IE49267B1 - N-substituted aziridine-2-carboxylic acid derivatives - Google Patents

N-substituted aziridine-2-carboxylic acid derivatives

Info

Publication number
IE49267B1
IE49267B1 IE327/80A IE32780A IE49267B1 IE 49267 B1 IE49267 B1 IE 49267B1 IE 327/80 A IE327/80 A IE 327/80A IE 32780 A IE32780 A IE 32780A IE 49267 B1 IE49267 B1 IE 49267B1
Authority
IE
Ireland
Prior art keywords
radical
general formula
cyano
aziridine
substituted
Prior art date
Application number
IE327/80A
Other languages
English (en)
Other versions
IE800327L (en
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IE800327L publication Critical patent/IE800327L/xx
Publication of IE49267B1 publication Critical patent/IE49267B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IE327/80A 1979-02-21 1980-02-20 N-substituted aziridine-2-carboxylic acid derivatives IE49267B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792906603 DE2906603A1 (de) 1979-02-21 1979-02-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
IE800327L IE800327L (en) 1980-08-21
IE49267B1 true IE49267B1 (en) 1985-09-04

Family

ID=6063481

Family Applications (1)

Application Number Title Priority Date Filing Date
IE327/80A IE49267B1 (en) 1979-02-21 1980-02-20 N-substituted aziridine-2-carboxylic acid derivatives

Country Status (19)

Country Link
US (2) US4397848A (OSRAM)
EP (1) EP0014976B1 (OSRAM)
JP (1) JPS55113760A (OSRAM)
AR (1) AR223863A1 (OSRAM)
AT (1) ATE818T1 (OSRAM)
AU (1) AU529982B2 (OSRAM)
CA (1) CA1148962A (OSRAM)
CS (1) CS208798B2 (OSRAM)
DD (1) DD148772A5 (OSRAM)
DE (2) DE2906603A1 (OSRAM)
ES (1) ES488656A1 (OSRAM)
FI (1) FI70702C (OSRAM)
HU (1) HU182801B (OSRAM)
IE (1) IE49267B1 (OSRAM)
IL (1) IL59425A (OSRAM)
PL (1) PL129707B1 (OSRAM)
PT (1) PT70847A (OSRAM)
SU (1) SU1181541A3 (OSRAM)
ZA (1) ZA80902B (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構
ATE252381T1 (de) * 1997-06-27 2003-11-15 Amplimed Inc Neue cyanoaziridine zur behandlung von krebs
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
WO2002041871A2 (en) * 2000-11-21 2002-05-30 Board Of Regents, The University Of Texas System Composition comprising an imexon or derivatives thereof and lipids
CA2466868C (en) * 2001-12-21 2010-06-22 Shire Laboratories Inc. Oral capsule formulation with increased physical stability
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
CN102558155A (zh) 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
DK1606282T3 (da) * 2003-02-24 2009-03-16 Arena Pharm Inc Phenyl- og pyridylpipereidinye-derivater som modulatorer af glucosemetabolisme
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
DE602005011279D1 (de) * 2004-06-04 2009-01-08 Arena Pharm Inc Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
MY148521A (en) * 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
RS20080112A (sr) * 2005-09-16 2009-05-06 Arena Pharmaceuticals Inc., Modulatori metabolizma i lečenje poremećaja koji su vezi sa njima
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
JP5856980B2 (ja) 2010-01-27 2016-02-10 アリーナ ファーマシューティカルズ， インコーポレイテッド （Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸およびその塩の調製のためのプロセス
EP3323818A1 (en) 2010-09-22 2018-05-23 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP4445956A3 (en) 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
EP3310760B8 (en) 2015-06-22 2022-10-19 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in s1p1 receptor-associated disorders
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
KR102859841B1 (ko) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
CN113816887A (zh) * 2021-08-31 2021-12-21 华中科技大学 一种氮杂环丙烷类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644820A1 (de) * 1976-10-05 1978-04-06 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2731264A1 (de) 1977-07-11 1979-02-01 Boehringer Mannheim Gmbh Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Also Published As

Publication number Publication date
SU1181541A3 (ru) 1985-09-23
FI70702C (fi) 1986-10-06
DE2906603A1 (de) 1980-09-04
FI70702B (fi) 1986-06-26
FI800510A7 (fi) 1980-08-22
ES488656A1 (es) 1980-09-16
DD148772A5 (de) 1981-06-10
IL59425A (en) 1984-05-31
IL59425A0 (en) 1980-05-30
PL129707B1 (en) 1984-06-30
US4517183A (en) 1985-05-14
EP0014976B1 (de) 1982-04-07
DE3060268D1 (en) 1982-05-19
EP0014976A1 (de) 1980-09-03
US4397848A (en) 1983-08-09
ATE818T1 (de) 1982-04-15
AU5564980A (en) 1980-08-28
PL222088A1 (OSRAM) 1980-12-01
JPH0150700B2 (OSRAM) 1989-10-31
CA1148962A (en) 1983-06-28
JPS55113760A (en) 1980-09-02
AR223863A1 (es) 1981-09-30
CS208798B2 (en) 1981-09-15
IE800327L (en) 1980-08-21
AU529982B2 (en) 1983-06-30
HU182801B (en) 1984-03-28
PT70847A (de) 1980-03-01
ZA80902B (en) 1981-03-25

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