SE7411229L - - Google Patents
Info
- Publication number
- SE7411229L SE7411229L SE7411229A SE7411229A SE7411229L SE 7411229 L SE7411229 L SE 7411229L SE 7411229 A SE7411229 A SE 7411229A SE 7411229 A SE7411229 A SE 7411229A SE 7411229 L SE7411229 L SE 7411229L
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- alkyl
- reacting
- give
- ococh
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1436409 Peptide derivatives of cephalosporins PFIZER Ltd 5 Dec 1974 [13 Sept 1973] 43033/73 Heading C3H [Also in Division C2] Novel cephalosporins I (in which R<SP>1</SP> is phenyl, 2- or 3-thienyl, or 2- furyl, the phenyl and thienyl groups optionally being substituted by one or more of halo, OH, CF 3 or 1-6 C alkyl or alkoxy; R is OH and R<SP>2</SP> is H, OH, OCOCH 3 , OCONH 2 , N-pyridyl, substituted N-pyridyl, azido or heterocyclylthio or R and R<SP>2</SP> together represent an -O- atom ; R<SP>3</SP> is COOH, SO 3 H, COOR<SP>4</SP> or CONR<SP>5</SP>R<SP>6</SP>; R<SP>4</SP> is 1-6 C alkyl, 5-indanyl, naphthyl or phenyl optionally substituted by halo, CF 3 or 1-6C alkyl or alkoxy; R<SP>5</SP> and R<SP>6</SP> are H, 1-6C alkyl or cycloalkyl or NR<SP>5</SP>R<SP>6</SP> is a saturated heterocyclyl group; X is -NR<SP>7</SP>-, R<SP>7</SP> is H, 1-6 C alkyl, 2-6 C alkenyl, or benzyl; alk<SP>1</SP> is -OH 2 - and alk<SP>2</SP> is a 1-3C divalent, saturated aliphatic hydrocarbon radical) and salts thereof are prepared by (1) reacting a compound II with a cyclic anhydride III or IV (in which X is other than -NH-); (2) reacting a compound II with a compound VI or a compound IX (in which X is other than -NH-) or with an acid chloride, activated ester or mixed anhydride of a compound VI or IX; (3) deprotecting a compound I in which X is -NR<SP>7'</SP>-, R<SP>7'</SP> being a protecting group, to give a compound I in which X is NH; (4) reacting a compound I in which R<SP>2</SP> is OCOCH 3 with an appropriate pyridine, sodium azide or heterocyclic thiol to give a compound I in which R<SP>2</SP> is N-pyridyl, azido or heterocyclylthio; (5) reacting a compound I in which R and R<SP>2</SP> are each OH with a mineral acid to give a compound I in which R and R<SP>2</SP> together represent an -O- atom; and (6) hydrolysing a compound I in which R<SP>2</SP> is OCOCH 3 to give a compound I in which R<SP>2</SP> is OH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4303373A GB1436409A (en) | 1973-09-13 | 1973-09-13 | Cephalosporin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7411229L true SE7411229L (en) | 1975-03-14 |
Family
ID=10427040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7411229A SE7411229L (en) | 1973-09-13 | 1974-09-05 |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5082085A (en) |
| AT (1) | AT332971B (en) |
| AU (1) | AU7321074A (en) |
| BE (1) | BE819798A (en) |
| DD (1) | DD114087A5 (en) |
| DE (1) | DE2443424A1 (en) |
| DK (1) | DK481674A (en) |
| FI (1) | FI263774A (en) |
| FR (1) | FR2243698B1 (en) |
| GB (1) | GB1436409A (en) |
| HU (1) | HU169118B (en) |
| IE (1) | IE40515B1 (en) |
| IL (1) | IL45636A0 (en) |
| LU (1) | LU70881A1 (en) |
| NL (1) | NL7411847A (en) |
| NO (1) | NO743287L (en) |
| SE (1) | SE7411229L (en) |
| ZA (1) | ZA745779B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5492982A (en) * | 1977-12-28 | 1979-07-23 | Dai Ichi Seiyaku Co Ltd | Dipeptide-type cephem derivative |
| YU44832B (en) * | 1981-08-03 | 1991-04-30 | Pliva Pharm & Chem Works | Process for preparing semisynthetic cephalosporins |
-
1973
- 1973-09-13 GB GB4303373A patent/GB1436409A/en not_active Expired
-
1974
- 1974-09-04 IE IE1828/74A patent/IE40515B1/en unknown
- 1974-09-05 SE SE7411229A patent/SE7411229L/xx not_active Application Discontinuation
- 1974-09-06 NL NL7411847A patent/NL7411847A/en not_active Application Discontinuation
- 1974-09-09 FI FI2637/74A patent/FI263774A/fi unknown
- 1974-09-10 IL IL45636A patent/IL45636A0/en unknown
- 1974-09-11 BE BE148421A patent/BE819798A/en unknown
- 1974-09-11 ZA ZA00745779A patent/ZA745779B/en unknown
- 1974-09-11 DE DE2443424A patent/DE2443424A1/en active Pending
- 1974-09-11 LU LU70881A patent/LU70881A1/xx unknown
- 1974-09-11 AT AT732274A patent/AT332971B/en active
- 1974-09-11 AU AU73210/74A patent/AU7321074A/en not_active Expired
- 1974-09-12 FR FR7430877A patent/FR2243698B1/fr not_active Expired
- 1974-09-12 NO NO743287A patent/NO743287L/no unknown
- 1974-09-12 HU HUPI431A patent/HU169118B/hu unknown
- 1974-09-12 DK DK481674A patent/DK481674A/da unknown
- 1974-09-13 DD DD181090A patent/DD114087A5/xx unknown
- 1974-09-13 JP JP49105933A patent/JPS5082085A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2243698A1 (en) | 1975-04-11 |
| DE2443424A1 (en) | 1975-04-03 |
| NL7411847A (en) | 1975-03-17 |
| AU7321074A (en) | 1976-03-18 |
| FR2243698B1 (en) | 1978-07-21 |
| IE40515B1 (en) | 1979-06-20 |
| LU70881A1 (en) | 1976-08-19 |
| AT332971B (en) | 1976-10-25 |
| FI263774A (en) | 1975-03-14 |
| ZA745779B (en) | 1975-10-29 |
| DK481674A (en) | 1975-05-12 |
| NO743287L (en) | 1975-04-07 |
| BE819798A (en) | 1975-03-11 |
| GB1436409A (en) | 1976-05-19 |
| IL45636A0 (en) | 1974-11-29 |
| DD114087A5 (en) | 1975-07-12 |
| ATA732274A (en) | 1976-02-15 |
| HU169118B (en) | 1976-09-28 |
| JPS5082085A (en) | 1975-07-03 |
| IE40515L (en) | 1975-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 7411229-3 |