IE780332L - Free-flowing composition - Google Patents
Free-flowing compositionInfo
- Publication number
- IE780332L IE780332L IE780332A IE33278A IE780332L IE 780332 L IE780332 L IE 780332L IE 780332 A IE780332 A IE 780332A IE 33278 A IE33278 A IE 33278A IE 780332 L IE780332 L IE 780332L
- Authority
- IE
- Ireland
- Prior art keywords
- free
- composition
- adsorbate
- water
- pharmacologically acceptable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000002156 adsorbate Substances 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 229920000831 ionic polymer Polymers 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000003352 sequestering agent Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
A pharmacologically acceptable bile acid sequestering agent composition which after the prolonged action of moist air does not stick and is free-flowing, contains an essentially uniform adsorbate of a quaternary ionic polymer on a finely divided, water-insoluble, solid, pharmacologically acceptable aggregate having a large surface-to-mass ratio. The composition is prepared by mixing the component in aqueous solution, evaporating the water and drying the adsorbate thus formed. The composition described can be used for the reduction of cholesterol in the blood.
[GB1567294A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76949177A | 1977-02-17 | 1977-02-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE780332L true IE780332L (en) | 1978-08-17 |
| IE46408B1 IE46408B1 (en) | 1983-06-01 |
Family
ID=25085598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE332/78A IE46408B1 (en) | 1977-02-17 | 1978-02-16 | Pharmaceutical compositions |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS53102958A (en) |
| AT (1) | AT363173B (en) |
| AU (1) | AU518127B2 (en) |
| BE (1) | BE863930A (en) |
| CA (1) | CA1109395A (en) |
| CH (1) | CH636012A5 (en) |
| DE (1) | DE2806707A1 (en) |
| DK (1) | DK46578A (en) |
| ES (1) | ES466892A1 (en) |
| FI (1) | FI67483C (en) |
| FR (1) | FR2381079A1 (en) |
| GB (1) | GB1567294A (en) |
| GR (1) | GR66100B (en) |
| HU (1) | HU177685B (en) |
| IE (1) | IE46408B1 (en) |
| IL (1) | IL53978A (en) |
| IT (1) | IT7848013A0 (en) |
| LU (1) | LU79071A1 (en) |
| NL (1) | NL7801240A (en) |
| NO (1) | NO148838C (en) |
| NZ (1) | NZ186399A (en) |
| PH (1) | PH15263A (en) |
| PL (1) | PL122299B1 (en) |
| PT (1) | PT67663B (en) |
| SE (1) | SE433170B (en) |
| ZA (1) | ZA78913B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
| US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
| US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US5709880A (en) * | 1995-07-10 | 1998-01-20 | Buckman Laboratories International, Inc. | Method of making tabletized ionene polymers |
| EP0778027A3 (en) | 1995-12-04 | 1998-04-01 | Helmut Univ.-Prof. Dr. Wachter | Use of silica for the preparation of a medicament |
| JP4010585B2 (en) * | 1996-10-15 | 2007-11-21 | 久光製薬株式会社 | Tablets containing anion exchange resin |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| CN116925354B (en) * | 2023-07-20 | 2025-09-23 | 黑龙江省科学院石油化学研究院 | A high-strength polyimide aerogel corrugated paper and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206115A1 (en) * | 1973-06-11 | 1976-06-30 | Merck & Co Inc | PROCEDURE TO PREPARE A NON-BRANCHED AND NON-CROSSLINK LINEAR POLYMER |
| US4027009A (en) * | 1973-06-11 | 1977-05-31 | Merck & Co., Inc. | Compositions and methods for depressing blood serum cholesterol |
-
1978
- 1978-01-30 FI FI780296A patent/FI67483C/en not_active IP Right Cessation
- 1978-02-01 DK DK46578A patent/DK46578A/en not_active Application Discontinuation
- 1978-02-02 NO NO780367A patent/NO148838C/en unknown
- 1978-02-02 SE SE7801242A patent/SE433170B/en unknown
- 1978-02-02 NL NL7801240A patent/NL7801240A/en not_active Application Discontinuation
- 1978-02-06 IL IL53978A patent/IL53978A/en unknown
- 1978-02-06 GR GR55356A patent/GR66100B/el unknown
- 1978-02-06 PH PH20753A patent/PH15263A/en unknown
- 1978-02-07 NZ NZ186399A patent/NZ186399A/en unknown
- 1978-02-08 AU AU33099/78A patent/AU518127B2/en not_active Expired
- 1978-02-08 CA CA296,622A patent/CA1109395A/en not_active Expired
- 1978-02-08 AT AT0087978A patent/AT363173B/en not_active IP Right Cessation
- 1978-02-09 HU HU78ME2145A patent/HU177685B/en unknown
- 1978-02-10 ES ES466892A patent/ES466892A1/en not_active Expired
- 1978-02-10 IT IT7848013A patent/IT7848013A0/en unknown
- 1978-02-14 BE BE185141A patent/BE863930A/en not_active IP Right Cessation
- 1978-02-14 CH CH162578A patent/CH636012A5/en not_active IP Right Cessation
- 1978-02-15 LU LU79071A patent/LU79071A1/en unknown
- 1978-02-15 FR FR7804268A patent/FR2381079A1/en active Granted
- 1978-02-15 GB GB6014/78A patent/GB1567294A/en not_active Expired
- 1978-02-15 PL PL1978204642A patent/PL122299B1/en unknown
- 1978-02-16 PT PT67663A patent/PT67663B/en unknown
- 1978-02-16 DE DE19782806707 patent/DE2806707A1/en not_active Withdrawn
- 1978-02-16 ZA ZA00780913A patent/ZA78913B/en unknown
- 1978-02-16 IE IE332/78A patent/IE46408B1/en unknown
- 1978-02-17 JP JP1666278A patent/JPS53102958A/en active Pending
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