IE832198L - Imidazoles and intermediates. - Google Patents

Imidazoles and intermediates.

Info

Publication number
IE832198L
IE832198L IE832198A IE219883A IE832198L IE 832198 L IE832198 L IE 832198L IE 832198 A IE832198 A IE 832198A IE 219883 A IE219883 A IE 219883A IE 832198 L IE832198 L IE 832198L
Authority
IE
Ireland
Prior art keywords
imidazoles
alk
reactions
image
oxime
Prior art date
Application number
IE832198A
Other versions
IE55946B1 (en
Original Assignee
Gea Farmaceutisk Fabrik As
Mfg Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As, Mfg Co filed Critical Gea Farmaceutisk Fabrik As
Publication of IE832198L publication Critical patent/IE832198L/en
Publication of IE55946B1 publication Critical patent/IE55946B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

A new process is described for the production of 4-methyl-5-substituted- alkylthiomethyl-imidazoles, particularly Cimetidine of the formula <IMAGE> by the following series of reactions <IMAGE> wherein Alk<1> is alkylene preferably -CH2-CH2- and Alk<2> is C1-4 alkyl preferably CH3. The reactions for the selective reduction of Y and the deoxygenation may be effected in reverse order. The starting compound may have a second oxime group replacing the keto group or the oxime and keto groups shown may be transposed. The thioether cyanoguandines produced in the first reaction step are claimed as new compounds. [GB2129793A]
IE2198/83A 1982-10-08 1983-09-19 Thioethercyanoguanidines and their use as intermediates in producing imidazoles IE55946B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8228782 1982-10-08

Publications (2)

Publication Number Publication Date
IE832198L true IE832198L (en) 1984-04-08
IE55946B1 IE55946B1 (en) 1991-02-27

Family

ID=10533472

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2198/83A IE55946B1 (en) 1982-10-08 1983-09-19 Thioethercyanoguanidines and their use as intermediates in producing imidazoles

Country Status (18)

Country Link
JP (3) JPS5988472A (en)
AU (1) AU560031B2 (en)
BE (1) BE897952A (en)
CA (1) CA1199030A (en)
CH (2) CH659650A5 (en)
DE (1) DE3336225A1 (en)
DK (1) DK159309C (en)
FI (1) FI79301C (en)
FR (1) FR2534256B1 (en)
GB (1) GB2129793B (en)
IE (1) IE55946B1 (en)
NL (1) NL191181C (en)
NO (1) NO162018C (en)
NZ (1) NZ205652A (en)
PT (1) PT77468B (en)
SE (2) SE449746B (en)
ZA (1) ZA837237B (en)
ZW (1) ZW21383A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618846D0 (en) * 1986-08-01 1986-09-10 Smithkline Beckman Corp Chemical process
JPH0623179B2 (en) * 1986-09-01 1994-03-30 三井石油化学工業株式会社 Cyanoguanidine derivative and method for producing the same
JPH0629234B2 (en) * 1986-12-26 1994-04-20 三井石油化学工業株式会社 α-acyloxyketone derivative
JPH0623180B2 (en) * 1987-02-17 1994-03-30 三井石油化学工業株式会社 Cyanoguanidine derivative and method for producing the same
JPH0623181B2 (en) * 1987-02-17 1994-03-30 三井石油化学工業株式会社 Cyanoguanidine derivative and method for producing the same
JPS63208565A (en) * 1987-02-23 1988-08-30 Mitsui Petrochem Ind Ltd Production of guanidine derivative
JPS63208566A (en) * 1987-02-23 1988-08-30 Mitsui Petrochem Ind Ltd Production of guanidine derivative
JP3006356U (en) * 1994-04-12 1995-01-24 株式会社フコク Torsional vibration absorber
CN115745893A (en) * 2022-11-16 2023-03-07 西安近代化学研究所 Method for synthesizing 2-cyano-5-aryl-1H-imidazole compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

Also Published As

Publication number Publication date
AU1995683A (en) 1984-04-12
JPH0449539B2 (en) 1992-08-11
ZA837237B (en) 1984-11-28
SE8305508L (en) 1984-04-09
FR2534256A1 (en) 1984-04-13
NO833664L (en) 1984-04-09
DK451883A (en) 1984-04-09
CH659650A5 (en) 1987-02-13
PT77468B (en) 1986-02-12
FI833648A (en) 1984-04-09
DK451883D0 (en) 1983-09-30
NO162018C (en) 1989-10-25
FR2534256B1 (en) 1986-04-04
SE8500176D0 (en) 1985-01-15
BE897952A (en) 1984-01-30
SE459808B (en) 1989-08-07
GB2129793A (en) 1984-05-23
SE449746B (en) 1987-05-18
GB2129793B (en) 1986-03-12
JPS62161767A (en) 1987-07-17
PT77468A (en) 1983-11-01
JPS5988472A (en) 1984-05-22
ZW21383A1 (en) 1984-01-18
SE8305508D0 (en) 1983-10-06
FI79301C (en) 1989-12-11
NZ205652A (en) 1987-05-29
DE3336225C2 (en) 1993-06-24
DK159309C (en) 1991-03-11
NO162018B (en) 1989-07-17
JPH0579061B2 (en) 1993-11-01
CH660483A5 (en) 1987-04-30
IE55946B1 (en) 1991-02-27
FI833648A0 (en) 1983-10-07
NL191181B (en) 1994-10-03
FI79301B (en) 1989-08-31
CA1199030A (en) 1986-01-07
DE3336225A1 (en) 1984-04-12
JPS62161766A (en) 1987-07-17
AU560031B2 (en) 1987-03-26
GB8326767D0 (en) 1983-11-09
NL191181C (en) 1995-03-01
NL8303351A (en) 1984-05-01
SE8500176L (en) 1985-01-15
DK159309B (en) 1990-10-01

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