IE43449L - Improving the compatability of gamma globulins. - Google Patents

Improving the compatability of gamma globulins.

Info

Publication number
IE43449L
IE43449L IE752826A IE282675A IE43449L IE 43449 L IE43449 L IE 43449L IE 752826 A IE752826 A IE 752826A IE 282675 A IE282675 A IE 282675A IE 43449 L IE43449 L IE 43449L
Authority
IE
Ireland
Prior art keywords
gamma globulin
solution
compatability
centrifuged
precipitated
Prior art date
Application number
IE752826A
Other versions
IE43449B1 (en
Original Assignee
Plasmesco Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plasmesco Ag filed Critical Plasmesco Ag
Publication of IE43449L publication Critical patent/IE43449L/en
Publication of IE43449B1 publication Critical patent/IE43449B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1495159 Gamma globulin PLASMESCO AG 29 Dec 1975 [2 Jan 1975] 53020/75 Heading A5B [Also in Division C3] The compatability of gamma globulin precipitated from blood or blood products is improved by dissolving the precipitated gamma globulin in an aqueous solution containing from 1 to 30% of a hydroxyethyl starch having a molecular weight of 1000 to 900000 and thereafter recovering the gamma globulin from this solution. In an example gamma globulin precipitate is dissolved in a buffered aqueous solution at pH 6.7 in a concentration of about 6%. About 10% of hydroxyethyl starch (M.W. 1000 to 900000) is added to this solution which facilitates separation of existing gamma globulin aggregates and simultaneously protects non-aggregated gamma globulin molecules. After addition of 10% of polyethyleneglycol the mixture is centrifuged. The remaining supernatant phase is mixed with 20% polyethylene glycol at pH 7.2 and centrifuged. The resulting precipitate is taken up in saline solution and is suitable for the therapeutic use. [GB1495159A]
IE2826/75A 1975-01-02 1975-12-30 Process reducing the anticomplementary activity of gamma globulins IE43449B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2500076A DE2500076C3 (en) 1975-01-02 1975-01-02 Process for the production of intravenously tolerated gamma globulins

Publications (2)

Publication Number Publication Date
IE43449L true IE43449L (en) 1976-07-02
IE43449B1 IE43449B1 (en) 1981-02-25

Family

ID=5935911

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2826/75A IE43449B1 (en) 1975-01-02 1975-12-30 Process reducing the anticomplementary activity of gamma globulins

Country Status (20)

Country Link
JP (1) JPS5512001B2 (en)
AT (1) AT344883B (en)
AU (1) AU505416B2 (en)
BE (1) BE837211A (en)
CA (1) CA1058075A (en)
DD (1) DD121875A5 (en)
DE (1) DE2500076C3 (en)
DK (1) DK144679C (en)
EG (1) EG11987A (en)
ES (1) ES443982A1 (en)
FR (1) FR2296429A1 (en)
GB (1) GB1495159A (en)
IE (1) IE43449B1 (en)
IL (1) IL48766A (en)
IN (1) IN143525B (en)
NL (1) NL179824C (en)
PL (1) PL99599B1 (en)
SE (1) SE437470B (en)
SU (1) SU576898A3 (en)
ZA (1) ZA758050B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604759C2 (en) * 1976-02-07 1983-06-01 SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld Method of Obtaining IV Compatible Gamma Globulins
JPS6016406B2 (en) * 1976-08-06 1985-04-25 マイヤ−、ル−イス、コ−バル Method for producing intravenously administrable gamma globulin and gamma globulin prepared thereby
US4124576A (en) * 1976-12-03 1978-11-07 Coval M L Method of producing intravenously injectable gamma globulin
GB1603244A (en) * 1977-05-20 1981-11-18 Max Planck Gesellschaft Medicaments for the suppression of pathological processes
JPS5822085B2 (en) * 1977-07-19 1983-05-06 株式会社ミドリ十字 Intravenous gamma globulin preparations
AT359641B (en) * 1978-09-19 1980-11-25 Immuno Ag METHOD FOR PRODUCING AN INTRAVENOUS ADMINISTRABLE ANTIBODY-CONTAINING IMMUNOGLOBULIN PREPARATE
EP0019403B1 (en) * 1979-05-10 1985-07-31 American Hospital Supply Corporation Hydroxyalkyl-starch drug carrier
US4396608A (en) * 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
EP0085747B2 (en) * 1982-02-08 1990-05-30 Schweizerisches Serum- und Impfinstitut und Institut zur Erforschung der Infektionskrankheiten Intravenously administrable human immunoglobuline and process for its preparation
US4482483A (en) * 1983-04-06 1984-11-13 Armour Pharmceutical Company Composition of intravenous immune globulin
SE8302483L (en) * 1983-05-02 1984-11-03 Pharmacia Ind PROCEDURE FOR PURIFICATION OF BIOLOGICALLY ACTIVE SUBSTANCES
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
DE19907257A1 (en) * 1999-02-21 2000-09-14 Bernd Horst Meier Means for controlling the diffusion of injection solutions
DE10040707A1 (en) * 2000-08-17 2002-03-14 Braun Melsungen Ag Injectable aqueous medicament, containing colloid, e.g. hydroxyethyl starch, to modulate mobility, diffusion, pharmacokinetic and electrophoretic properties of active agent and improve effectiveness
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
PT2289909E (en) 2005-11-30 2015-02-10 Abbvie Inc Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies
KR20140087058A (en) 2005-11-30 2014-07-08 애브비 인코포레이티드 Monoclonal antibodies against amyloid beta protein and uses thereof
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
ES2684475T3 (en) 2010-04-15 2018-10-03 Abbvie Inc. Proteins that bind to beta amyloid
MX358739B (en) 2010-08-14 2018-09-03 Abbvie Inc Star Amyloid-beta binding proteins.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE348942B (en) * 1970-06-02 1972-09-18 Statens Bakteriologiska Labor
DE2234069A1 (en) * 1971-07-16 1973-02-08 South African Inventions METHOD OF MANUFACTURING A PURIFIED GAMMA GLOBULIN
IL43643A (en) * 1972-11-27 1976-10-31 Baxter Laboratories Inc Method for production of gamma globulin
JPS49101516A (en) * 1973-01-13 1974-09-25

Also Published As

Publication number Publication date
JPS5191321A (en) 1976-08-10
IE43449B1 (en) 1981-02-25
ATA981675A (en) 1977-12-15
DE2500076C3 (en) 1982-11-18
IL48766A0 (en) 1976-02-29
IN143525B (en) 1977-12-17
EG11987A (en) 1981-12-31
NL7514627A (en) 1976-07-06
DK144679C (en) 1982-10-11
AU505416B2 (en) 1979-11-22
ES443982A1 (en) 1977-07-16
DD121875A5 (en) 1976-09-05
ZA758050B (en) 1976-12-29
BE837211A (en) 1976-06-30
SU576898A3 (en) 1977-10-15
IL48766A (en) 1979-11-30
SE7514388L (en) 1976-07-05
CA1058075A (en) 1979-07-10
GB1495159A (en) 1977-12-14
FR2296429B1 (en) 1978-12-01
AT344883B (en) 1978-08-10
NL179824C (en) 1986-11-17
DK584375A (en) 1976-07-03
DK144679B (en) 1982-05-10
SE437470B (en) 1985-03-04
JPS5512001B2 (en) 1980-03-29
DE2500076A1 (en) 1976-07-08
PL99599B1 (en) 1978-07-31
FR2296429A1 (en) 1976-07-30
DE2500076B2 (en) 1979-02-22
AU8792175A (en) 1977-07-14
NL179824B (en) 1986-06-16

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