IE69315B1 - Hypotriglyceridemic use of certain bis(3,5-di-alkyl-4-hydroxyphenylthio)methanes - Google Patents

Hypotriglyceridemic use of certain bis(3,5-di-alkyl-4-hydroxyphenylthio)methanes

Info

Publication number
IE69315B1
IE69315B1 IE208791A IE208791A IE69315B1 IE 69315 B1 IE69315 B1 IE 69315B1 IE 208791 A IE208791 A IE 208791A IE 208791 A IE208791 A IE 208791A IE 69315 B1 IE69315 B1 IE 69315B1
Authority
IE
Ireland
Prior art keywords
hypertriglyceridemia
compound
hydroxyphenylthio
bis
alkyl
Prior art date
Application number
IE208791A
Other languages
English (en)
Other versions
IE912087A1 (en
Inventor
Mao Simon Jen Tan
Ku George
Jackson Richard Lee
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IE912087A1 publication Critical patent/IE912087A1/en
Publication of IE69315B1 publication Critical patent/IE69315B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IE208791A 1990-06-19 1991-06-18 Hypotriglyceridemic use of certain bis(3,5-di-alkyl-4-hydroxyphenylthio)methanes IE69315B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/540,657 US5122542A (en) 1990-06-19 1990-06-19 Hypotriglyceridemic use of certain bis (3,5-di-alkyl-4-hydroxyphenylthio)methanes

Publications (2)

Publication Number Publication Date
IE912087A1 IE912087A1 (en) 1992-01-01
IE69315B1 true IE69315B1 (en) 1996-09-04

Family

ID=24156398

Family Applications (1)

Application Number Title Priority Date Filing Date
IE208791A IE69315B1 (en) 1990-06-19 1991-06-18 Hypotriglyceridemic use of certain bis(3,5-di-alkyl-4-hydroxyphenylthio)methanes

Country Status (13)

Country Link
US (1) US5122542A (enExample)
EP (1) EP0462556B1 (enExample)
JP (1) JPH04230213A (enExample)
KR (1) KR0168649B1 (enExample)
AT (1) ATE129151T1 (enExample)
AU (1) AU640486B2 (enExample)
DE (1) DE69113871T2 (enExample)
DK (1) DK0462556T3 (enExample)
ES (1) ES2080854T3 (enExample)
GR (1) GR3018351T3 (enExample)
IE (1) IE69315B1 (enExample)
TW (1) TW205542B (enExample)
ZA (1) ZA914538B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100004333A1 (en) * 2004-12-17 2010-01-07 Stocker Roland O Compositions and methods for treating cardiovascular disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734527A (en) * 1986-10-17 1988-03-29 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US4954528A (en) * 1988-12-08 1990-09-04 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic use of bis(3,5-di-tertiary-butly-4-hydroxyphenylthio)methane
US4959392A (en) * 1989-07-24 1990-09-25 Merrell Dow Pharmaceuticals Inc. Method of treating diabetes mellitus

Also Published As

Publication number Publication date
AU7836591A (en) 1992-01-02
EP0462556A3 (en) 1992-03-11
TW205542B (enExample) 1993-05-11
GR3018351T3 (en) 1996-03-31
AU640486B2 (en) 1993-08-26
KR920000327A (ko) 1992-01-29
DE69113871T2 (de) 1996-04-04
KR0168649B1 (ko) 1999-01-15
JPH04230213A (ja) 1992-08-19
EP0462556A2 (en) 1991-12-27
EP0462556B1 (en) 1995-10-18
ZA914538B (en) 1992-03-25
US5122542A (en) 1992-06-16
DK0462556T3 (da) 1995-11-27
ATE129151T1 (de) 1995-11-15
ES2080854T3 (es) 1996-02-16
IE912087A1 (en) 1992-01-01
DE69113871D1 (de) 1995-11-23

Similar Documents

Publication Publication Date Title
US4900757A (en) Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
JP2963556B2 (ja) 抗アテロ−ム性動脈硬化症剤としての新規な2,6−ジ−アルキル−4−シリル−フェノ−ル類
EP0732928B1 (en) Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
JP2963557B2 (ja) 抗アテロ−ム性動脈硬化症剤としての新規なビス[4−(2,6−ジ−アルキル)フェノ−ル]シラン誘導体類
EP0462556B1 (en) Hypotriglyceridemic use of certain bis(3,5-di-alkyl-4-hydroxphenylthio)methanes
AU705029B2 (en) Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide derivatives
US4959392A (en) Method of treating diabetes mellitus
US4954528A (en) Hypocholesterolemic use of bis(3,5-di-tertiary-butly-4-hydroxyphenylthio)methane
US6013645A (en) Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
EP0504807B1 (en) Use of bis-(p-hydroxyphenylthio)methane derivatives to inhibit progressive development of insulin-dependent diabetes mellitus

Legal Events

Date Code Title Description
MM4A Patent lapsed