IE40515L - 7-(ó- amino-arylacetamido)-cephalosporins - Google Patents

7-(ó- amino-arylacetamido)-cephalosporins

Info

Publication number
IE40515L
IE40515L IE741828A IE182874A IE40515L IE 40515 L IE40515 L IE 40515L IE 741828 A IE741828 A IE 741828A IE 182874 A IE182874 A IE 182874A IE 40515 L IE40515 L IE 40515L
Authority
IE
Ireland
Prior art keywords
compound
alkyl
reacting
give
ococh
Prior art date
Application number
IE741828A
Other versions
IE40515B1 (en
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of IE40515L publication Critical patent/IE40515L/en
Publication of IE40515B1 publication Critical patent/IE40515B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1436409 Peptide derivatives of cephalosporins PFIZER Ltd 5 Dec 1974 [13 Sept 1973] 43033/73 Heading C3H [Also in Division C2] Novel cephalosporins I (in which R<SP>1</SP> is phenyl, 2- or 3-thienyl, or 2- furyl, the phenyl and thienyl groups optionally being substituted by one or more of halo, OH, CF 3 or 1-6 C alkyl or alkoxy; R is OH and R<SP>2</SP> is H, OH, OCOCH 3 , OCONH 2 , N-pyridyl, substituted N-pyridyl, azido or heterocyclylthio or R and R<SP>2</SP> together represent an -O- atom ; R<SP>3</SP> is COOH, SO 3 H, COOR<SP>4</SP> or CONR<SP>5</SP>R<SP>6</SP>; R<SP>4</SP> is 1-6 C alkyl, 5-indanyl, naphthyl or phenyl optionally substituted by halo, CF 3 or 1-6C alkyl or alkoxy; R<SP>5</SP> and R<SP>6</SP> are H, 1-6C alkyl or cycloalkyl or NR<SP>5</SP>R<SP>6</SP> is a saturated heterocyclyl group; X is -NR<SP>7</SP>-, R<SP>7</SP> is H, 1-6 C alkyl, 2-6 C alkenyl, or benzyl; alk<SP>1</SP> is -OH 2 - and alk<SP>2</SP> is a 1-3C divalent, saturated aliphatic hydrocarbon radical) and salts thereof are prepared by (1) reacting a compound II with a cyclic anhydride III or IV (in which X is other than -NH-); (2) reacting a compound II with a compound VI or a compound IX (in which X is other than -NH-) or with an acid chloride, activated ester or mixed anhydride of a compound VI or IX; (3) deprotecting a compound I in which X is -NR<SP>7'</SP>-, R<SP>7'</SP> being a protecting group, to give a compound I in which X is NH; (4) reacting a compound I in which R<SP>2</SP> is OCOCH 3 with an appropriate pyridine, sodium azide or heterocyclic thiol to give a compound I in which R<SP>2</SP> is N-pyridyl, azido or heterocyclylthio; (5) reacting a compound I in which R and R<SP>2</SP> are each OH with a mineral acid to give a compound I in which R and R<SP>2</SP> together represent an -O- atom; and (6) hydrolysing a compound I in which R<SP>2</SP> is OCOCH 3 to give a compound I in which R<SP>2</SP> is OH. [GB1436409A]
IE1828/74A 1973-09-13 1974-09-04 Dephalosporin derivatives IE40515B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4303373A GB1436409A (en) 1973-09-13 1973-09-13 Cephalosporin derivatives

Publications (2)

Publication Number Publication Date
IE40515L true IE40515L (en) 1975-03-13
IE40515B1 IE40515B1 (en) 1979-06-20

Family

ID=10427040

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1828/74A IE40515B1 (en) 1973-09-13 1974-09-04 Dephalosporin derivatives

Country Status (18)

Country Link
JP (1) JPS5082085A (en)
AT (1) AT332971B (en)
AU (1) AU7321074A (en)
BE (1) BE819798A (en)
DD (1) DD114087A5 (en)
DE (1) DE2443424A1 (en)
DK (1) DK481674A (en)
FI (1) FI263774A (en)
FR (1) FR2243698B1 (en)
GB (1) GB1436409A (en)
HU (1) HU169118B (en)
IE (1) IE40515B1 (en)
IL (1) IL45636A0 (en)
LU (1) LU70881A1 (en)
NL (1) NL7411847A (en)
NO (1) NO743287L (en)
SE (1) SE7411229L (en)
ZA (1) ZA745779B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5492982A (en) * 1977-12-28 1979-07-23 Dai Ichi Seiyaku Co Ltd Dipeptide-type cephem derivative
YU44832B (en) * 1981-08-03 1991-04-30 Pliva Pharm & Chem Works Process for preparing semisynthetic cephalosporins

Also Published As

Publication number Publication date
FR2243698B1 (en) 1978-07-21
HU169118B (en) 1976-09-28
AU7321074A (en) 1976-03-18
ATA732274A (en) 1976-02-15
ZA745779B (en) 1975-10-29
AT332971B (en) 1976-10-25
IE40515B1 (en) 1979-06-20
DE2443424A1 (en) 1975-04-03
NL7411847A (en) 1975-03-17
IL45636A0 (en) 1974-11-29
SE7411229L (en) 1975-03-14
LU70881A1 (en) 1976-08-19
FR2243698A1 (en) 1975-04-11
DK481674A (en) 1975-05-12
FI263774A (en) 1975-03-14
NO743287L (en) 1975-04-07
DD114087A5 (en) 1975-07-12
BE819798A (en) 1975-03-11
JPS5082085A (en) 1975-07-03
GB1436409A (en) 1976-05-19

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