IE63467B1 - Use of adamantane derivatives for the prevention and treatment of cerebral ischaemia - Google Patents
Use of adamantane derivatives for the prevention and treatment of cerebral ischaemiaInfo
- Publication number
- IE63467B1 IE63467B1 IE99690A IE99690A IE63467B1 IE 63467 B1 IE63467 B1 IE 63467B1 IE 99690 A IE99690 A IE 99690A IE 99690 A IE99690 A IE 99690A IE 63467 B1 IE63467 B1 IE 63467B1
- Authority
- IE
- Ireland
- Prior art keywords
- adamantane
- amino
- ethyl
- hydrogen
- use according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89106657A EP0392059B1 (de) | 1989-04-14 | 1989-04-14 | Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE900996L IE900996L (en) | 1990-10-14 |
| IE63467B1 true IE63467B1 (en) | 1995-04-19 |
Family
ID=8201228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE99690A IE63467B1 (en) | 1989-04-14 | 1990-03-16 | Use of adamantane derivatives for the prevention and treatment of cerebral ischaemia |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5061703A (enExample) |
| EP (1) | EP0392059B1 (enExample) |
| JP (1) | JP2821233B2 (enExample) |
| AT (1) | ATE94384T1 (enExample) |
| CA (1) | CA2014453C (enExample) |
| CH (1) | CH679208A5 (enExample) |
| DD (1) | DD293493A5 (enExample) |
| DE (2) | DE58905637D1 (enExample) |
| DK (1) | DK173356B1 (enExample) |
| ES (1) | ES2059602T3 (enExample) |
| HU (1) | HU215592B (enExample) |
| IE (1) | IE63467B1 (enExample) |
| LU (1) | LU90988I2 (enExample) |
| NL (1) | NL300107I1 (enExample) |
| PT (1) | PT93763B (enExample) |
| SE (1) | SE9001329L (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334618A (en) * | 1991-04-04 | 1994-08-02 | The Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5506231A (en) * | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5614560A (en) * | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| US5455279A (en) * | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
| WO1992017168A1 (en) * | 1991-04-04 | 1992-10-15 | The Children's Medical Center Corporation | Method of preventing nmda receptor-mediated neuronal damage |
| DE4225730C2 (de) * | 1992-08-04 | 2003-04-30 | Merz Pharma Gmbh & Co Kgaa | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
| IL112099A (en) * | 1993-12-23 | 1999-07-14 | Ortho Pharma Corp | N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them |
| DE19510189A1 (de) * | 1995-03-21 | 1996-09-26 | Hartmut Dr Goebel | Verwendung von Amantadin |
| DE19528388A1 (de) * | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
| US6057373A (en) * | 1997-05-22 | 2000-05-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists |
| US5866585A (en) * | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US6294583B1 (en) * | 1998-01-13 | 2001-09-25 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
| US5952389A (en) * | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
| GB9802225D0 (en) | 1998-02-02 | 1998-04-01 | Cerebrus Ltd | Chemical compounds |
| RU2147573C1 (ru) * | 1998-08-24 | 2000-04-20 | Волгоградский государственный технический университет | Способ получения адамант-1-иламина и его производных |
| US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| US7795468B2 (en) * | 2001-01-19 | 2010-09-14 | Chevron U.S.A. Inc. | Functionalized higher diamondoids |
| US20040248984A1 (en) * | 2001-08-29 | 2004-12-09 | Josef Krieglstein | Use of $g(b)-adrenoceptor agonists for the treatment of neurodegenerative diseases |
| DE10142176A1 (de) * | 2001-08-29 | 2003-03-27 | Eucro Europe Contract Res Gmbh | Verwendung einer Kombination aus ß-adrenergen Agonisten und NDMA-Antagonisten |
| AU2002333510A1 (en) | 2001-08-29 | 2003-03-18 | Eucro European Contract Research Gmbh And Co. Kg | Use of beta-adrenoceptor agonists for the treatment of neurodegenerative diseases |
| GB0202161D0 (en) * | 2002-01-30 | 2002-03-20 | Vernalis Res Ltd | Chemical compounds V |
| WO2004009062A2 (en) * | 2002-07-19 | 2004-01-29 | Khalid Iqbal | NMDA RECEPTOR ANTAGONISTS AND THEIR USE IN INHIBITING ABNORMAL HYPERPHOSPHORYLATION OF MICROTUBULE ASSOCIATED PROTEIN tau |
| TW200418446A (en) | 2002-10-24 | 2004-10-01 | Merz Pharma Gmbh & Co Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
| RU2246482C2 (ru) * | 2002-12-25 | 2005-02-20 | ООО "Циклан" | Способ получения гидрохлорида 1-амино-3,5-диметиладамантана |
| EP2260844A1 (en) * | 2003-05-27 | 2010-12-15 | Merz Pharma GmbH & Co. KGaA | Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders |
| CN100345819C (zh) * | 2003-07-01 | 2007-10-31 | 北京德众万全药物技术开发有限公司 | 一种取代的金刚烷胺类化合物或其盐的制备方法 |
| ITTO20030668A1 (it) * | 2003-09-02 | 2005-03-03 | Rotta Res Lab S P A O Ra Rottapharm | Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione. |
| CN1240668C (zh) * | 2003-09-10 | 2006-02-08 | 上海医药工业研究院 | 一种新的盐酸美金刚制备方法 |
| WO2005079779A1 (en) * | 2003-10-22 | 2005-09-01 | Merz Pharma Gmbh & Co. Kgaa | THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC Aß PEPTIDES IN AMYLOIDOPATHIES |
| AR046314A1 (es) | 2003-11-05 | 2005-11-30 | Merz Pharma Gmbh & Co Kgaa | Composiciones que comprenden ciclohexilaminas y aminoadamantanos |
| UY28650A1 (es) * | 2003-12-05 | 2005-02-28 | Forest Laboratories | Memantina para la prevencion o disminucion de la conducta suicida y para el tratamiento de la depresion mayor asociada con esta conducta |
| WO2005067908A2 (en) * | 2004-01-05 | 2005-07-28 | Merz Pharma Gmbh & Co. Kgaa | Memantine for the treatment of mild and mild-to-moderate alzheimer’s disease |
| EP1715843A1 (en) * | 2004-01-29 | 2006-11-02 | Neuromolecular Inc. | Combination of a nmda receptor antagonist and a mao-inhibitor or a gadph-inhibitor for the treatment of central nervous system-related conditions |
| US7456224B2 (en) * | 2004-04-05 | 2008-11-25 | Forest Laboratories Holdings, Ltd. | Method for treating autism |
| US20060002999A1 (en) | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
| JP5025468B2 (ja) * | 2004-06-17 | 2012-09-12 | メルツ・ファルマ・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト・アウフ・アクティーン | メマンチン又はネラメキサンの直接圧縮によって製造された、飲用に適した即効型錠剤 |
| EA011446B1 (ru) * | 2004-06-17 | 2009-02-27 | Форест Лэборэтериз, Инк. | Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением |
| TW200616608A (en) * | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| TW200621677A (en) * | 2004-09-21 | 2006-07-01 | Astellas Pharma Inc | Cyclic amine derivative or salt thereof |
| WO2006034465A1 (en) * | 2004-09-23 | 2006-03-30 | Merz Pharma Gmbh & Co. Kgaa | Memantine for the treatment of childhood behavioral disorders |
| CN100351225C (zh) * | 2004-10-28 | 2007-11-28 | 中国医学科学院医药生物技术研究所 | 一组金刚烷胺类衍生物及其合成方法和作为神经元损伤保护剂的应用 |
| CA2588295C (en) | 2004-11-23 | 2013-10-22 | Adamas Pharma, Llc | Method and composition for administering an nmda receptor antagonist to a subject |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| EP2623099A1 (en) | 2004-11-24 | 2013-08-07 | Neuromolecular Pharmaceuticals, Inc | Composition and method for treating neurological disease |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| WO2006076562A1 (en) * | 2005-01-11 | 2006-07-20 | Teva Pharmaceutical Fine Chemicals S.R.L. | Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride |
| ATE481096T1 (de) | 2005-04-06 | 2010-10-15 | Adamas Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen |
| ITMI20050833A1 (it) | 2005-05-10 | 2006-11-11 | A M S A S P A Anonima Materie Sintetiche Affini | Nuovo procedimento per la sintesi di aminoadamantani |
| EP1879849A1 (en) * | 2005-05-11 | 2008-01-23 | Dr. Reddy's Laboratories, Inc. | Process for preparing memantine |
| EP1898890A1 (en) * | 2005-06-16 | 2008-03-19 | Forest Laboratories, Inc. | Modified and immediate release memantine bead formulation |
| ES2528451T3 (es) | 2005-06-17 | 2015-02-10 | Apogee Biothechnology Corporation | Inhibidores de esfingosina cinasa |
| RU2309940C2 (ru) * | 2005-09-30 | 2007-11-10 | НПЦ "Фармзащита" | Способ получения 3,5-диметиладамантил-1-амина или его солей |
| US20070099947A1 (en) * | 2005-11-03 | 2007-05-03 | Alkermes, Inc. | Methods and compositions for the treatment of brain reward system disorders by combination therapy |
| ATE541827T1 (de) | 2006-02-21 | 2012-02-15 | Hexal Ag | Verfahren zur herstellung von adamantanaminen |
| DE102006009279A1 (de) * | 2006-03-01 | 2007-09-06 | Justus-Liebig-Universität Giessen | Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan |
| DE102006009278B4 (de) * | 2006-03-01 | 2010-06-02 | Justus-Liebig-Universität Giessen | Verfahren zur direkten Formamidierung oder Acetamidierung von Admantan und Admantanderivaten sowie deren Verwendung zur Herstellung von Aminoadmantanen |
| EP1999100A1 (en) | 2006-03-27 | 2008-12-10 | Teva Pharmaceutical Fine Chemicals S.R.L. | Process for preparing memantine hydrochloride substantially free of impurities |
| WO2008002594A2 (en) * | 2006-06-27 | 2008-01-03 | Neuroprotection For Life Corp. | Neuronal circuit-dependent neuroprotection by interaction between nicotinic receptors |
| EP2040676A2 (en) * | 2006-07-06 | 2009-04-01 | Forest Laboratories, Inc. | Orally dissolving formulations of memantine |
| ES2412384T3 (es) * | 2006-07-18 | 2013-07-11 | Astellas Pharma Inc. | Derivado de aminoindano o sal del mismo |
| MX2009001036A (es) | 2006-08-04 | 2009-04-23 | Merz Pharma Gmbh & Co Kgaa | Pirazolopirimidinas, proceso para su preparacion y su uso como medicina. |
| WO2008062472A2 (en) * | 2006-10-24 | 2008-05-29 | Cadila Healthcare Limited | Process for the preparation of memantine |
| WO2008051599A2 (en) | 2006-10-27 | 2008-05-02 | Medivation Neurology, Inc. | Combination therapies for treating alzheimer's disease using i. a. dimebon and dolepezil |
| WO2008063847A2 (en) * | 2006-11-03 | 2008-05-29 | Forest Laboratories Holdings Limited | Method for treating autism |
| GB0623897D0 (en) * | 2006-11-30 | 2007-01-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutical composition of memantine |
| US20080182908A1 (en) * | 2007-01-25 | 2008-07-31 | Vinita Umashankar Vyas | Pharmaceutical compositions comprising memantine |
| EP2085398A1 (en) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| EP2090576A1 (en) | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators |
| US8648059B2 (en) * | 2008-03-13 | 2014-02-11 | The Regents Of The University Of California | Use of epicatechin and derivatives and salts thereof for cardiac protection of ischemic myocardium and to ameliorate adverse cardiac remodeling |
| EP2103597A1 (en) | 2008-03-20 | 2009-09-23 | Merz Pharma GmbH & Co.KGaA | Process for the manufacture of memantine and intermediate product |
| ES2507085T3 (es) * | 2008-03-20 | 2014-10-14 | Merz Pharma Gmbh & Co. Kgaa | Proceso para la fabricación de Memantina y producto intermedio |
| KR100998525B1 (ko) | 2008-03-28 | 2010-12-07 | 나노다이아몬드 주식회사 | 아밀로이드 올리고머 독성 억제제로서의 아다만탄 유도체 |
| WO2009151498A2 (en) * | 2008-03-28 | 2009-12-17 | Forest Laboratories Holdings Limited | Memantine formulations |
| EP2288345B1 (en) | 2008-04-18 | 2015-06-10 | University College Dublin National University Of Ireland, Dublin | Psycho-pharmaceuticals |
| EP2111858A1 (en) | 2008-04-25 | 2009-10-28 | EPFL Ecole Polytechnique Fédérale de Lausanne | Novel treatment for alzheimer's disease |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| EP2138173A1 (en) | 2008-06-26 | 2009-12-30 | Merz Pharma GmbH & Co.KGaA | Pharmaceutical compositions comprising aminoadamantane derivatives |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| WO2010112221A1 (en) | 2009-04-03 | 2010-10-07 | Synthon B.V. | Pharmaceutical compositions comprising memantine |
| WO2011015265A2 (en) | 2009-08-04 | 2011-02-10 | Merck Patent Gmbh | Electronic devices comprising multi cyclic hydrocarbons |
| TW201116532A (en) | 2009-08-05 | 2011-05-16 | Merz Pharma Gmbh & Co Kgaa | Metabotropic glutamate receptor modulators |
| CA2994873A1 (en) | 2009-12-02 | 2011-06-09 | Adamas Pharma, Llc | Amantadine compositions and methods of use |
| ES2758554T3 (es) | 2009-12-08 | 2020-05-05 | Univ Case Western Reserve | Aminoácidos gama para tratamiento de trastornos oculares |
| US20110251239A1 (en) | 2010-04-07 | 2011-10-13 | Eisai Inc. | Combination therapy for the treatment of dementia |
| JP5562716B2 (ja) * | 2010-05-12 | 2014-07-30 | 花王株式会社 | 電位依存性カチオンチャネル抑制剤 |
| PL2578212T3 (pl) | 2010-05-24 | 2017-01-31 | Farmalider Sa | Związek hamujący aktywację enzymu Erk 1/2 do zastosowania w leczeniu chorób neurodegeneracyjnych |
| FR2962335B1 (fr) | 2010-07-12 | 2013-01-18 | Cll Pharma | Utilisation du nonapeptide pat dans le traitement et la prevention des maladies neurodegeneratives |
| WO2012048871A1 (en) | 2010-10-12 | 2012-04-19 | Merz Pharma Gmbh & Co. Kgaa | Memantine for improving cognitive performance in subjects |
| AR083475A1 (es) | 2010-10-18 | 2013-02-27 | Merz Pharma Gmbh & Co Kgaa | Moduladores de receptores de glutamato metabotropicos |
| MX2013004760A (es) | 2010-10-29 | 2013-07-02 | Merz Pharma Gmbh & Co Kgaa | Derivados de indol y proceso para su preparacion. |
| EP3034079B1 (en) | 2010-11-15 | 2018-01-10 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| AR084516A1 (es) | 2010-12-22 | 2013-05-22 | Merz Pharma Gmbh & Co Kgaa | Moduladores de receptores de glutamato metabotropicos |
| AR084515A1 (es) | 2010-12-22 | 2013-05-22 | Merz Pharma Gmbh & Co Kgaa | Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras |
| US20140004189A1 (en) | 2011-01-25 | 2014-01-02 | Cadila Healthcare Limited | Modified release pharmaceutical compositions memantine |
| CN102241678B (zh) | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| WO2012152854A1 (en) | 2011-05-12 | 2012-11-15 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| WO2012172093A1 (en) | 2011-06-17 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Dihydroindolizine derivate as metabotropic glutamate receptor modulators |
| EP2650284A1 (en) | 2012-04-10 | 2013-10-16 | Merz Pharma GmbH & Co. KGaA | Heterocyclic derivatives as metabotropic glutamate receptor modulators |
| KR20140146192A (ko) | 2012-04-14 | 2014-12-24 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| RU2488388C1 (ru) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
| WO2014015047A1 (en) | 2012-07-17 | 2014-01-23 | The General Hospital Corporation | Compositions and methods to treat neurodegenerative diseases |
| UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| NZ760341A (en) | 2013-12-20 | 2021-12-24 | Agenebio Inc | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| EP3102186B1 (en) | 2014-02-04 | 2021-01-27 | Forest Laboratories Holdings Limited | Donepezil compositions and method of treating alzheimer's disease |
| IL234638A0 (en) | 2014-09-14 | 2014-12-02 | Yeda Res & Dev | NMDA receptor antagonists for the treatment of Gaucher disease |
| MX392119B (es) | 2015-06-19 | 2025-03-11 | Agenebio Inc | Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo |
| US10583171B2 (en) | 2015-11-30 | 2020-03-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | NMDAR antagonists for the treatment of diseases associated with angiogenesis |
| US10966936B2 (en) | 2015-12-30 | 2021-04-06 | Corium, Inc. | Systems comprising a composite backing and methods for long term transdermal administration |
| CA3011538A1 (en) | 2016-01-18 | 2017-07-27 | Arisan Therapeutics | Adamantane derivatives for the treatment of filovirus infection |
| WO2017223402A1 (en) | 2016-06-23 | 2017-12-28 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| EP3490544A1 (en) | 2016-07-27 | 2019-06-05 | Corium International, Inc. | Memantine transdermal delivery systems |
| WO2018022814A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
| CN116270551A (zh) | 2016-07-27 | 2023-06-23 | 考里安有限责任公司 | 通过盐至中性药物原位转化的组合物、透皮贴剂及应用 |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US10369187B2 (en) | 2017-02-09 | 2019-08-06 | Vanderbilt University | Peptide regulators of JNK family kinases |
| WO2019018185A1 (en) | 2017-07-15 | 2019-01-24 | Arisan Therapeutics Inc. | ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS |
| US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| CN112601749B (zh) | 2018-06-19 | 2024-03-26 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物,组合物和方法 |
| EP3890714A4 (en) | 2018-12-05 | 2022-02-23 | Regents of the University of California | ANTI-CANCER ACTIVITY OF ADAMANTAN DERIVATIVES |
| BR112021024054A2 (pt) | 2019-05-31 | 2022-01-11 | Tecnimede Sociedade Tecnico Medicinal Sa | Composições farmacêuticas de combinação de dose fixa de liberação imediata, seus métodos e usos. |
| EP4005565A1 (en) | 2020-11-30 | 2022-06-01 | Merz Pharmaceuticals GmbH | Novel uses of adamantane derivatives |
| CN119095622A (zh) | 2022-02-08 | 2024-12-06 | 菲克雷特·萨欣 | Nmdar拮抗剂通过提高20s蛋白酶体活性来预防老化和老化相关病况和疾病 |
| CN120584115A (zh) | 2022-08-19 | 2025-09-02 | 艾吉因生物股份有限公司 | 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450761A (en) * | 1967-03-30 | 1969-06-17 | Sun Oil Co | 1-aminoethyldimethyladamantane |
| US4748154A (en) * | 1985-12-24 | 1988-05-31 | Takeda Chemical Industries, Ltd. | Peptide derivatives, their production and use |
| IT1205042B (it) * | 1987-05-28 | 1989-03-10 | Crinos Industria Farmaco | Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer |
-
1989
- 1989-04-14 ES ES89106657T patent/ES2059602T3/es not_active Expired - Lifetime
- 1989-04-14 EP EP89106657A patent/EP0392059B1/de not_active Expired - Lifetime
- 1989-04-14 DE DE89106657T patent/DE58905637D1/de not_active Expired - Lifetime
- 1989-04-14 AT AT89106657T patent/ATE94384T1/de active
- 1989-04-14 DE DE2002199048 patent/DE10299048I2/de active Active
-
1990
- 1990-03-16 IE IE99690A patent/IE63467B1/en not_active IP Right Cessation
- 1990-04-10 CH CH1539/90A patent/CH679208A5/de not_active IP Right Cessation
- 1990-04-11 SE SE9001329A patent/SE9001329L/xx not_active Application Discontinuation
- 1990-04-11 DK DK199000916A patent/DK173356B1/da not_active IP Right Cessation
- 1990-04-11 US US07/508,109 patent/US5061703A/en not_active Expired - Lifetime
- 1990-04-11 CA CA002014453A patent/CA2014453C/en not_active Expired - Lifetime
- 1990-04-12 PT PT93763A patent/PT93763B/pt not_active IP Right Cessation
- 1990-04-12 DD DD90339741A patent/DD293493A5/de not_active IP Right Cessation
- 1990-04-13 JP JP2099117A patent/JP2821233B2/ja not_active Expired - Lifetime
- 1990-04-13 HU HU902434A patent/HU215592B/hu unknown
-
2002
- 2002-11-13 LU LU90988C patent/LU90988I2/fr unknown
- 2002-11-14 NL NL300107C patent/NL300107I1/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE9001329D0 (sv) | 1990-04-11 |
| US5061703A (en) | 1991-10-29 |
| CH679208A5 (enExample) | 1992-01-15 |
| IE900996L (en) | 1990-10-14 |
| JPH02292214A (ja) | 1990-12-03 |
| CA2014453C (en) | 2000-03-28 |
| DE10299048I1 (de) | 2003-03-27 |
| DK91690D0 (da) | 1990-04-11 |
| PT93763B (pt) | 1996-04-30 |
| EP0392059A1 (de) | 1990-10-17 |
| HU902434D0 (en) | 1990-08-28 |
| DE10299048I2 (de) | 2006-07-13 |
| SE9001329L (sv) | 1990-10-15 |
| ATE94384T1 (de) | 1993-10-15 |
| HUT58200A (en) | 1992-02-28 |
| DK91690A (da) | 1990-10-15 |
| DE58905637D1 (de) | 1993-10-21 |
| DK173356B1 (da) | 2000-08-07 |
| LU90988I2 (fr) | 2003-01-13 |
| PT93763A (pt) | 1990-11-20 |
| JP2821233B2 (ja) | 1998-11-05 |
| EP0392059B1 (de) | 1993-09-15 |
| CA2014453A1 (en) | 1990-10-14 |
| NL300107I2 (nl) | 2003-02-03 |
| NL300107I1 (nl) | 2003-02-03 |
| HU215592B (hu) | 1999-01-28 |
| DD293493A5 (de) | 1991-09-05 |
| ES2059602T3 (es) | 1994-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE63467B1 (en) | Use of adamantane derivatives for the prevention and treatment of cerebral ischaemia | |
| HU226110B1 (en) | 1-amino-alkylcyclohexane nmda receptor antagonists, pharmaceutical compositions containing and their use | |
| LT4455B (lt) | N-propargil-1-aminoindano r-entantiomero, jo druskų ir jo kompozicijų panaudojimas | |
| HU226138B1 (en) | R-enantiomer of n-propargyl-1-aminoindan, salts, compositions and uses thereof | |
| JP2003523989A (ja) | 治療剤としてのアミノアダマンタン誘導体 | |
| JPH06509335A (ja) | アシルメルカプトアルカノイルジペプチド類、その製造方法及びその治療学的使用 | |
| JP2003521470A (ja) | ベンラファキシンの誘導体とその調製および使用方法 | |
| EP1749522A2 (en) | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases | |
| EP0284621A1 (en) | PSYCHOSTIMULATING AGENT. | |
| KR100581451B1 (ko) | 1,7,7-트리메틸-바이시클로[2.2.1]헵탄 유도체 | |
| CN111285923B (zh) | 一种psd-95抑制剂 | |
| US3341593A (en) | 1-p-hydroxyphenyl-2-(beta-3', 5'-dihydroxyphenyl-beta-hydroxy)-ethylamino-propanes | |
| EP0694299B1 (en) | The use of( a) bicycloheptane derivative(s) | |
| CN107753469B (zh) | Ndga类似物在制备抗氧化药物中的应用 | |
| US6498196B1 (en) | Compounds useful in pain management | |
| AU2007286651A1 (en) | 3-(3-indolyl) propionic acid calcium salt and method of making 3-(3-indolyl) propionic acid free acid therefrom | |
| US5652270A (en) | Pharmaceutical compositions containing bicycloheptane ether amines and a process for the preparation thereof | |
| CN101712658A (zh) | 1-丁基-2-羟基芳烷哌嗪衍生物及作为抗抑郁剂应用 | |
| EP1848426B1 (en) | Tricyclic cytoprotective compounds | |
| US5955493A (en) | Thiamorphinans with neuroprotective activity | |
| US3789070A (en) | Prophylaxis and treatment of cardiac 3,4,5-trialkoxyphenylalkanoic acids and salts thereof | |
| US6083992A (en) | Use of 2-methylamino-2-phenylcyclohexanone for the treatment of bacterial infections | |
| CA3210043A1 (en) | Therapeutic compounds and methods of use thereof | |
| KR830001683B1 (ko) | 4급 암모늄 부정맥 치료제의 제조방법 | |
| EP2093218A1 (en) | Arylalkyl substituted imidazolidinones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Request for grant of supplementary protection certificate |
Free format text: SPC030/2002: 20021106, EXPIRES: 20100316 Spc suppl protection certif: SPC030/2002 Filing date: 20021106 Expiry date: 20100316 |
|
| SPCG | Supplementary protection certificate granted |
Free format text: SPC030/2002: 20040930, EXPIRES: 20150315 Spc suppl protection certif: SPC030/2002 Filing date: 20040930 Expiry date: 20150315 |
|
| MK9A | Patent expired | ||
| SPCI | Supplementary protection certificate declared invalid |
Free format text: PRODUCT NAME: MEMANTINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, ESPECIALLY THE HYDROCHLORIDE; REGISTRATION NO/DATE: EU/1/02/219/001-006 20020515 Spc suppl protection certif: 2002/030 Filing date: 20021106 Effective date: 20120228 |