AU555657B2 - 7alpha-alkoxycarbonyl-15beta, 16beta-methylene-4- androstenes - Google Patents
7alpha-alkoxycarbonyl-15beta, 16beta-methylene-4- androstenesInfo
- Publication number
- AU555657B2 AU555657B2 AU81810/82A AU8181082A AU555657B2 AU 555657 B2 AU555657 B2 AU 555657B2 AU 81810/82 A AU81810/82 A AU 81810/82A AU 8181082 A AU8181082 A AU 8181082A AU 555657 B2 AU555657 B2 AU 555657B2
- Authority
- AU
- Australia
- Prior art keywords
- image
- alkoxycarbonyl
- methylene
- bond
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- ZESRJSPZRDMNHY-YFWFAHHUSA-N 11-deoxycorticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 ZESRJSPZRDMNHY-YFWFAHHUSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002170 aldosterone antagonist Substances 0.000 abstract 1
- 229940083712 aldosterone antagonist Drugs 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- ZESRJSPZRDMNHY-UHFFFAOYSA-N de-oxy corticosterone Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 ZESRJSPZRDMNHY-UHFFFAOYSA-N 0.000 abstract 1
- 229940119740 deoxycorticosterone Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000029142 excretion Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE31119514 | 1981-03-23 | ||
| DE19813111951 DE3111951A1 (de) | 1981-03-23 | 1981-03-23 | 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8181082A AU8181082A (en) | 1982-09-30 |
| AU555657B2 true AU555657B2 (en) | 1986-10-02 |
Family
ID=6128363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU81810/82A Ceased AU555657B2 (en) | 1981-03-23 | 1982-03-23 | 7alpha-alkoxycarbonyl-15beta, 16beta-methylene-4- androstenes |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4450107A (en, 2012) |
| EP (1) | EP0061418B1 (en, 2012) |
| JP (1) | JPS57177000A (en, 2012) |
| AT (1) | ATE15051T1 (en, 2012) |
| AU (1) | AU555657B2 (en, 2012) |
| CA (1) | CA1202615A (en, 2012) |
| DD (1) | DD202440A5 (en, 2012) |
| DE (2) | DE3111951A1 (en, 2012) |
| DK (1) | DK91282A (en, 2012) |
| HU (1) | HU184516B (en, 2012) |
| IE (1) | IE52934B1 (en, 2012) |
| IL (1) | IL65316A (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU578034B2 (en) * | 1983-08-17 | 1988-10-13 | Schering Aktiengesellschaft | 7 alpha substituted 3-oxo-17alpha-pregn-4-ene -21,17 carbolactones |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| DE3326013A1 (de) * | 1983-07-15 | 1985-01-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-methylen-17(alpha)-pregna-4,6-dien-21-carbonsaeuresalze, diese enthaltende pharmazeutische praeparate sowie verfahren zu deren herstellung |
| DE3330084A1 (de) * | 1983-08-17 | 1985-03-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3414508A1 (de) * | 1984-04-13 | 1985-10-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen |
| ES2053091T3 (es) * | 1989-08-04 | 1994-07-16 | Schering Ag | 16alfa,17beta-metilen-estra-4,9-dien-3-onas sustituidas en 11beta. |
| CN101720321B (zh) * | 2007-03-07 | 2012-12-05 | 詹森药业有限公司 | 作为选择性受体调节剂的甾族衍生物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787940A (fr) * | 1971-08-25 | 1973-02-26 | Searle & Co | Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation |
| GB1368006A (en) * | 1972-08-24 | 1974-09-25 | Searle & Co | 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone |
| CH631462A5 (de) * | 1976-03-05 | 1982-08-13 | Schering Ag | Verfahren zur herstellung von neuen steroiden der androstan- oder oestranreihe. |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4069219A (en) * | 1976-12-27 | 1978-01-17 | G. D. Searle & Co. | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters |
| DE2922500A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
-
1981
- 1981-03-23 DE DE19813111951 patent/DE3111951A1/de not_active Withdrawn
-
1982
- 1982-03-03 DK DK91282A patent/DK91282A/da not_active Application Discontinuation
- 1982-03-19 EP EP82730038A patent/EP0061418B1/de not_active Expired
- 1982-03-19 AT AT82730038T patent/ATE15051T1/de not_active IP Right Cessation
- 1982-03-19 DE DE8282730038T patent/DE3265533D1/de not_active Expired
- 1982-03-19 DD DD82238302A patent/DD202440A5/de unknown
- 1982-03-22 HU HU82851A patent/HU184516B/hu not_active IP Right Cessation
- 1982-03-22 CA CA000399045A patent/CA1202615A/en not_active Expired
- 1982-03-23 US US06/361,164 patent/US4450107A/en not_active Expired - Fee Related
- 1982-03-23 IE IE669/82A patent/IE52934B1/en unknown
- 1982-03-23 IL IL65316A patent/IL65316A/xx unknown
- 1982-03-23 AU AU81810/82A patent/AU555657B2/en not_active Ceased
- 1982-03-23 JP JP57046179A patent/JPS57177000A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU578034B2 (en) * | 1983-08-17 | 1988-10-13 | Schering Aktiengesellschaft | 7 alpha substituted 3-oxo-17alpha-pregn-4-ene -21,17 carbolactones |
Also Published As
| Publication number | Publication date |
|---|---|
| DK91282A (da) | 1982-09-24 |
| DE3111951A1 (de) | 1982-09-30 |
| CA1202615A (en) | 1986-04-01 |
| IL65316A (en) | 1985-05-31 |
| DD202440A5 (de) | 1983-09-14 |
| US4450107A (en) | 1984-05-22 |
| AU8181082A (en) | 1982-09-30 |
| EP0061418A1 (de) | 1982-09-29 |
| DE3265533D1 (en) | 1985-09-26 |
| JPH0411558B2 (en, 2012) | 1992-02-28 |
| IE820669L (en) | 1982-09-23 |
| EP0061418B1 (de) | 1985-08-21 |
| IL65316A0 (en) | 1982-05-31 |
| HU184516B (en) | 1984-09-28 |
| JPS57177000A (en) | 1982-10-30 |
| IE52934B1 (en) | 1988-04-13 |
| ATE15051T1 (de) | 1985-09-15 |
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