IL101373A - Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them - Google Patents

Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them

Info

Publication number
IL101373A
IL101373A IL10137392A IL10137392A IL101373A IL 101373 A IL101373 A IL 101373A IL 10137392 A IL10137392 A IL 10137392A IL 10137392 A IL10137392 A IL 10137392A IL 101373 A IL101373 A IL 101373A
Authority
IL
Israel
Prior art keywords
aza
decal
dimethyl
compound
formula
Prior art date
Application number
IL10137392A
Other languages
English (en)
Hebrew (he)
Other versions
IL101373A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL101373A0 publication Critical patent/IL101373A0/xx
Publication of IL101373A publication Critical patent/IL101373A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10137392A 1991-03-27 1992-03-25 Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them IL101373A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/676,149 US5084461A (en) 1991-03-27 1991-03-27 Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis

Publications (2)

Publication Number Publication Date
IL101373A0 IL101373A0 (en) 1992-11-15
IL101373A true IL101373A (en) 1996-10-16

Family

ID=24713429

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10137392A IL101373A (en) 1991-03-27 1992-03-25 Azadeclin Amides and thioamides and cholesterol biosynthetic inhibitors containing them

Country Status (18)

Country Link
US (2) US5084461A (fi)
EP (1) EP0506072B1 (fi)
JP (1) JP3172975B2 (fi)
KR (1) KR100224046B1 (fi)
AT (1) ATE153021T1 (fi)
AU (1) AU641089B2 (fi)
CA (1) CA2063938C (fi)
DE (1) DE69219660T2 (fi)
DK (1) DK0506072T3 (fi)
ES (1) ES2103847T3 (fi)
FI (1) FI102373B (fi)
GR (1) GR3024367T3 (fi)
HU (1) HUT66656A (fi)
IE (1) IE920969A1 (fi)
IL (1) IL101373A (fi)
NO (1) NO178301C (fi)
NZ (1) NZ242108A (fi)
ZA (1) ZA922107B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5348964A (en) * 1990-07-25 1994-09-20 Merrell Dow Pharmaceuticals Inc. Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US5350758A (en) * 1992-07-08 1994-09-27 Merrell Dow Pharmaceuticals Inc. Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
DE4303840A1 (de) * 1992-10-22 1994-08-11 Thomae Gmbh Dr K Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US5466687A (en) * 1992-10-22 1995-11-14 Dr. Karl Thomae Gmbh Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation
FR2697252B1 (fr) * 1992-10-28 1994-12-09 Fournier Ind & Sante Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique.
DE19754795A1 (de) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200831497A (en) * 2006-10-12 2008-08-01 Epix Delaware Inc Carboxamide compounds and their use
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
JP2011506466A (ja) 2007-12-11 2011-03-03 株式会社サイトパスファインダー カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク ２−フェニルベンゾイルアミド
WO2012120414A2 (en) 2011-03-04 2012-09-13 Pfizer Inc. Edn3-like peptides and uses thereof
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3911648A4 (en) 2019-01-18 2022-10-26 Astrazeneca AB PCSK9 INHIBITORS AND METHODS OF USE THEREOF
CN111334460A (zh) * 2020-03-30 2020-06-26 江苏师范大学 一种抑制黄曲霉温度耐受性的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
US5084461A (en) * 1991-03-27 1992-01-28 Merrell Dow Pharmaceuticals Inc. Azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase

Also Published As

Publication number Publication date
US5278171A (en) 1994-01-11
DE69219660T2 (de) 1997-09-11
NO178301C (no) 1996-02-28
DE69219660D1 (de) 1997-06-19
CA2063938A1 (en) 1992-09-28
FI921327A (fi) 1992-09-28
ES2103847T3 (es) 1997-10-01
DK0506072T3 (fi) 1997-06-09
KR920018028A (ko) 1992-10-21
JP3172975B2 (ja) 2001-06-04
NO178301B (no) 1995-11-20
FI921327A0 (fi) 1992-03-26
HU9200944D0 (en) 1992-05-28
FI102373B1 (fi) 1998-11-30
EP0506072A1 (en) 1992-09-30
HUT66656A (en) 1994-12-28
AU641089B2 (en) 1993-09-09
IE920969A1 (en) 1992-10-07
ATE153021T1 (de) 1997-05-15
ZA922107B (en) 1992-11-25
GR3024367T3 (en) 1997-11-28
AU1309092A (en) 1992-10-01
NO921187L (no) 1992-09-28
IL101373A0 (en) 1992-11-15
KR100224046B1 (ko) 1999-10-15
JPH05140112A (ja) 1993-06-08
US5084461A (en) 1992-01-28
NO921187D0 (no) 1992-03-26
NZ242108A (en) 1993-09-27
FI102373B (fi) 1998-11-30
CA2063938C (en) 2002-08-13
EP0506072B1 (en) 1997-05-14

Similar Documents

Publication Publication Date Title
EP0506072B1 (en) Novel azadecalin amides and thioamides as inhibitors of cholesterol biosynthesis
US4632934A (en) Imidazole derivatives and pharmaceutical use thereof
JP3387513B2 (ja) ピペリジルエーテル類及びチオエーテル類を含むコレステロール生合成の抑制剤及び菌類感染症治療剤
US4381398A (en) Amino-alcohol derivatives
US5011859A (en) Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase
US5350758A (en) Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
EP0069513A2 (en) Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
KR850000627B1 (ko) 시클로헥센 유도체의 제조방법
US5064864A (en) Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase
EP0007441B1 (en) N - (n-acetyl-l-methionyl) - 3,4 -diethoxy-carbonyloxy-phenethylamine, process for preparing same and a pharmaceutical composition containing said compound.
EP0816338A1 (en) 3-(bis-substituted-phenylmethylene)oxindole derivatives
EP0563798A1 (en) Butadiene derivatives, their preparation and use as an antithrombotic agent
EP0157623B1 (en) Optically active isomers of benzopyran derivatives useful for treating cardiovascular disease
JPH03130262A (ja) 新規の置換アルキルピペリジンとコレステロール合成阻害剤としてのその用途
US5348964A (en) Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
US4980362A (en) 4-substituted-2-alkoxytetrahydrofuran derivatives
EP0219468B1 (en) 4-methoxy-isophthalic acid derivative having a pharmacological activity in thromboembolic disorders and a process for the preparation thereof
JPH0789898A (ja) ビフェニル誘導体
JP4160650B2 (ja) オルト置換されたベンゾイルグアニジン、その製造法、医薬または診断剤としてのその使用およびそれを含む医薬
US5157166A (en) Process for the preparation of di-fluro analogs of squalene
JPS6215547B2 (fi)
JPH07233128A (ja) ジベンジルアミン誘導体
JPH02311479A (ja) キノリン誘導体

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees