DE69201236T2 - Amide der ge 2270-antibiotika. - Google Patents

Amide der ge 2270-antibiotika.

Info

Publication number
DE69201236T2
DE69201236T2 DE69201236T DE69201236T DE69201236T2 DE 69201236 T2 DE69201236 T2 DE 69201236T2 DE 69201236 T DE69201236 T DE 69201236T DE 69201236 T DE69201236 T DE 69201236T DE 69201236 T2 DE69201236 T2 DE 69201236T2
Authority
DE
Germany
Prior art keywords
antibiotics
amides
amide derivatives
antibiotic
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69201236T
Other languages
English (en)
Other versions
DE69201236D1 (de
Inventor
Paolo Tavecchia
Sergio Lociuro
Romeo Ciabatti
Enrico Selva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naicons SCARL
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Application granted granted Critical
Publication of DE69201236D1 publication Critical patent/DE69201236D1/de
Publication of DE69201236T2 publication Critical patent/DE69201236T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69201236T 1991-01-03 1992-01-02 Amide der ge 2270-antibiotika. Expired - Fee Related DE69201236T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91100123 1991-01-03
PCT/EP1992/000002 WO1992012172A1 (en) 1991-01-03 1992-01-02 Amides of antibiotic ge 2270 factors

Publications (2)

Publication Number Publication Date
DE69201236D1 DE69201236D1 (de) 1995-03-02
DE69201236T2 true DE69201236T2 (de) 1995-06-01

Family

ID=8206281

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69201236T Expired - Fee Related DE69201236T2 (de) 1991-01-03 1992-01-02 Amide der ge 2270-antibiotika.

Country Status (18)

Country Link
US (1) US5599791A (de)
EP (2) EP0494078A1 (de)
JP (1) JP3183508B2 (de)
KR (1) KR100225763B1 (de)
CN (1) CN1063110A (de)
AT (1) ATE117320T1 (de)
AU (1) AU662122B2 (de)
CA (1) CA2093219C (de)
DE (1) DE69201236T2 (de)
ES (1) ES2067325T3 (de)
FI (1) FI932944A (de)
HU (1) HU224072B1 (de)
IE (1) IE920005A1 (de)
IL (1) IL100572A (de)
MX (1) MX9200015A (de)
NZ (1) NZ241216A (de)
WO (1) WO1992012172A1 (de)
ZA (1) ZA927B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69108972T2 (de) * 1990-03-08 1995-10-19 Lepetit Spa Antibiotika GE 2270 Faktoren B1, B2, C1, D1, D2, E und T.
DK0529410T3 (da) * 1991-08-30 1998-05-11 Biosearch Italia Spa Antibiotikum GE 2270 faktor C2a
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
DE69317058T2 (de) * 1992-12-22 1998-06-10 Biosearch Italia Spa Die antibiotika ge 37468 a, b und c
ES2115424T3 (es) * 1995-02-07 1998-06-16 Biosearch Italia Spa Derivados prolin-amidicos basicos de los antibioticos ge 2270 y similares a ge 2270.
DK0808326T3 (da) * 1995-02-07 2001-10-01 Biosearch Italia Spa Basiske oxazolinamidderivater af GE2270 og GE2270-lignende antibiotika
KR19990082541A (ko) * 1996-02-14 1999-11-25 클라우디오 쿼르타 항생물질 ge2270 c2a, d2 및 e 인자의 유도체
JPH1059997A (ja) * 1996-08-22 1998-03-03 Microbial Chem Res Found アミチアマイシンアミド誘導体
US20050166498A1 (en) * 1999-12-17 2005-08-04 Oakey David D. Carpet tile with cutout section, method and apparatus for production and method of installation
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
WO2003105881A1 (en) * 2002-06-17 2003-12-24 Vicuron Pharmaceuticals Inc. Use of amide derivative of ge 2270 factor a3 for the treatment of acne
AU2004233557B2 (en) 2003-04-30 2010-02-18 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
KR101176450B1 (ko) 2003-12-18 2012-08-30 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 옥사졸리디논-퀴놀론 혼성 항생제
DE602005018898D1 (de) * 2004-01-19 2010-03-04 Dsm Ip Assets Bv Biochemische synthese von 6-aminocapronsäure
AR060977A1 (es) * 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos
AU2007339279A1 (en) * 2006-12-20 2008-07-10 Novartis Ag Aminothiazole macrocycles, their use as antibacterial compounds and processes for their production
WO2008091627A2 (en) 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
PE20090318A1 (es) * 2007-06-04 2009-04-17 Novartis Ag Macrociclos y sus usos
WO2009045637A2 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
BRPI0821138A2 (pt) * 2007-12-12 2015-06-16 Novatis Ag Aminotiazóis e seus usos
US8691553B2 (en) 2008-01-22 2014-04-08 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
PL2262901T3 (pl) 2008-03-05 2019-04-30 Genomatica Inc Organizmy wytwarzające alkohole pierwszorzędowe
CN103555643B (zh) 2008-03-27 2016-08-10 基因组股份公司 用于产生己二酸和其他化合物的微生物
EP2285973A4 (de) 2008-05-01 2012-04-25 Genomatica Inc Verfahren zur herstellung von methacrylsäure
BRPI0913901A2 (pt) 2008-06-17 2016-12-13 Genomatica Inc micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
AU2009327490A1 (en) 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
EP2425006A4 (de) 2009-04-30 2013-01-23 Genomatica Inc Organismen zur herstellung von isopropanol, n-butanol und isobutanol
EP2424975B1 (de) 2009-04-30 2016-07-06 Genomatica, Inc. Organismen zur herstellung von 1,3-butandiol
EP4273255A3 (de) 2009-05-07 2024-01-03 Genomatica, Inc. Mikroorganismen und verfahren für die biosynthese von hexamethylendiamin
US8663957B2 (en) 2009-05-15 2014-03-04 Genomatica, Inc. Organisms for the production of cyclohexanone
EP2440669A4 (de) 2009-06-10 2013-08-28 Genomatica Inc Mikrooganismen und verfahren für die kohlenstoffwirksame biosynthese mek und 2-butanol
EP2462221B1 (de) 2009-08-05 2017-02-22 Genomatica, Inc. Aus muconsäureproduzierenden mikroorganismen gewonnene halbsynthetische terephthalsäure
EP2475775A4 (de) 2009-09-09 2013-03-20 Genomatica Inc Mikroorganismen und verfahren zur gleichzeitigen herstellung von isopropanol und primären alkoholen, diolen und säuren
US8377666B2 (en) 2009-10-13 2013-02-19 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
EP2491125A4 (de) 2009-10-23 2014-04-23 Genomatica Inc Mikroorganismen zur herstellung von anilin
KR20120120493A (ko) 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
SG182686A1 (en) 2010-01-29 2012-08-30 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
MX336229B (es) 2010-05-05 2016-01-08 Genomatica Inc Microorganismos y metodos para la biosintesis de butadieno.
EP2607340B1 (de) 2010-07-26 2017-09-06 Genomatica, Inc. Microorganismen und Verfahren zur Biosynthese von Aromaten 2,4-Pentadienoat und 1,3-Butadien
EP3628676A1 (de) * 2018-09-28 2020-04-01 Université de Montpellier Modifizierte peptide und deren verwendungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139778A (en) * 1989-07-04 1992-08-18 Gruppo Lepetit Spa Antibiotic ge 2270 factors a1, a2, a3 and h

Also Published As

Publication number Publication date
ZA927B (en) 1992-09-30
HU224072B1 (hu) 2005-05-30
CA2093219C (en) 2002-04-09
FI932944A0 (fi) 1993-06-24
HUT64085A (en) 1993-11-29
JP3183508B2 (ja) 2001-07-09
IL100572A0 (en) 1992-09-06
IE920005A1 (en) 1992-07-15
US5599791A (en) 1997-02-04
KR100225763B1 (ko) 1999-10-15
EP0565567A1 (de) 1993-10-20
IL100572A (en) 1997-01-10
CN1063110A (zh) 1992-07-29
CA2093219A1 (en) 1992-07-04
FI932944A (fi) 1993-06-24
WO1992012172A1 (en) 1992-07-23
HU9301941D0 (en) 1993-09-28
AU1154492A (en) 1992-08-17
AU662122B2 (en) 1995-08-24
ATE117320T1 (de) 1995-02-15
NZ241216A (en) 1994-04-27
EP0494078A1 (de) 1992-07-08
EP0565567B1 (de) 1995-01-18
MX9200015A (es) 1992-07-31
JPH06504768A (ja) 1994-06-02
DE69201236D1 (de) 1995-03-02
ES2067325T3 (es) 1995-03-16
KR930703355A (ko) 1993-11-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOSEARCH ITALIA S.P.A., GERENZANO, IT

8327 Change in the person/name/address of the patent owner

Owner name: VICURON PHARMACEUTTICALS INC.(N.D.GES.STAATES DELA

8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: NAICONS S.C.A.R.L., MILANO, IT

8339 Ceased/non-payment of the annual fee