SE7514388L - PROCEDURE FOR IMPROVING THE INTROVENOSTOLERANCE OF GAMMA GLOBULINS - Google Patents
PROCEDURE FOR IMPROVING THE INTROVENOSTOLERANCE OF GAMMA GLOBULINSInfo
- Publication number
- SE7514388L SE7514388L SE7514388A SE7514388A SE7514388L SE 7514388 L SE7514388 L SE 7514388L SE 7514388 A SE7514388 A SE 7514388A SE 7514388 A SE7514388 A SE 7514388A SE 7514388 L SE7514388 L SE 7514388L
- Authority
- SE
- Sweden
- Prior art keywords
- gamma globulin
- solution
- centrifuged
- precipitated
- hydroxyethyl starch
- Prior art date
Links
- 108010074605 gamma-Globulins Proteins 0.000 title abstract 8
- 229920001612 Hydroxyethyl starch Polymers 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 229940050526 hydroxyethylstarch Drugs 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000010836 blood and blood product Substances 0.000 abstract 1
- 229940125691 blood product Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1495159 Gamma globulin PLASMESCO AG 29 Dec 1975 [2 Jan 1975] 53020/75 Heading A5B [Also in Division C3] The compatability of gamma globulin precipitated from blood or blood products is improved by dissolving the precipitated gamma globulin in an aqueous solution containing from 1 to 30% of a hydroxyethyl starch having a molecular weight of 1000 to 900000 and thereafter recovering the gamma globulin from this solution. In an example gamma globulin precipitate is dissolved in a buffered aqueous solution at pH 6.7 in a concentration of about 6%. About 10% of hydroxyethyl starch (M.W. 1000 to 900000) is added to this solution which facilitates separation of existing gamma globulin aggregates and simultaneously protects non-aggregated gamma globulin molecules. After addition of 10% of polyethyleneglycol the mixture is centrifuged. The remaining supernatant phase is mixed with 20% polyethylene glycol at pH 7.2 and centrifuged. The resulting precipitate is taken up in saline solution and is suitable for the therapeutic use.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2500076A DE2500076C3 (en) | 1975-01-02 | 1975-01-02 | Process for the production of intravenously tolerated gamma globulins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7514388L true SE7514388L (en) | 1976-07-05 |
| SE437470B SE437470B (en) | 1985-03-04 |
Family
ID=5935911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7514388A SE437470B (en) | 1975-01-02 | 1975-12-18 | PROCEDURE FOR RECOVERY OF A PURE GAMMAGLOBULIN PREPARATION TOLERED BY INTRAVENOS ADMINISTRATION |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS5512001B2 (en) |
| AT (1) | AT344883B (en) |
| AU (1) | AU505416B2 (en) |
| BE (1) | BE837211A (en) |
| CA (1) | CA1058075A (en) |
| DD (1) | DD121875A5 (en) |
| DE (1) | DE2500076C3 (en) |
| DK (1) | DK144679C (en) |
| EG (1) | EG11987A (en) |
| ES (1) | ES443982A1 (en) |
| FR (1) | FR2296429A1 (en) |
| GB (1) | GB1495159A (en) |
| IE (1) | IE43449B1 (en) |
| IL (1) | IL48766A (en) |
| IN (1) | IN143525B (en) |
| NL (1) | NL179824C (en) |
| PL (1) | PL99599B1 (en) |
| SE (1) | SE437470B (en) |
| SU (1) | SU576898A3 (en) |
| ZA (1) | ZA758050B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2604759C2 (en) * | 1976-02-07 | 1983-06-01 | SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld | Method of Obtaining IV Compatible Gamma Globulins |
| JPS6016406B2 (en) * | 1976-08-06 | 1985-04-25 | マイヤ−、ル−イス、コ−バル | Method for producing intravenously administrable gamma globulin and gamma globulin prepared thereby |
| US4124576A (en) * | 1976-12-03 | 1978-11-07 | Coval M L | Method of producing intravenously injectable gamma globulin |
| GB1603244A (en) * | 1977-05-20 | 1981-11-18 | Max Planck Gesellschaft | Medicaments for the suppression of pathological processes |
| JPS5822085B2 (en) * | 1977-07-19 | 1983-05-06 | 株式会社ミドリ十字 | Intravenous gamma globulin preparations |
| AT359641B (en) * | 1978-09-19 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING AN INTRAVENOUS ADMINISTRABLE ANTIBODY-CONTAINING IMMUNOGLOBULIN PREPARATE |
| EP0019403B1 (en) * | 1979-05-10 | 1985-07-31 | American Hospital Supply Corporation | Hydroxyalkyl-starch drug carrier |
| US4396608A (en) * | 1981-08-24 | 1983-08-02 | Cutter Laboratories | Intravenously injectable immune serum globulin |
| ATE19735T1 (en) * | 1982-02-08 | 1986-05-15 | Schweiz Serum & Impfinst | INTRAVENOUSLY DELIVERABLE HUMAN IMMUNOGLOBULIN AND METHOD OF PRODUCTION THEREOF. |
| US4482483A (en) * | 1983-04-06 | 1984-11-13 | Armour Pharmceutical Company | Composition of intravenous immune globulin |
| SE8302483L (en) * | 1983-05-02 | 1984-11-03 | Pharmacia Ind | PROCEDURE FOR PURIFICATION OF BIOLOGICALLY ACTIVE SUBSTANCES |
| US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
| DE19907257A1 (en) * | 1999-02-21 | 2000-09-14 | Bernd Horst Meier | Means for controlling the diffusion of injection solutions |
| DE10040707A1 (en) * | 2000-08-17 | 2002-03-14 | Braun Melsungen Ag | Injectable aqueous medicament, containing colloid, e.g. hydroxyethyl starch, to modulate mobility, diffusion, pharmacokinetic and electrophoretic properties of active agent and improve effectiveness |
| DE10303974A1 (en) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid β (1-42) oligomers, process for their preparation and their use |
| KR101667623B1 (en) | 2005-11-30 | 2016-10-19 | 애브비 인코포레이티드 | Monoclonal antibodies against amyloid beta protein and uses thereof |
| PL1954718T3 (en) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| MX336196B (en) | 2010-04-15 | 2016-01-11 | Abbvie Inc | Amyloid-beta binding proteins. |
| MX358739B (en) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Amyloid-beta binding proteins. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE348942B (en) * | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
| DE2234069A1 (en) * | 1971-07-16 | 1973-02-08 | South African Inventions | METHOD OF MANUFACTURING A PURIFIED GAMMA GLOBULIN |
| ZA738779B (en) * | 1972-11-27 | 1974-10-30 | Baxter Laboratories Inc | Production of gamma globulin |
| JPS49101516A (en) * | 1973-01-13 | 1974-09-25 |
-
1975
- 1975-01-02 DE DE2500076A patent/DE2500076C3/en not_active Expired
- 1975-12-16 NL NLAANVRAGE7514627,A patent/NL179824C/en not_active IP Right Cessation
- 1975-12-18 SE SE7514388A patent/SE437470B/en not_active IP Right Cessation
- 1975-12-22 DK DK584375A patent/DK144679C/en active
- 1975-12-23 AT AT981675A patent/AT344883B/en active
- 1975-12-26 FR FR7539814A patent/FR2296429A1/en active Granted
- 1975-12-27 JP JP15974275A patent/JPS5512001B2/en not_active Expired
- 1975-12-29 GB GB53020/75A patent/GB1495159A/en not_active Expired
- 1975-12-29 DD DD190614A patent/DD121875A5/xx unknown
- 1975-12-30 ZA ZA00758050A patent/ZA758050B/en unknown
- 1975-12-30 IL IL48766A patent/IL48766A/en unknown
- 1975-12-30 ES ES443982A patent/ES443982A1/en not_active Expired
- 1975-12-30 IE IE2826/75A patent/IE43449B1/en unknown
- 1975-12-30 CA CA242,734A patent/CA1058075A/en not_active Expired
- 1975-12-30 IN IN2413/CAL/75A patent/IN143525B/en unknown
- 1975-12-30 BE BE6045314A patent/BE837211A/en not_active IP Right Cessation
- 1975-12-30 AU AU87921/75A patent/AU505416B2/en not_active Expired
- 1975-12-30 EG EG775/75A patent/EG11987A/en active
- 1975-12-31 SU SU7502306354A patent/SU576898A3/en active
-
1976
- 1976-01-01 PL PL1976186289A patent/PL99599B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EG11987A (en) | 1981-12-31 |
| IL48766A (en) | 1979-11-30 |
| PL99599B1 (en) | 1978-07-31 |
| JPS5191321A (en) | 1976-08-10 |
| AU8792175A (en) | 1977-07-14 |
| CA1058075A (en) | 1979-07-10 |
| AT344883B (en) | 1978-08-10 |
| AU505416B2 (en) | 1979-11-22 |
| SE437470B (en) | 1985-03-04 |
| GB1495159A (en) | 1977-12-14 |
| FR2296429A1 (en) | 1976-07-30 |
| BE837211A (en) | 1976-06-30 |
| ATA981675A (en) | 1977-12-15 |
| DE2500076C3 (en) | 1982-11-18 |
| FR2296429B1 (en) | 1978-12-01 |
| ES443982A1 (en) | 1977-07-16 |
| NL7514627A (en) | 1976-07-06 |
| NL179824B (en) | 1986-06-16 |
| IL48766A0 (en) | 1976-02-29 |
| DD121875A5 (en) | 1976-09-05 |
| DE2500076B2 (en) | 1979-02-22 |
| IE43449B1 (en) | 1981-02-25 |
| DE2500076A1 (en) | 1976-07-08 |
| ZA758050B (en) | 1976-12-29 |
| DK584375A (en) | 1976-07-03 |
| IE43449L (en) | 1976-07-02 |
| IN143525B (en) | 1977-12-17 |
| NL179824C (en) | 1986-11-17 |
| DK144679C (en) | 1982-10-11 |
| SU576898A3 (en) | 1977-10-15 |
| JPS5512001B2 (en) | 1980-03-29 |
| DK144679B (en) | 1982-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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