IE65247B1 - Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-ones and thiones and their use in the prevention or treatment of aids - Google Patents

Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-ones and thiones and their use in the prevention or treatment of aids

Info

Publication number
IE65247B1
IE65247B1 IE232290A IE232290A IE65247B1 IE 65247 B1 IE65247 B1 IE 65247B1 IE 232290 A IE232290 A IE 232290A IE 232290 A IE232290 A IE 232290A IE 65247 B1 IE65247 B1 IE 65247B1
Authority
IE
Ireland
Prior art keywords
hydrogen
formula
compound
alkyl
optionally substituted
Prior art date
Application number
IE232290A
Other languages
English (en)
Other versions
IE902322A1 (en
IE902322L (en
Inventor
Gunther Dr Schmidt
Wolfhard Dr Engel
Gunter Dr Trummlitz
Wolfgang Dr Eberlein
Karl D Dr Hargrave
Original Assignee
Thomae Gmbh Dr K
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K, Boehringer Ingelheim Pharma filed Critical Thomae Gmbh Dr K
Publication of IE902322L publication Critical patent/IE902322L/en
Publication of IE902322A1 publication Critical patent/IE902322A1/en
Publication of IE65247B1 publication Critical patent/IE65247B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IE232290A 1989-06-28 1990-06-27 Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-ones and thiones and their use in the prevention or treatment of aids IE65247B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37297489A 1989-06-28 1989-06-28

Publications (3)

Publication Number Publication Date
IE902322L IE902322L (en) 1990-12-28
IE902322A1 IE902322A1 (en) 1991-01-16
IE65247B1 true IE65247B1 (en) 1995-10-18

Family

ID=23470402

Family Applications (1)

Application Number Title Priority Date Filing Date
IE232290A IE65247B1 (en) 1989-06-28 1990-06-27 Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4] diazepin-6-ones and thiones and their use in the prevention or treatment of aids

Country Status (21)

Country Link
EP (1) EP0410148B1 (enExample)
JP (1) JP2911967B2 (enExample)
KR (1) KR0160285B1 (enExample)
AP (1) AP189A (enExample)
AT (1) ATE103918T1 (enExample)
AU (1) AU620724B2 (enExample)
CA (1) CA2019812C (enExample)
DD (1) DD295849A5 (enExample)
DE (1) DE69007891T2 (enExample)
DK (1) DK0410148T3 (enExample)
ES (1) ES2063202T3 (enExample)
FI (1) FI92828C (enExample)
HU (1) HU206504B (enExample)
IE (1) IE65247B1 (enExample)
IL (1) IL94883A (enExample)
NO (1) NO174468B (enExample)
NZ (1) NZ234261A (enExample)
OA (1) OA09741A (enExample)
PT (1) PT94521B (enExample)
RU (1) RU2024522C1 (enExample)
ZA (1) ZA904991B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3802334A1 (de) * 1988-01-27 1989-08-10 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
JP2912007B2 (ja) * 1989-11-17 1999-06-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレーテッド ５，１１―ジヒドロ―６Ｈ―ジピリド〔３，２―ｂ：２′，３′―ｅ〕〔１，４〕ジアゼピンおよび該化合物を含有するＨＩＶ感染の予防又は治療用組成物
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
DE69213777T2 (de) * 1991-02-07 1997-03-13 Boehringer Ingelheim Pharma Pyridobenzodiazepine, Dipyrido-[3,2-b:2',3'-3] [1,4]-diazepine und deren Verwendung in der Vorbeugung und Behandlung von AIDS
DE4403311C1 (de) * 1994-02-03 1995-04-20 Boehringer Ingelheim Kg Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on)
AU690646B2 (en) * 1994-02-18 1998-04-30 Boehringer Ingelheim Pharmaceuticals, Inc. 2-heteroaryl-5,11-dihydro-6H-dipyrido(3,2-b:2',3'-e)(1 ,4)diazepines and their use in the prevention or treatment of HIV infection
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
PL192361B1 (pl) * 1997-08-25 2006-10-31 Boehringer Ingelheim Pharma Kompozycja farmaceutyczna hemihydratu newirapiny i sposób wytwarzania wodnej zawiesiny hemihydratu newirapiny
DE10023492A1 (de) * 2000-05-09 2001-11-22 Schering Ag Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
RU2270195C1 (ru) * 2004-06-21 2006-02-20 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" ГОУ ВПО ЮРГТУ(НПИ) Способ получения 5-амино-3-[n-ацил-n-алкиламино]-1-фенил-1,2,4-триазолов и 5-амино-3-[n-сульфонил-n-алкиламино]-1-фенил-1,2,4-триазолов
RU2277532C1 (ru) * 2005-02-15 2006-06-10 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" ГОУ ВПО ЮРГТУ (НПИ) Способ получения сульфонилпроизводных 3,5-диамино-1,2,4-триазола
RU2290398C2 (ru) * 2005-02-15 2006-12-27 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" ГОУ ВПО ЮРГТУ (НПИ) Способ получения 5-амино-3-n-r1-амино-1-r-1,2,4-триазолов
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
KR101194036B1 (ko) 2010-08-18 2012-10-24 한국에너지기술연구원 태양에너지를 활용한 유체가열장치
CA2968464A1 (en) 2014-11-25 2016-06-02 Bayer Pharma Aktiengesellschaft Substituted pyridobenzodiazepinone-derivatives and use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA835391A (en) * 1970-02-24 Schmidt Gunther 5,6-dihydro-5-oxo-11h-pyrido (2,3-6) (1,5) benzodiazepine compounds
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
NL131929C (enExample) * 1966-10-31
GB1262864A (en) * 1968-03-29 1972-02-09 Glaxo Lab Ltd Diazacarbazoles
DE3122670A1 (de) * 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820345A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820346A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
NZ234261A (en) 1992-11-25
IL94883A0 (en) 1991-04-15
ZA904991B (en) 1992-03-25
ES2063202T3 (es) 1995-01-01
HU206504B (en) 1992-11-30
KR910000727A (ko) 1991-01-30
AP9000188A0 (en) 1990-07-31
PT94521B (pt) 1997-02-28
HUT55017A (en) 1991-04-29
AU620724B2 (en) 1992-02-20
PT94521A (pt) 1991-02-08
OA09741A (en) 1993-11-30
CA2019812C (en) 2000-11-21
AU5792190A (en) 1991-01-03
NO174468C (enExample) 1994-05-18
IE902322A1 (en) 1991-01-16
DK0410148T3 (da) 1994-08-08
IL94883A (en) 1994-10-07
DE69007891T2 (de) 1994-08-25
AP189A (en) 1992-05-04
NO902851L (no) 1991-01-02
ATE103918T1 (de) 1994-04-15
CA2019812A1 (en) 1990-12-28
FI903225A0 (fi) 1990-06-27
FI92828C (fi) 1995-01-10
EP0410148A1 (en) 1991-01-30
DD295849A5 (de) 1991-11-14
NO902851D0 (no) 1990-06-27
JPH03115283A (ja) 1991-05-16
EP0410148B1 (en) 1994-04-06
DE69007891D1 (de) 1994-05-11
IE902322L (en) 1990-12-28
FI92828B (fi) 1994-09-30
HU904021D0 (en) 1990-12-28
RU2024522C1 (ru) 1994-12-15
KR0160285B1 (ko) 1998-12-01
JP2911967B2 (ja) 1999-06-28
NO174468B (no) 1994-01-31

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Legal Events

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MK9A Patent expired