IL100572A - Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them - Google Patents

Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them

Info

Publication number
IL100572A
IL100572A IL10057292A IL10057292A IL100572A IL 100572 A IL100572 A IL 100572A IL 10057292 A IL10057292 A IL 10057292A IL 10057292 A IL10057292 A IL 10057292A IL 100572 A IL100572 A IL 100572A
Authority
IL
Israel
Prior art keywords
antibiotic
amides
factors
preparation
pharmaceutical compositions
Prior art date
Application number
IL10057292A
Other languages
English (en)
Other versions
IL100572A0 (en
Inventor
Paolo Tavecchia
Sergio Lociuro
Romeo Ciabatti
Enrico Selva
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Publication of IL100572A0 publication Critical patent/IL100572A0/xx
Publication of IL100572A publication Critical patent/IL100572A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
IL10057292A 1991-01-03 1992-01-01 Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them IL100572A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91100123 1991-01-03

Publications (2)

Publication Number Publication Date
IL100572A0 IL100572A0 (en) 1992-09-06
IL100572A true IL100572A (en) 1997-01-10

Family

ID=8206281

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10057292A IL100572A (en) 1991-01-03 1992-01-01 Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
US (1) US5599791A (fr)
EP (2) EP0494078A1 (fr)
JP (1) JP3183508B2 (fr)
KR (1) KR100225763B1 (fr)
CN (1) CN1063110A (fr)
AT (1) ATE117320T1 (fr)
AU (1) AU662122B2 (fr)
CA (1) CA2093219C (fr)
DE (1) DE69201236T2 (fr)
ES (1) ES2067325T3 (fr)
FI (1) FI932944A (fr)
HU (1) HU224072B1 (fr)
IE (1) IE920005A1 (fr)
IL (1) IL100572A (fr)
MX (1) MX9200015A (fr)
NZ (1) NZ241216A (fr)
WO (1) WO1992012172A1 (fr)
ZA (1) ZA927B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0451486T3 (da) * 1990-03-08 1995-05-08 Lepetit Spa Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
ES2113391T3 (es) * 1991-08-30 1998-05-01 Biosearch Italia Spa Factor c2a de antibiotico ge 2270.
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
EP0675900B1 (fr) * 1992-12-22 1998-02-18 Biosearch Italia S.p.A. Antiobiotiques ge 37468 a, b et c
ATE165101T1 (de) * 1995-02-07 1998-05-15 Biosearch Italia Spa Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika
US5891869A (en) * 1995-02-07 1999-04-06 Biosearch Italia, S.P.A. Basic oxazoline-amide derivatives of GE2270 and GE2270-like antibiotics
IL125107A (en) * 1996-02-14 2002-12-01 Biosearch Italia Spa Derivatives of antibiotics GE2270 factors D2, C2a and E, process for their preparation and pharmaceutical compounds containing them
JPH1059997A (ja) * 1996-08-22 1998-03-03 Microbial Chem Res Found アミチアマイシンアミド誘導体
US20050166498A1 (en) * 1999-12-17 2005-08-04 Oakey David D. Carpet tile with cutout section, method and apparatus for production and method of installation
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
PT1553967E (pt) * 2002-06-17 2011-08-01 Naicons S C A R L Utilização de um derivado amídico do factor a3 do ge 2270 no tratamento da acne
DE602004014361D1 (de) 2003-04-30 2008-07-24 Morphochem Ag Komb Chemie Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen
JP2007516263A (ja) 2003-12-18 2007-06-21 モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー オキサゾリジノン−キノロンハイブリッド抗生物質
ATE455181T1 (de) * 2004-01-19 2010-01-15 Dsm Ip Assets Bv Biochemische synthese von 6-aminocapronsäure
PE20080103A1 (es) * 2006-05-31 2008-04-03 Novartis Ag AMINOTIAZOLES COMO MODULADORES DEL FACTOR DE ELONGACION EF-Tu
KR20090082504A (ko) * 2006-12-20 2009-07-30 노파르티스 아게 아미노티아졸 마크로사이클, 그의 항균 화합물로서의 용도 및 그의 제조 방법
WO2008091627A2 (fr) 2007-01-22 2008-07-31 Genomatica, Inc. Procédés et organismes pour la production couplée à la croissance de l'acide 3-hydroxypropionique
EA200901613A1 (ru) 2007-06-04 2010-06-30 Новартис Аг Макроциклы и их применение
WO2009045637A2 (fr) 2007-08-10 2009-04-09 Genomatica, Inc. Procédés de synthèse d'oléfines et de dérivés
EA020205B1 (ru) 2007-12-12 2014-09-30 Новартис Аг Аминотиазолы, фармацевтические композиции на их основе и способы лечения бактериальной инфекции
CA2712779C (fr) 2008-01-22 2021-03-16 Genomatica, Inc. Methodes et organismes destines a l'utilisation de gaz de synthese ou d'autres sources gazeuses de carbone et de methanol
BRPI0909690A2 (pt) 2008-03-05 2019-02-26 Genomatica Inc organismos produtores de alcoóis primários
WO2009151728A2 (fr) 2008-03-27 2009-12-17 Genomatica, Inc. Microorganismes pour la production d'acide adipique et autres composés
BRPI0911759A2 (pt) 2008-05-01 2019-09-24 Genomatica Inc microorganismo para a produção de ácido metacrílico
BRPI0913901A2 (pt) 2008-06-17 2016-12-13 Genomatica Inc micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
JP2012525156A (ja) 2009-04-30 2012-10-22 ゲノマチカ， インク． イソプロパノール、ｎ−ブタノール、及びイソブタノールの産生のための微生物
KR102454204B1 (ko) 2009-04-30 2022-10-12 게노마티카 인코포레이티드 1,3-부탄다이올 생산 유기체
US8377680B2 (en) 2009-05-07 2013-02-19 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
BRPI1012877A2 (pt) 2009-05-15 2016-04-05 Genomatica Inc organismo para produção de ciclohexanona
WO2010144746A2 (fr) 2009-06-10 2010-12-16 Genomatica, Inc. Microorganismes et procédés pour la biosynthèse à bon bilan carbone de mek et de 2-butanol
EP2462221B1 (fr) 2009-08-05 2017-02-22 Genomatica, Inc. Acide téréphtalique semi-synthétique obtenu par l'intermédiaire de micro-organismes qui produisent de l'acide muconique
EP2933338A3 (fr) 2009-09-09 2016-01-06 Genomatica, Inc. Micro-organismes et procédés pour la coproduction d'isopropanol avec des alcools primaires, des diols et des acides
KR20120083908A (ko) 2009-10-13 2012-07-26 게노마티카 인코포레이티드 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-ｃｏａ, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법
BR112012009332A2 (pt) 2009-10-23 2015-09-15 Genomatica Inc micro-organismo para a produção de anilina
CN109136161A (zh) 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
CA2787314A1 (fr) 2010-01-29 2011-08-04 Genomatica, Inc. Micro-organismes et procedes pour la biosynthese de p-toluate et terephtalate
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
US8580543B2 (en) 2010-05-05 2013-11-12 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
CN103025877A (zh) 2010-07-26 2013-04-03 基因组股份公司 用于生物合成芳族化合物、2,4-戊二烯酸和1,3-丁二烯的微生物和方法
EP3628676A1 (fr) * 2018-09-28 2020-04-01 Université de Montpellier Peptides modifiés et leurs utilisations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE117724T1 (de) * 1989-07-04 1995-02-15 Lepetit Spa Antibiotikum ge 22270, faktoren a1,a2,a3 und h.

Also Published As

Publication number Publication date
IE920005A1 (en) 1992-07-15
FI932944A0 (fi) 1993-06-24
AU662122B2 (en) 1995-08-24
EP0565567B1 (fr) 1995-01-18
WO1992012172A1 (fr) 1992-07-23
AU1154492A (en) 1992-08-17
ATE117320T1 (de) 1995-02-15
JP3183508B2 (ja) 2001-07-09
KR930703355A (ko) 1993-11-29
ES2067325T3 (es) 1995-03-16
JPH06504768A (ja) 1994-06-02
CN1063110A (zh) 1992-07-29
FI932944A (fi) 1993-06-24
HU224072B1 (hu) 2005-05-30
CA2093219C (fr) 2002-04-09
NZ241216A (en) 1994-04-27
IL100572A0 (en) 1992-09-06
DE69201236D1 (de) 1995-03-02
HU9301941D0 (en) 1993-09-28
EP0565567A1 (fr) 1993-10-20
KR100225763B1 (ko) 1999-10-15
HUT64085A (en) 1993-11-29
ZA927B (en) 1992-09-30
EP0494078A1 (fr) 1992-07-08
DE69201236T2 (de) 1995-06-01
US5599791A (en) 1997-02-04
MX9200015A (es) 1992-07-31
CA2093219A1 (fr) 1992-07-04

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
HP Change in proprietorship
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees