SE8305508L - PROCEDURE FOR PREPARING 4-METHYL-5-ALKYLTYOMETHYLIMIDAZOLES - Google Patents

PROCEDURE FOR PREPARING 4-METHYL-5-ALKYLTYOMETHYLIMIDAZOLES

Info

Publication number
SE8305508L
SE8305508L SE8305508A SE8305508A SE8305508L SE 8305508 L SE8305508 L SE 8305508L SE 8305508 A SE8305508 A SE 8305508A SE 8305508 A SE8305508 A SE 8305508A SE 8305508 L SE8305508 L SE 8305508L
Authority
SE
Sweden
Prior art keywords
methyl
alk
reactions
image
alkyltyomethylimidazoles
Prior art date
Application number
SE8305508A
Other languages
Swedish (sv)
Other versions
SE449746B (en
SE8305508D0 (en
Inventor
B Alhede
N Gelting
H Preikschat
F P Clausen
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Publication of SE8305508D0 publication Critical patent/SE8305508D0/en
Publication of SE8305508L publication Critical patent/SE8305508L/en
Publication of SE449746B publication Critical patent/SE449746B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Abstract

A new process is described for the production of 4-methyl-5-substituted- alkylthiomethyl-imidazoles, particularly Cimetidine of the formula <IMAGE> by the following series of reactions <IMAGE> wherein Alk<1> is alkylene preferably -CH2-CH2- and Alk<2> is C1-4 alkyl preferably CH3. The reactions for the selective reduction of Y and the deoxygenation may be effected in reverse order. The starting compound may have a second oxime group replacing the keto group or the oxime and keto groups shown may be transposed. The thioether cyanoguandines produced in the first reaction step are claimed as new compounds.
SE8305508A 1982-10-08 1983-10-06 PROCEDURE FOR PREPARING 4-METHYL-5-ALKYL-THIOIMIDAZOLES SE449746B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8228782 1982-10-08

Publications (3)

Publication Number Publication Date
SE8305508D0 SE8305508D0 (en) 1983-10-06
SE8305508L true SE8305508L (en) 1984-04-09
SE449746B SE449746B (en) 1987-05-18

Family

ID=10533472

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8305508A SE449746B (en) 1982-10-08 1983-10-06 PROCEDURE FOR PREPARING 4-METHYL-5-ALKYL-THIOIMIDAZOLES
SE8500176A SE459808B (en) 1982-10-08 1985-01-15 CHEMICAL COMPOSITION THAT CAN BE USED AS INTERMEDIATE FOR THE PREPARATION OF 4-METHYL-5-ALKYLTYOMETHYLIMIDAZOLES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8500176A SE459808B (en) 1982-10-08 1985-01-15 CHEMICAL COMPOSITION THAT CAN BE USED AS INTERMEDIATE FOR THE PREPARATION OF 4-METHYL-5-ALKYLTYOMETHYLIMIDAZOLES

Country Status (18)

Country Link
JP (3) JPS5988472A (en)
AU (1) AU560031B2 (en)
BE (1) BE897952A (en)
CA (1) CA1199030A (en)
CH (2) CH660483A5 (en)
DE (1) DE3336225A1 (en)
DK (1) DK159309C (en)
FI (1) FI79301C (en)
FR (1) FR2534256B1 (en)
GB (1) GB2129793B (en)
IE (1) IE55946B1 (en)
NL (1) NL191181C (en)
NO (1) NO162018C (en)
NZ (1) NZ205652A (en)
PT (1) PT77468B (en)
SE (2) SE449746B (en)
ZA (1) ZA837237B (en)
ZW (1) ZW21383A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618846D0 (en) * 1986-08-01 1986-09-10 Smithkline Beckman Corp Chemical process
JPH0623179B2 (en) * 1986-09-01 1994-03-30 三井石油化学工業株式会社 Cyanoguanidine derivative and method for producing the same
JPH0629234B2 (en) * 1986-12-26 1994-04-20 三井石油化学工業株式会社 α-acyloxyketone derivative
JPH0623181B2 (en) * 1987-02-17 1994-03-30 三井石油化学工業株式会社 Cyanoguanidine derivative and method for producing the same
JPH0623180B2 (en) * 1987-02-17 1994-03-30 三井石油化学工業株式会社 Cyanoguanidine derivative and method for producing the same
JPS63208565A (en) * 1987-02-23 1988-08-30 Mitsui Petrochem Ind Ltd Production of guanidine derivative
JPS63208566A (en) * 1987-02-23 1988-08-30 Mitsui Petrochem Ind Ltd Production of guanidine derivative
JP3006356U (en) * 1994-04-12 1995-01-24 株式会社フコク Torsional vibration absorber

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

Also Published As

Publication number Publication date
FI79301B (en) 1989-08-31
CA1199030A (en) 1986-01-07
DK159309B (en) 1990-10-01
FI833648A0 (en) 1983-10-07
FI833648A (en) 1984-04-09
PT77468B (en) 1986-02-12
JPH0449539B2 (en) 1992-08-11
JPS62161767A (en) 1987-07-17
DK159309C (en) 1991-03-11
PT77468A (en) 1983-11-01
FI79301C (en) 1989-12-11
DE3336225C2 (en) 1993-06-24
FR2534256A1 (en) 1984-04-13
CH659650A5 (en) 1987-02-13
JPH0579061B2 (en) 1993-11-01
NO833664L (en) 1984-04-09
GB2129793B (en) 1986-03-12
CH660483A5 (en) 1987-04-30
NO162018B (en) 1989-07-17
SE449746B (en) 1987-05-18
SE8500176L (en) 1985-01-15
AU1995683A (en) 1984-04-12
NZ205652A (en) 1987-05-29
NL8303351A (en) 1984-05-01
GB2129793A (en) 1984-05-23
ZW21383A1 (en) 1984-01-18
SE8305508D0 (en) 1983-10-06
NL191181B (en) 1994-10-03
JPS62161766A (en) 1987-07-17
SE8500176D0 (en) 1985-01-15
DE3336225A1 (en) 1984-04-12
NL191181C (en) 1995-03-01
JPS5988472A (en) 1984-05-22
SE459808B (en) 1989-08-07
DK451883D0 (en) 1983-09-30
FR2534256B1 (en) 1986-04-04
ZA837237B (en) 1984-11-28
DK451883A (en) 1984-04-09
NO162018C (en) 1989-10-25
IE832198L (en) 1984-04-08
BE897952A (en) 1984-01-30
IE55946B1 (en) 1991-02-27
GB8326767D0 (en) 1983-11-09
AU560031B2 (en) 1987-03-26

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