IE780332L - Free-flowing composition - Google Patents

Free-flowing composition

Info

Publication number
IE780332L
IE780332L IE780332A IE33278A IE780332L IE 780332 L IE780332 L IE 780332L IE 780332 A IE780332 A IE 780332A IE 33278 A IE33278 A IE 33278A IE 780332 L IE780332 L IE 780332L
Authority
IE
Ireland
Prior art keywords
free
composition
adsorbate
water
pharmacologically acceptable
Prior art date
Application number
IE780332A
Other versions
IE46408B1 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE780332L publication Critical patent/IE780332L/en
Publication of IE46408B1 publication Critical patent/IE46408B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

A pharmacologically acceptable bile acid sequestering agent composition which after the prolonged action of moist air does not stick and is free-flowing, contains an essentially uniform adsorbate of a quaternary ionic polymer on a finely divided, water-insoluble, solid, pharmacologically acceptable aggregate having a large surface-to-mass ratio. The composition is prepared by mixing the component in aqueous solution, evaporating the water and drying the adsorbate thus formed. The composition described can be used for the reduction of cholesterol in the blood. [GB1567294A]
IE332/78A 1977-02-17 1978-02-16 Pharmaceutical compositions IE46408B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76949177A 1977-02-17 1977-02-17

Publications (2)

Publication Number Publication Date
IE780332L true IE780332L (en) 1978-08-17
IE46408B1 IE46408B1 (en) 1983-06-01

Family

ID=25085598

Family Applications (1)

Application Number Title Priority Date Filing Date
IE332/78A IE46408B1 (en) 1977-02-17 1978-02-16 Pharmaceutical compositions

Country Status (26)

Country Link
JP (1) JPS53102958A (en)
AT (1) AT363173B (en)
AU (1) AU518127B2 (en)
BE (1) BE863930A (en)
CA (1) CA1109395A (en)
CH (1) CH636012A5 (en)
DE (1) DE2806707A1 (en)
DK (1) DK46578A (en)
ES (1) ES466892A1 (en)
FI (1) FI67483C (en)
FR (1) FR2381079A1 (en)
GB (1) GB1567294A (en)
GR (1) GR66100B (en)
HU (1) HU177685B (en)
IE (1) IE46408B1 (en)
IL (1) IL53978A (en)
IT (1) IT7848013A0 (en)
LU (1) LU79071A1 (en)
NL (1) NL7801240A (en)
NO (1) NO148838C (en)
NZ (1) NZ186399A (en)
PH (1) PH15263A (en)
PL (1) PL122299B1 (en)
PT (1) PT67663B (en)
SE (1) SE433170B (en)
ZA (1) ZA78913B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5709880A (en) * 1995-07-10 1998-01-20 Buckman Laboratories International, Inc. Method of making tabletized ionene polymers
EP0778027A3 (en) 1995-12-04 1998-04-01 Helmut Univ.-Prof. Dr. Wachter Use of silica for the preparation of a medicament
JP4010585B2 (en) * 1996-10-15 2007-11-21 久光製薬株式会社 Tablets containing anion exchange resin
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206115A1 (en) * 1973-06-11 1976-06-30 Merck & Co Inc PROCEDURE TO PREPARE A NON-BRANCHED AND NON-CROSSLINK LINEAR POLYMER
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol

Also Published As

Publication number Publication date
AT363173B (en) 1981-07-10
PT67663B (en) 1980-03-03
IE46408B1 (en) 1983-06-01
CA1109395A (en) 1981-09-22
ES466892A1 (en) 1979-08-16
GR66100B (en) 1981-01-16
PT67663A (en) 1978-03-01
NO148838B (en) 1983-09-19
SE7801242L (en) 1978-08-18
ATA87978A (en) 1980-12-15
ZA78913B (en) 1979-09-26
PL122299B1 (en) 1982-07-31
HU177685B (en) 1981-12-28
GB1567294A (en) 1980-05-14
SE433170B (en) 1984-05-14
IL53978A0 (en) 1978-04-30
BE863930A (en) 1978-08-14
PH15263A (en) 1982-11-02
CH636012A5 (en) 1983-05-13
AU3309978A (en) 1979-08-16
IL53978A (en) 1981-03-31
LU79071A1 (en) 1978-09-28
NO780367L (en) 1978-08-18
IT7848013A0 (en) 1978-02-10
FR2381079B1 (en) 1981-09-11
NL7801240A (en) 1978-08-21
NZ186399A (en) 1980-11-28
FI780296A (en) 1978-08-18
FI67483C (en) 1985-04-10
JPS53102958A (en) 1978-09-07
FR2381079A1 (en) 1978-09-15
AU518127B2 (en) 1981-09-17
DK46578A (en) 1978-08-18
NO148838C (en) 1983-12-28
PL204642A1 (en) 1979-06-04
FI67483B (en) 1984-12-31
DE2806707A1 (en) 1978-08-24

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