IE58301B1 - Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents - Google Patents

Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents

Info

Publication number
IE58301B1
IE58301B1 IE124283A IE124283A IE58301B1 IE 58301 B1 IE58301 B1 IE 58301B1 IE 124283 A IE124283 A IE 124283A IE 124283 A IE124283 A IE 124283A IE 58301 B1 IE58301 B1 IE 58301B1
Authority
IE
Ireland
Prior art keywords
group
tetradehydro
methyl
free
carbaprostaglandin
Prior art date
Application number
IE124283A
Other languages
English (en)
Other versions
IE831242L (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IE831242L publication Critical patent/IE831242L/en
Publication of IE58301B1 publication Critical patent/IE58301B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Road Signs Or Road Markings (AREA)
IE124283A 1982-05-28 1983-05-26 Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents IE58301B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823221193 DE3221193A1 (de) 1982-05-28 1982-05-28 Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
IE831242L IE831242L (en) 1983-11-28
IE58301B1 true IE58301B1 (en) 1993-10-06

Family

ID=6165375

Family Applications (1)

Application Number Title Priority Date Filing Date
IE124283A IE58301B1 (en) 1982-05-28 1983-05-26 Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents

Country Status (18)

Country Link
US (1) US4618626A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0099850B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS58225041A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE70531T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU567877B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1246557A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS240962B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD209806A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3221193A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK207383A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES522632A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI831890A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR77466B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU190722B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE58301B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL68715A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO831908L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA833883B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4876279A (en) * 1986-05-05 1989-10-24 Merck & Co., Inc. Antihypercholesterolemic compounds
GB2192395B (en) * 1986-07-08 1990-11-14 Kotobuki Seiyaku Co Ltd Carbacyclin derivatives
US4730078A (en) * 1987-05-13 1988-03-08 G. D. Searle & Co. Allenic prostacyclins
DE69019431T2 (de) * 1989-07-27 1995-09-14 Ueno Seiyaku Oyo Kenkyujo Kk Verwendung von 15-Keto-Prostansäure-Derivaten zur Herstellung eines Medikaments für die Verbesserung der Ausscheidung des Kaliumions.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979440A (en) * 1974-08-14 1976-09-07 The Upjohn Company Phenacyl-type esters of phenyl-substituted PGE-type compounds
US4238414A (en) * 1978-02-13 1980-12-09 The Upjohn Company 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE3104044A1 (de) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GR77976B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1982-03-12 1984-09-25 Schering Ag

Also Published As

Publication number Publication date
CA1246557A (en) 1988-12-13
DE3382479D1 (de) 1992-01-30
ES8402809A1 (es) 1984-03-01
CS240962B2 (en) 1986-03-13
FI831890L (fi) 1983-11-29
EP0099850B1 (en) 1991-12-18
JPS58225041A (ja) 1983-12-27
DK207383D0 (da) 1983-05-10
US4618626A (en) 1986-10-21
HU190722B (en) 1986-10-28
ZA833883B (en) 1984-04-25
ES522632A0 (es) 1984-03-01
EP0099850A1 (en) 1984-02-01
AU1481383A (en) 1983-12-01
GR77466B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-09-24
IL68715A0 (en) 1983-09-30
AU567877B2 (en) 1987-12-10
NO831908L (no) 1983-11-29
FI831890A7 (fi) 1983-11-29
IE831242L (en) 1983-11-28
DD209806A5 (de) 1984-05-23
FI831890A0 (fi) 1983-05-26
DE3221193A1 (de) 1983-12-01
CS369883A2 (en) 1985-06-13
ATE70531T1 (de) 1992-01-15
DK207383A (da) 1983-11-29
JPH0355461B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-08-23

Similar Documents

Publication Publication Date Title
US4692464A (en) Novel prostacyclin derivatives and a process for the preparation thereof
US4708963A (en) Novel carbacyclins, their preparation and use
US4886788A (en) Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents
US4364951A (en) Prostacyclins and use as medicinal agents
US4552875A (en) Novel carbacyclinamides, their preparation and use as medicinal agents
IE57233B1 (en) Novel carbacyclins,process for their manufacture and their use as medicaments
EP0099850B1 (en) Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents
US4894391A (en) Novel prostacyclin derivatives, process for the preparation thereof, and use thereof as medicinal agents
US4315013A (en) Certain pyrrole analogs of prostacyclin derivatives
JPH0446256B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
US4532236A (en) Certain prostacyclins and their blood-pressure-lowering and thrombocyte-aggregation-inhibiting compositions and methods
US5157042A (en) 3-oxa-5-fluoro-carbacyclins, their preparation and use as medicinal agents
US4364950A (en) 5-Cyano-prostacyclin derivatives and use as medicines
US4721729A (en) Novel carbacyclins, process for the preparation thereof, and their use as medicinal agents
CS226440B2 (en) Method of preparing 7-oxoprostacycline derivatives
US5190964A (en) 5-fluorocarbacyclins, their preparation and pharmaceutical use
US4827017A (en) Novel carbacyclins, processes for their production and their use as medicinal agents
US5190973A (en) 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals
JPH0510330B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Legal Events

Date Code Title Description
MM4A Patent lapsed