IE81129B1 - Molecular cloning and expression of human IL-3 - Google Patents

Molecular cloning and expression of human IL-3

Info

Publication number
IE81129B1
IE81129B1 IE340987A IE340987A IE81129B1 IE 81129 B1 IE81129 B1 IE 81129B1 IE 340987 A IE340987 A IE 340987A IE 340987 A IE340987 A IE 340987A IE 81129 B1 IE81129 B1 IE 81129B1
Authority
IE
Ireland
Prior art keywords
human
protein
sequence
pgb
host cell
Prior art date
Application number
IE340987A
Other languages
English (en)
Other versions
IE873409L (en
Inventor
Lambertus Christiaan Dorssers
Gerard Wagemaker
Yvonne Johanna Vos
Robert Willem Van Leen
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of IE873409L publication Critical patent/IE873409L/xx
Publication of IE81129B1 publication Critical patent/IE81129B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IE340987A 1986-12-16 1987-12-16 Molecular cloning and expression of human IL-3 IE81129B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP86202285 1986-12-16
EP87201322 1987-07-13

Publications (2)

Publication Number Publication Date
IE873409L IE873409L (en) 1988-06-12
IE81129B1 true IE81129B1 (en) 2000-03-22

Family

ID=26103432

Family Applications (1)

Application Number Title Priority Date Filing Date
IE340987A IE81129B1 (en) 1986-12-16 1987-12-16 Molecular cloning and expression of human IL-3

Country Status (14)

Country Link
JP (2) JPH01502157A (fi)
AT (1) ATE161882T1 (fi)
AU (1) AU617095B2 (fi)
CA (1) CA1341503C (fi)
DE (1) DE3752158T2 (fi)
ES (1) ES2113338T3 (fi)
FI (1) FI102293B1 (fi)
GR (1) GR3025857T3 (fi)
IE (1) IE81129B1 (fi)
IL (1) IL84852A (fi)
NO (1) NO180544C (fi)
NZ (1) NZ222939A (fi)
PT (1) PT86381B (fi)
WO (1) WO1988004691A1 (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US6238889B1 (en) 1986-12-16 2001-05-29 Dsm N.V. Molecular cloning and expression of the Pro8 isoform of human IL-3
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
US5304637A (en) * 1987-07-13 1994-04-19 Gist-Brocades N.V. Expression and purification of human interleukin-3 and muteins thereof
GB2210883B (en) * 1987-10-08 1992-01-02 British Bio Technology Synthetic interleukin-3 gene
US6384194B1 (en) 1987-12-16 2002-05-07 Dsm N.V. Expression and purification of human interleukin-3 and muteins thereof
JPH04500508A (ja) * 1988-07-20 1992-01-30 イミュネックス・コーポレーション 非グリコシル化　ヒト　インターロイキン―３　組成物
NZ232913A (en) * 1989-03-15 1992-08-26 Gist Brocades Nv Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
EP0413383B1 (en) 1989-08-14 1997-06-18 Gist-Brocades N.V. Mutants of human interleukin-3
DE69125292T2 (de) * 1991-08-01 1997-09-25 Fond Nat Transfusion Sanguine Expression in nicht-tumorbildenden menschlichen Lymphoblasten Zellinien mit einem integrierenden Vektor
ATE251669T1 (de) * 1992-11-24 2003-10-15 Searle & Co Mutierte polypeptide des interleukin-3(il-3)
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
WO1999041382A2 (en) * 1998-02-17 1999-08-19 Hyseq, Inc. A novel interleukin-3 and uses thereof
JP2008527981A (ja) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド 治療目的および診断目的のためにパラメーターにより選択されたｇｍ−ｃｓｆ、ｉｌ−３、ｉｌ−４、ｉｌ−５、ならびにそのキメラ
JP2009532061A (ja) * 2006-04-03 2009-09-10 ニユー・イングランド・バイオレイブス・インコーポレイテツド 組換えウシ血清アルブミン（ｒＢＳＡ）の発現、分泌及び精製、並びにその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
AU570762B2 (en) * 1983-12-23 1988-03-24 Australian National University, The Cloning of cdna for il-3
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors

Also Published As

Publication number Publication date
DE3752158D1 (de) 1998-02-12
FI102293B (fi) 1998-11-13
ES2113338T3 (es) 1998-05-01
NZ222939A (en) 1991-03-26
FI883688A (fi) 1988-08-08
JPH1080286A (ja) 1998-03-31
IE873409L (en) 1988-06-12
FI102293B1 (fi) 1998-11-13
IL84852A (en) 1994-06-24
GR3025857T3 (en) 1998-04-30
NO883614L (no) 1988-08-12
NO883614D0 (no) 1988-08-12
JPH01502157A (ja) 1989-08-03
ATE161882T1 (de) 1998-01-15
CA1341503C (en) 2006-04-04
NO180544C (no) 1997-05-07
DE3752158T2 (de) 1998-05-20
FI883688A0 (fi) 1988-08-08
NO180544B (no) 1997-01-27
AU617095B2 (en) 1991-11-21
WO1988004691A1 (en) 1988-06-30
PT86381B (pt) 1990-11-20
AU1057788A (en) 1988-07-15
PT86381A (en) 1988-01-01
IL84852A0 (en) 1988-06-30

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