FR2381079A1 - NON-ADHESIVE COMPOSITIONS OF QUATERNARY POLYMERS OF IONENE, AND THEIR PREPARATION PROCESS - Google Patents
NON-ADHESIVE COMPOSITIONS OF QUATERNARY POLYMERS OF IONENE, AND THEIR PREPARATION PROCESSInfo
- Publication number
- FR2381079A1 FR2381079A1 FR7804268A FR7804268A FR2381079A1 FR 2381079 A1 FR2381079 A1 FR 2381079A1 FR 7804268 A FR7804268 A FR 7804268A FR 7804268 A FR7804268 A FR 7804268A FR 2381079 A1 FR2381079 A1 FR 2381079A1
- Authority
- FR
- France
- Prior art keywords
- ionene
- quaternary
- adhesive compositions
- trimethyleneõ
- iminio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
L'invention se rapporte à des compositions non-adhésives de polymères quaternaires d'ionène, et leur procédé de préparation. L'invention concerne une nouvelle composition pharmacologiquement acceptable, non-adhésive, sous la forme d'une poudre qui roule, comprenant des polymères quaternaires d'ionène efficaces comme séquestrants des acides biliaires, comme du polyØdichlorure de (méthyl-(3-triméthylammoniopropyl)iminio)triméthylèneõ, adsorbés sur un agrégat solide pulverulent d'une grande surface spécifique, comme de la silice fumée. Elle concerne aussi un procédé nouveau pour préparer de telles compositions d'adsorbat, selon lequel on forme une suspension sensiblement uniforme de l'agrégat solide finement divisé dans une solution aqueuse de pollyØdichlorure de (méthyl-(3-triméthylammoniopropyl)iminio)triméthylèneõ, on élimine par évaporation l'eau de la suspension et on sèche l'adsorbat ainsi produit Application à la séquestration des acides biliaires.The invention relates to non-adhesive compositions of quaternary ionene polymers, and a process for their preparation. Disclosed is a novel, pharmacologically acceptable, non-stick, powder-rolling composition comprising quaternary ionene polymers effective as bile acid sequestrants, such as (methyl- (3-trimethylammoniopropyl) polyidichloride. iminio) trimethyleneõ, adsorbed on a pulverulent solid aggregate with a large specific surface area, such as fumed silica. It also relates to a novel process for preparing such adsorbate compositions, according to which a substantially uniform suspension of the finely divided solid aggregate is formed in an aqueous solution of (methyl- (3-trimethylammoniopropyl) iminio) trimethyleneõ pollyodichloride, one the water is removed from the suspension by evaporation and the adsorbate thus produced is dried. Application to the sequestration of bile acids.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76949177A | 1977-02-17 | 1977-02-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2381079A1 true FR2381079A1 (en) | 1978-09-15 |
| FR2381079B1 FR2381079B1 (en) | 1981-09-11 |
Family
ID=25085598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7804268A Granted FR2381079A1 (en) | 1977-02-17 | 1978-02-15 | NON-ADHESIVE COMPOSITIONS OF QUATERNARY POLYMERS OF IONENE, AND THEIR PREPARATION PROCESS |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS53102958A (en) |
| AT (1) | AT363173B (en) |
| AU (1) | AU518127B2 (en) |
| BE (1) | BE863930A (en) |
| CA (1) | CA1109395A (en) |
| CH (1) | CH636012A5 (en) |
| DE (1) | DE2806707A1 (en) |
| DK (1) | DK46578A (en) |
| ES (1) | ES466892A1 (en) |
| FI (1) | FI67483C (en) |
| FR (1) | FR2381079A1 (en) |
| GB (1) | GB1567294A (en) |
| GR (1) | GR66100B (en) |
| HU (1) | HU177685B (en) |
| IE (1) | IE46408B1 (en) |
| IL (1) | IL53978A (en) |
| IT (1) | IT7848013A0 (en) |
| LU (1) | LU79071A1 (en) |
| NL (1) | NL7801240A (en) |
| NO (1) | NO148838C (en) |
| NZ (1) | NZ186399A (en) |
| PH (1) | PH15263A (en) |
| PL (1) | PL122299B1 (en) |
| PT (1) | PT67663B (en) |
| SE (1) | SE433170B (en) |
| ZA (1) | ZA78913B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
| US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| TW474813B (en) * | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US5709880A (en) * | 1995-07-10 | 1998-01-20 | Buckman Laboratories International, Inc. | Method of making tabletized ionene polymers |
| EP0778027A3 (en) | 1995-12-04 | 1998-04-01 | Helmut Univ.-Prof. Dr. Wachter | Use of silica for the preparation of a medicament |
| JP4010585B2 (en) * | 1996-10-15 | 2007-11-21 | 久光製薬株式会社 | Tablets containing anion exchange resin |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2241321A1 (en) * | 1973-06-11 | 1975-03-21 | Merck & Co Inc |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR206115A1 (en) * | 1973-06-11 | 1976-06-30 | Merck & Co Inc | PROCEDURE TO PREPARE A NON-BRANCHED AND NON-CROSSLINK LINEAR POLYMER |
-
1978
- 1978-01-30 FI FI780296A patent/FI67483C/en not_active IP Right Cessation
- 1978-02-01 DK DK46578A patent/DK46578A/en not_active Application Discontinuation
- 1978-02-02 NL NL7801240A patent/NL7801240A/en not_active Application Discontinuation
- 1978-02-02 SE SE7801242A patent/SE433170B/en unknown
- 1978-02-02 NO NO780367A patent/NO148838C/en unknown
- 1978-02-06 PH PH20753A patent/PH15263A/en unknown
- 1978-02-06 GR GR55356A patent/GR66100B/el unknown
- 1978-02-06 IL IL53978A patent/IL53978A/en unknown
- 1978-02-07 NZ NZ186399A patent/NZ186399A/en unknown
- 1978-02-08 AT AT0087978A patent/AT363173B/en not_active IP Right Cessation
- 1978-02-08 AU AU33099/78A patent/AU518127B2/en not_active Expired
- 1978-02-08 CA CA296,622A patent/CA1109395A/en not_active Expired
- 1978-02-09 HU HU78ME2145A patent/HU177685B/en unknown
- 1978-02-10 IT IT7848013A patent/IT7848013A0/en unknown
- 1978-02-10 ES ES466892A patent/ES466892A1/en not_active Expired
- 1978-02-14 BE BE185141A patent/BE863930A/en not_active IP Right Cessation
- 1978-02-14 CH CH162578A patent/CH636012A5/en not_active IP Right Cessation
- 1978-02-15 GB GB6014/78A patent/GB1567294A/en not_active Expired
- 1978-02-15 LU LU79071A patent/LU79071A1/en unknown
- 1978-02-15 FR FR7804268A patent/FR2381079A1/en active Granted
- 1978-02-15 PL PL1978204642A patent/PL122299B1/en unknown
- 1978-02-16 IE IE332/78A patent/IE46408B1/en unknown
- 1978-02-16 ZA ZA00780913A patent/ZA78913B/en unknown
- 1978-02-16 DE DE19782806707 patent/DE2806707A1/en not_active Withdrawn
- 1978-02-16 PT PT67663A patent/PT67663B/en unknown
- 1978-02-17 JP JP1666278A patent/JPS53102958A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2241321A1 (en) * | 1973-06-11 | 1975-03-21 | Merck & Co Inc |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |