IE50892B1 - Process for preparing insulin esters - Google Patents

Process for preparing insulin esters

Info

Publication number
IE50892B1
IE50892B1 IE251/81A IE25181A IE50892B1 IE 50892 B1 IE50892 B1 IE 50892B1 IE 251/81 A IE251/81 A IE 251/81A IE 25181 A IE25181 A IE 25181A IE 50892 B1 IE50892 B1 IE 50892B1
Authority
IE
Ireland
Prior art keywords
gly
process according
insulin
ala
leu
Prior art date
Application number
IE251/81A
Other languages
English (en)
Other versions
IE810251L (en
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK57480A external-priority patent/DK147109C/da
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of IE810251L publication Critical patent/IE810251L/xx
Publication of IE50892B1 publication Critical patent/IE50892B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IE251/81A 1980-02-11 1981-02-10 Process for preparing insulin esters IE50892B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK57480A DK147109C (da) 1980-02-11 1980-02-11 Fremgangsmaade til fremstilling af humant insulin eller humane insulinestere eller et salt eller kompleks deraf
DK366280 1980-08-28

Publications (2)

Publication Number Publication Date
IE810251L IE810251L (en) 1981-08-11
IE50892B1 true IE50892B1 (en) 1986-08-06

Family

ID=26064239

Family Applications (1)

Application Number Title Priority Date Filing Date
IE251/81A IE50892B1 (en) 1980-02-11 1981-02-10 Process for preparing insulin esters

Country Status (4)

Country Link
US (1) US4343898A (enExample)
AT (1) AT399881B (enExample)
FR (1) FR2475542B1 (enExample)
IE (1) IE50892B1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
CA1174623A (en) * 1981-09-15 1984-09-18 Finn H. Andresen Process for preparing human insulin or b-30 esters thereof
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
US4528134A (en) * 1982-12-27 1985-07-09 University Of Tn Research Corporation Method of separating A14 -125 I-insulin from heterogeneously labeled insulin molecules for biological studies
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
US5512459A (en) * 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
EA200000453A1 (ru) 1997-10-24 2000-10-30 Эли Лилли Энд Компани Композиции нерастворимого инсулина
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
BR0016860A (pt) 1999-12-29 2002-10-01 Novo Nordisk As Precursor da insulina ou análogo de precursor de insulina, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, e, processos para fabricar um precursor da insulina ou análogo de precursor de insulina, e, insulina ou um análogo de insulina
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds
AU2002342597A1 (en) 2001-11-19 2003-06-10 Novo Nordisk A/S Process for preparing insulin compounds
UA46667C2 (en) * 2001-12-29 2006-01-16 Omakooe Ltd Liability Company Method for preparing semisynthetic human insulin
DE602005014962D1 (de) * 2004-03-12 2009-07-30 Biodel Inc Insulinzusammensetzungen mit verbesserter wirkstoffabsorption
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
CN101166545B (zh) 2005-05-13 2011-06-15 伊莱利利公司 Glp-1聚乙二醇化的化合物
BRPI0520362B1 (pt) * 2005-07-08 2017-10-17 Biocon Limited Preparation of insulin conjugates
US8084420B2 (en) * 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7713929B2 (en) * 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
WO2007121256A2 (en) * 2006-04-12 2007-10-25 Biodel, Inc. Rapid acting and long acting insulin combination formulations
MX2008013304A (es) 2006-04-20 2008-10-27 Amgen Inc Compuestos de peptido 1 tipo glucagon.
CA2711561A1 (en) * 2008-01-04 2009-07-16 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
JP5698977B2 (ja) 2008-07-30 2015-04-08 武田薬品工業株式会社 メタスチン誘導体およびその用途
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2011031662A1 (en) 2009-09-08 2011-03-17 Kent Stephen B H Ester insulin
JP5973427B2 (ja) 2010-06-23 2016-08-23 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体
CN102933599A (zh) 2010-06-23 2013-02-13 诺沃—诺迪斯克有限公司 包含额外的二硫键的人胰岛素
WO2011161125A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
JP2014509603A (ja) 2011-03-15 2014-04-21 ノヴォ ノルディスク アー／エス システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体
US9260503B2 (en) 2011-06-15 2016-02-16 Novo Nordisk A/S Multi-substituted insulins
CA2890048C (en) 2012-12-03 2022-05-03 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
US20160115216A1 (en) 2013-06-07 2016-04-28 Novo Nordisk A/S Method for Making Mature Insulin Polypeptides
UA119762C2 (uk) * 2013-12-23 2019-08-12 Біокон Ресерч Лімітед Спосіб отримання метилового ефіру інсуліну людини
AU2018317810A1 (en) 2017-08-17 2020-03-19 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
WO2023144240A1 (en) 2022-01-26 2023-08-03 Novo Nordisk Research Centre Oxford Limited Glucose sensitive insulin derivatives and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin

Also Published As

Publication number Publication date
US4343898A (en) 1982-08-10
ATA63681A (de) 1994-12-15
IE810251L (en) 1981-08-11
AT399881B (de) 1995-08-25
FR2475542A1 (enExample) 1981-08-14
FR2475542B1 (enExample) 1988-09-09

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Legal Events

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