IE42679B1 - Process for the purification of pregnancy-specific -glycoprotein - Google Patents
Process for the purification of pregnancy-specific -glycoproteinInfo
- Publication number
- IE42679B1 IE42679B1 IE818/76A IE81876A IE42679B1 IE 42679 B1 IE42679 B1 IE 42679B1 IE 818/76 A IE818/76 A IE 818/76A IE 81876 A IE81876 A IE 81876A IE 42679 B1 IE42679 B1 IE 42679B1
- Authority
- IE
- Ireland
- Prior art keywords
- glycoprotein
- pregnancy
- specific
- phosphate
- apatite
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 26
- 230000035935 pregnancy Effects 0.000 title claims abstract description 15
- 238000000746 purification Methods 0.000 title claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 3
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 3
- 102000003886 Glycoproteins Human genes 0.000 claims description 9
- 108090000288 Glycoproteins Proteins 0.000 claims description 9
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
- 239000010452 phosphate Substances 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000008363 phosphate buffer Substances 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 239000012064 sodium phosphate buffer Substances 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical group [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 1
- 235000011009 potassium phosphates Nutrition 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 abstract description 2
- 239000000284 extract Substances 0.000 abstract description 2
- 210000002826 placenta Anatomy 0.000 abstract description 2
- 210000002700 urine Anatomy 0.000 abstract description 2
- 239000007791 liquid phase Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000037189 immune system physiology Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Analytical Chemistry (AREA)
- Pregnancy & Childbirth (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/569,476 US4065445A (en) | 1971-09-29 | 1975-04-18 | Pregnancy-specific β1 -glycoprotein and process for isolating it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42679L IE42679L (en) | 1976-10-18 |
| IE42679B1 true IE42679B1 (en) | 1980-09-24 |
Family
ID=24275609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE818/76A IE42679B1 (en) | 1975-04-18 | 1976-04-15 | Process for the purification of pregnancy-specific -glycoprotein |
| IE817/76A IE42566B1 (en) | 1975-04-18 | 1976-04-15 | Process for the enrichment of pregnancy-specific -glycoprotein |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE817/76A IE42566B1 (en) | 1975-04-18 | 1976-04-15 | Process for the enrichment of pregnancy-specific -glycoprotein |
Country Status (18)
| Country | Link |
|---|---|
| JP (2) | JPS51133406A (fr) |
| AT (2) | AT344734B (fr) |
| AU (2) | AU503288B2 (fr) |
| BE (2) | BE840913A (fr) |
| CA (2) | CA1065305A (fr) |
| DE (1) | DE2612479A1 (fr) |
| DK (2) | DK173576A (fr) |
| ES (2) | ES446939A1 (fr) |
| FI (2) | FI56184C (fr) |
| FR (2) | FR2307815A1 (fr) |
| GB (2) | GB1541453A (fr) |
| IE (2) | IE42679B1 (fr) |
| IT (1) | IT1060215B (fr) |
| LU (2) | LU74782A1 (fr) |
| NL (2) | NL7603902A (fr) |
| NO (2) | NO145405C (fr) |
| NZ (1) | NZ180619A (fr) |
| SE (2) | SE7604483L (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2720704C2 (de) * | 1977-05-07 | 1986-09-25 | Behringwerke Ag, 3550 Marburg | Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5325030B2 (fr) * | 1972-12-19 | 1978-07-24 |
-
1976
- 1976-03-24 DE DE19762612479 patent/DE2612479A1/de active Pending
- 1976-04-12 ES ES446939A patent/ES446939A1/es not_active Expired
- 1976-04-12 ES ES446944A patent/ES446944A1/es not_active Expired
- 1976-04-13 NL NL7603902A patent/NL7603902A/xx not_active Application Discontinuation
- 1976-04-13 NL NL7603903A patent/NL7603903A/xx not_active Application Discontinuation
- 1976-04-14 FI FI761017A patent/FI56184C/fi not_active IP Right Cessation
- 1976-04-14 DK DK173576A patent/DK173576A/da active IP Right Grant
- 1976-04-14 NO NO761305A patent/NO145405C/no unknown
- 1976-04-14 NO NO761306A patent/NO761306L/no unknown
- 1976-04-14 DK DK173876A patent/DK173876A/da active IP Right Grant
- 1976-04-14 FI FI761016A patent/FI54486C/fi not_active IP Right Cessation
- 1976-04-15 SE SE7604483A patent/SE7604483L/ not_active Application Discontinuation
- 1976-04-15 GB GB15557/76A patent/GB1541453A/en not_active Expired
- 1976-04-15 NZ NZ180619A patent/NZ180619A/xx unknown
- 1976-04-15 AU AU13081/76A patent/AU503288B2/en not_active Expired
- 1976-04-15 SE SE7604484A patent/SE419340B/xx unknown
- 1976-04-15 CA CA250,426A patent/CA1065305A/fr not_active Expired
- 1976-04-15 IE IE818/76A patent/IE42679B1/en unknown
- 1976-04-15 AU AU13082/76A patent/AU503342B2/en not_active Expired
- 1976-04-15 CA CA250,439A patent/CA1065307A/fr not_active Expired
- 1976-04-15 IE IE817/76A patent/IE42566B1/en unknown
- 1976-04-15 GB GB15558/76A patent/GB1541454A/en not_active Expired
- 1976-04-16 FR FR7611367A patent/FR2307815A1/fr active Granted
- 1976-04-16 IT IT22445/76A patent/IT1060215B/it active
- 1976-04-16 FR FR7611372A patent/FR2307816A1/fr active Granted
- 1976-04-16 AT AT284276A patent/AT344734B/de not_active IP Right Cessation
- 1976-04-16 LU LU74782A patent/LU74782A1/xx unknown
- 1976-04-16 AT AT284176A patent/AT344920B/de not_active IP Right Cessation
- 1976-04-16 LU LU74783A patent/LU74783A1/xx unknown
- 1976-04-17 JP JP51044152A patent/JPS51133406A/ja active Granted
- 1976-04-17 JP JP51044151A patent/JPS51133408A/ja active Pending
- 1976-04-20 BE BE166291A patent/BE840913A/fr not_active IP Right Cessation
- 1976-04-20 BE BE166290A patent/BE840912A/fr unknown
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