IE52934B1 - 7a-alkoxycarbonyl-15b-, 16b-methylene-4-androstenes, process for the preparation thereof, and use thereof as medicinal agents - Google Patents
7a-alkoxycarbonyl-15b-, 16b-methylene-4-androstenes, process for the preparation thereof, and use thereof as medicinal agentsInfo
- Publication number
- IE52934B1 IE52934B1 IE669/82A IE66982A IE52934B1 IE 52934 B1 IE52934 B1 IE 52934B1 IE 669/82 A IE669/82 A IE 669/82A IE 66982 A IE66982 A IE 66982A IE 52934 B1 IE52934 B1 IE 52934B1
- Authority
- IE
- Ireland
- Prior art keywords
- methylene
- oxo
- hydroxy
- bond
- methoxycarbonyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 13
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 4
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- 239000001257 hydrogen Substances 0.000 claims abstract description 4
- 239000011591 potassium Substances 0.000 claims abstract description 4
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 4
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000005907 alkyl ester group Chemical group 0.000 claims description 3
- BWILYWWHXDGKQA-UHFFFAOYSA-M potassium propanoate Chemical compound [K+].CCC([O-])=O BWILYWWHXDGKQA-UHFFFAOYSA-M 0.000 claims description 3
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims 4
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
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- 230000000699 topical effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813111951 DE3111951A1 (de) | 1981-03-23 | 1981-03-23 | 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE820669L IE820669L (en) | 1982-09-23 |
| IE52934B1 true IE52934B1 (en) | 1988-04-13 |
Family
ID=6128363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE669/82A IE52934B1 (en) | 1981-03-23 | 1982-03-23 | 7a-alkoxycarbonyl-15b-, 16b-methylene-4-androstenes, process for the preparation thereof, and use thereof as medicinal agents |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4450107A (en, 2012) |
| EP (1) | EP0061418B1 (en, 2012) |
| JP (1) | JPS57177000A (en, 2012) |
| AT (1) | ATE15051T1 (en, 2012) |
| AU (1) | AU555657B2 (en, 2012) |
| CA (1) | CA1202615A (en, 2012) |
| DD (1) | DD202440A5 (en, 2012) |
| DE (2) | DE3111951A1 (en, 2012) |
| DK (1) | DK91282A (en, 2012) |
| HU (1) | HU184516B (en, 2012) |
| IE (1) | IE52934B1 (en, 2012) |
| IL (1) | IL65316A (en, 2012) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| DE3326013A1 (de) * | 1983-07-15 | 1985-01-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-methylen-17(alpha)-pregna-4,6-dien-21-carbonsaeuresalze, diese enthaltende pharmazeutische praeparate sowie verfahren zu deren herstellung |
| ATE51233T1 (de) * | 1983-08-17 | 1990-04-15 | Schering Ag | 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
| DE3330084A1 (de) * | 1983-08-17 | 1985-03-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3414508A1 (de) * | 1984-04-13 | 1985-10-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen |
| ES2053091T3 (es) * | 1989-08-04 | 1994-07-16 | Schering Ag | 16alfa,17beta-metilen-estra-4,9-dien-3-onas sustituidas en 11beta. |
| CN101720321B (zh) * | 2007-03-07 | 2012-12-05 | 詹森药业有限公司 | 作为选择性受体调节剂的甾族衍生物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787940A (fr) * | 1971-08-25 | 1973-02-26 | Searle & Co | Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation |
| GB1368006A (en) * | 1972-08-24 | 1974-09-25 | Searle & Co | 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone |
| CH631462A5 (de) * | 1976-03-05 | 1982-08-13 | Schering Ag | Verfahren zur herstellung von neuen steroiden der androstan- oder oestranreihe. |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4069219A (en) * | 1976-12-27 | 1978-01-17 | G. D. Searle & Co. | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters |
| DE2922500A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
-
1981
- 1981-03-23 DE DE19813111951 patent/DE3111951A1/de not_active Withdrawn
-
1982
- 1982-03-03 DK DK91282A patent/DK91282A/da not_active Application Discontinuation
- 1982-03-19 EP EP82730038A patent/EP0061418B1/de not_active Expired
- 1982-03-19 AT AT82730038T patent/ATE15051T1/de not_active IP Right Cessation
- 1982-03-19 DE DE8282730038T patent/DE3265533D1/de not_active Expired
- 1982-03-19 DD DD82238302A patent/DD202440A5/de unknown
- 1982-03-22 HU HU82851A patent/HU184516B/hu not_active IP Right Cessation
- 1982-03-22 CA CA000399045A patent/CA1202615A/en not_active Expired
- 1982-03-23 US US06/361,164 patent/US4450107A/en not_active Expired - Fee Related
- 1982-03-23 IE IE669/82A patent/IE52934B1/en unknown
- 1982-03-23 IL IL65316A patent/IL65316A/xx unknown
- 1982-03-23 AU AU81810/82A patent/AU555657B2/en not_active Ceased
- 1982-03-23 JP JP57046179A patent/JPS57177000A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK91282A (da) | 1982-09-24 |
| DE3111951A1 (de) | 1982-09-30 |
| CA1202615A (en) | 1986-04-01 |
| IL65316A (en) | 1985-05-31 |
| DD202440A5 (de) | 1983-09-14 |
| US4450107A (en) | 1984-05-22 |
| AU8181082A (en) | 1982-09-30 |
| EP0061418A1 (de) | 1982-09-29 |
| DE3265533D1 (en) | 1985-09-26 |
| JPH0411558B2 (en, 2012) | 1992-02-28 |
| IE820669L (en) | 1982-09-23 |
| EP0061418B1 (de) | 1985-08-21 |
| IL65316A0 (en) | 1982-05-31 |
| HU184516B (en) | 1984-09-28 |
| JPS57177000A (en) | 1982-10-30 |
| ATE15051T1 (de) | 1985-09-15 |
| AU555657B2 (en) | 1986-10-02 |
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