KR1019920008239A patent/KR100246687B1/ko not_active IP Right Cessation
- 1992-05-15 AU AU16279/92A patent/AU661307B2/en not_active Expired
- 1992-05-15 TW TW081103780A patent/TW273550B/zh not_active IP Right Cessation
- 1992-05-15 NZ NZ299240A patent/NZ299240A/en not_active IP Right Cessation
- 1992-05-15 CN CN92104553A patent/CN1045961C/zh not_active Expired - Lifetime
- 1992-05-15 NZ NZ242754A patent/NZ242754A/en not_active IP Right Cessation
- 1992-05-15 IL IL10188392A patent/IL101883A/en not_active IP Right Cessation
- 1992-05-15 NO NO921947A patent/NO301690B1/no not_active IP Right Cessation
- 1992-07-01 IE IE921566A patent/IE73261B1/en not_active IP Right Cessation
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1993
- 1993-10-22 OA OA60427A patent/OA10058A/en unknown
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1994
- 1994-03-28 US US08/219,176 patent/US5627186A/en not_active Expired - Lifetime
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1996
- 1996-02-07 GR GR960400321T patent/GR3018915T3/el unknown
- 1996-02-22 US US08/605,610 patent/US5859021A/en not_active Expired - Lifetime
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1997
- 1997-06-12 HK HK78897A patent/HK78897A/xx not_active IP Right Cessation
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1998
- 1998-04-24 LU LU90234C patent/LU90234I2/fr unknown
- 1998-04-28 NL NL980018C patent/NL980018I2/nl unknown
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1999
- 1999-07-22 NO NO1999018C patent/NO1999018I1/no unknown
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