ES436170A1 - Cephalosporin antibiotics - Google Patents
Cephalosporin antibioticsInfo
- Publication number
- ES436170A1 ES436170A1 ES436170A ES436170A ES436170A1 ES 436170 A1 ES436170 A1 ES 436170A1 ES 436170 A ES436170 A ES 436170A ES 436170 A ES436170 A ES 436170A ES 436170 A1 ES436170 A1 ES 436170A1
- Authority
- ES
- Spain
- Prior art keywords
- esters
- formula
- image
- cephalosporins
- furoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Abstract
Novel substituted 7-(alpha-ureidoacetamido)cephalosporins of the following formula < IMAGE > wherein R' = H or denotes methyl and R+R1 have the meaning defined in Claim 1, are prepared by reacting a compound of the formula II < IMAGE > with furoyl isocyanate or N-(2-furoyl)-N-methylcarbamoyl chloride. The free acids of the formula I, thus obtained, are also converted to their indanyl esters, phthalidyl esters and alkanoyloxymethyl esters having 1-4 C atoms in the alkyl part and, if desired, to their pharmaceutically acceptable salts. The said cephalosporins exhibit a broad spectrum of antibiotic action against gram-positive and gram-negative microorganisms.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45649174A | 1974-04-01 | 1974-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES436170A1 true ES436170A1 (en) | 1977-02-01 |
Family
ID=23812977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES436170A Expired ES436170A1 (en) | 1974-04-01 | 1975-03-31 | Cephalosporin antibiotics |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS50130784A (en) |
| AR (1) | AR209924A1 (en) |
| AT (1) | AT336790B (en) |
| AU (1) | AU7963675A (en) |
| BE (1) | BE827450A (en) |
| BG (1) | BG27235A3 (en) |
| CA (1) | CA1068260A (en) |
| CH (1) | CH614716A5 (en) |
| CS (1) | CS185229B2 (en) |
| DD (1) | DD118882A5 (en) |
| DE (1) | DE2513954A1 (en) |
| DK (1) | DK130275A (en) |
| ES (1) | ES436170A1 (en) |
| FR (1) | FR2265393B1 (en) |
| GB (1) | GB1502342A (en) |
| HU (1) | HU171886B (en) |
| IE (1) | IE42329B1 (en) |
| IL (1) | IL46955A (en) |
| NL (1) | NL7503882A (en) |
| PH (1) | PH12409A (en) |
| PL (1) | PL95575B1 (en) |
| SE (1) | SE7503706L (en) |
| SU (1) | SU584788A3 (en) |
| ZA (1) | ZA752005B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4063019A (en) | 1976-03-30 | 1977-12-13 | E. R. Squibb & Sons, Inc. | [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives |
-
1975
- 1975-03-20 JP JP50034264A patent/JPS50130784A/ja active Pending
- 1975-03-26 DK DK130275A patent/DK130275A/da not_active Application Discontinuation
- 1975-03-27 AU AU79636/75A patent/AU7963675A/en not_active Expired
- 1975-03-27 CH CH401875A patent/CH614716A5/en not_active IP Right Cessation
- 1975-03-28 HU HU75EI00000606A patent/HU171886B/en unknown
- 1975-03-28 IL IL46955A patent/IL46955A/en unknown
- 1975-03-29 PL PL1975179228A patent/PL95575B1/en unknown
- 1975-03-29 DE DE19752513954 patent/DE2513954A1/en not_active Ceased
- 1975-03-29 BG BG7529483A patent/BG27235A3/en unknown
- 1975-03-31 ES ES436170A patent/ES436170A1/en not_active Expired
- 1975-03-31 PH PH16987A patent/PH12409A/en unknown
- 1975-03-31 SU SU7502119549A patent/SU584788A3/en active
- 1975-04-01 BE BE1006566A patent/BE827450A/en not_active IP Right Cessation
- 1975-04-01 CS CS7500002205A patent/CS185229B2/en unknown
- 1975-04-01 AR AR258199A patent/AR209924A1/en active
- 1975-04-01 NL NL7503882A patent/NL7503882A/en not_active Application Discontinuation
- 1975-04-01 CA CA223,505A patent/CA1068260A/en not_active Expired
- 1975-04-01 FR FR7510142A patent/FR2265393B1/fr not_active Expired
- 1975-04-01 SE SE7503706A patent/SE7503706L/xx unknown
- 1975-04-01 GB GB13384/75A patent/GB1502342A/en not_active Expired
- 1975-04-01 AT AT247575A patent/AT336790B/en not_active IP Right Cessation
- 1975-04-01 ZA ZA752005A patent/ZA752005B/en unknown
- 1975-04-01 DD DD185119A patent/DD118882A5/xx unknown
- 1975-04-02 IE IE707/75A patent/IE42329B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL46955A0 (en) | 1975-05-22 |
| DD118882A5 (en) | 1976-03-20 |
| GB1502342A (en) | 1978-03-01 |
| SU584788A3 (en) | 1977-12-15 |
| AR209924A1 (en) | 1977-06-15 |
| SE7503706L (en) | 1975-10-02 |
| HU171886B (en) | 1978-04-28 |
| IE42329B1 (en) | 1980-07-16 |
| AU7963675A (en) | 1976-09-30 |
| IE42329L (en) | 1975-10-01 |
| DK130275A (en) | 1975-10-02 |
| BG27235A3 (en) | 1979-09-14 |
| CA1068260A (en) | 1979-12-18 |
| NL7503882A (en) | 1975-10-03 |
| PH12409A (en) | 1979-02-07 |
| FR2265393A1 (en) | 1975-10-24 |
| CH614716A5 (en) | 1979-12-14 |
| CS185229B2 (en) | 1978-09-15 |
| IL46955A (en) | 1980-01-31 |
| PL95575B1 (en) | 1977-10-31 |
| FR2265393B1 (en) | 1978-07-28 |
| ATA247575A (en) | 1976-09-15 |
| AT336790B (en) | 1977-05-25 |
| JPS50130784A (en) | 1975-10-16 |
| ZA752005B (en) | 1976-11-24 |
| BE827450A (en) | 1975-10-01 |
| DE2513954A1 (en) | 1975-10-02 |
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