IE40423B1 - D-homo-20-keto-pregnanes - Google Patents
D-homo-20-keto-pregnanesInfo
- Publication number
- IE40423B1 IE40423B1 IE2448/74A IE244874A IE40423B1 IE 40423 B1 IE40423 B1 IE 40423B1 IE 2448/74 A IE2448/74 A IE 2448/74A IE 244874 A IE244874 A IE 244874A IE 40423 B1 IE40423 B1 IE 40423B1
- Authority
- IE
- Ireland
- Prior art keywords
- sub
- hydrogen
- homo
- hydroxy
- methyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 101100386054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CYS3 gene Proteins 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 101150035983 str1 gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2360443A DE2360443A1 (de) | 1973-11-30 | 1973-11-30 | D-homo-20-ketopregnane |
| DE19742445161 DE2445161A1 (de) | 1974-09-19 | 1974-09-19 | D-homo-20-ketopregnane ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40423L IE40423L (en) | 1975-05-30 |
| IE40423B1 true IE40423B1 (en) | 1979-05-23 |
Family
ID=25766200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2448/74A IE40423B1 (en) | 1973-11-30 | 1974-11-28 | D-homo-20-keto-pregnanes |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4045574A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5084561A (cg-RX-API-DMAC7.html) |
| AT (1) | AT347611B (cg-RX-API-DMAC7.html) |
| CA (1) | CA1030522A (cg-RX-API-DMAC7.html) |
| CH (1) | CH618183A5 (cg-RX-API-DMAC7.html) |
| DD (1) | DD115659A5 (cg-RX-API-DMAC7.html) |
| DK (1) | DK134348C (cg-RX-API-DMAC7.html) |
| ES (1) | ES432106A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2253512B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1494097A (cg-RX-API-DMAC7.html) |
| IE (1) | IE40423B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL46153A (cg-RX-API-DMAC7.html) |
| NL (1) | NL7415577A (cg-RX-API-DMAC7.html) |
| SE (1) | SE408426B (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879316A (en) * | 1987-02-26 | 1989-11-07 | The University Of Tennessee Research Corporation | Interpenetrating polymer network ion exchange membranes and method for preparing same |
| US6787530B1 (en) | 1996-08-23 | 2004-09-07 | Monash University | Use of pregnane-diones as analgesic agents |
| US20070066579A1 (en) * | 2002-08-16 | 2007-03-22 | White Michael J | 5-androsten-3beta-ol steroid intermediates and processs for their preparation |
| DE60308388T2 (de) * | 2002-08-16 | 2007-09-20 | Pharmacia & Upjohn Co. Llc, Kalamazoo | 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| SMT202100509T1 (it) | 2013-04-17 | 2021-11-12 | Sage Therapeutics Inc | Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia |
| CN117304245A (zh) | 2013-04-17 | 2023-12-29 | 萨奇治疗股份有限公司 | 刺激神经活性的19-去甲类固醇及其使用方法 |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| CA2918735C (en) | 2013-07-19 | 2023-08-01 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| CN105579043B (zh) | 2013-08-23 | 2021-09-14 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物和其用途 |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| US20170233433A1 (en) | 2014-10-16 | 2017-08-17 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| MY190408A (en) | 2014-10-16 | 2022-04-21 | Sage Therapeutics Inc | Compositions and methods for treating cns disorders |
| WO2016082789A1 (en) | 2014-11-27 | 2016-06-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| LT3250210T (lt) | 2015-01-26 | 2021-04-12 | Sage Therapeutics, Inc. | Kompozicijos ir būdai, skirti gydyti cns sutrikimus |
| DK3258939T3 (da) | 2015-02-20 | 2022-12-12 | Sage Therapeutics Inc | Neuroaktive steroider, sammensætninger og anvendelser heraf |
| WO2018013613A1 (en) | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | C17, c20, and c21 substituted neuroactive steroids and their methods of use |
| CA3030420C (en) | 2016-07-11 | 2025-11-18 | Sage Therapeutics, Inc. | C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE |
| EP3728285B1 (en) * | 2017-12-22 | 2026-04-08 | Sage Therapeutics, LLC | Compositions and methods for treating cns disorders |
| IL312610B2 (en) | 2018-12-05 | 2026-05-01 | Sage Therapeutics Llc | Neuroactive steroids and methods of using them |
| CN111410678B (zh) | 2019-01-08 | 2023-02-28 | 成都康弘药业集团股份有限公司 | 甾体类化合物、用途及其制备方法 |
| JP7670626B2 (ja) | 2019-05-31 | 2025-04-30 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド及びその組成物 |
| BR112021026447A2 (pt) * | 2019-06-27 | 2022-04-12 | Sage Therapeutics Inc | Composições e métodos para tratamento de distúrbios de cns |
| JP7787635B2 (ja) | 2019-06-27 | 2025-12-17 | セージ セラピューティクス， エルエルシー | Ｃｎｓ障害を治療するための組成物及び方法 |
| CA3143545A1 (en) * | 2019-06-27 | 2020-12-30 | Sage Therapeutics, Inc. | Compounds for treating cns disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2860158A (en) * | 1954-10-18 | 1958-11-11 | Sterling Drug Inc | Compounds of the perhydrochrysene series and preparation thereof |
| US3686223A (en) * | 1968-12-26 | 1972-08-22 | Sterling Drug Inc | D-homoestratrienes |
| US3833621A (en) * | 1972-03-20 | 1974-09-03 | Richardson Merrell Inc | 3-keto-7(alpha,beta)-loweralkyl-delta5 steroids and process for preparing same |
-
1974
- 1974-11-20 ES ES432106A patent/ES432106A1/es not_active Expired
- 1974-11-20 DK DK604174A patent/DK134348C/da active
- 1974-11-25 GB GB51006/74A patent/GB1494097A/en not_active Expired
- 1974-11-27 AT AT950774A patent/AT347611B/de not_active IP Right Cessation
- 1974-11-28 CH CH1580574A patent/CH618183A5/de not_active IP Right Cessation
- 1974-11-28 IE IE2448/74A patent/IE40423B1/xx unknown
- 1974-11-28 SE SE7414960A patent/SE408426B/xx unknown
- 1974-11-28 DD DD182648A patent/DD115659A5/xx unknown
- 1974-11-29 IL IL46153A patent/IL46153A/xx unknown
- 1974-11-29 JP JP49137657A patent/JPS5084561A/ja active Pending
- 1974-11-29 US US05/528,328 patent/US4045574A/en not_active Expired - Lifetime
- 1974-11-29 NL NL7415577A patent/NL7415577A/xx not_active Application Discontinuation
- 1974-12-02 CA CA215,097A patent/CA1030522A/en not_active Expired
- 1974-12-02 FR FR7439371A patent/FR2253512B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK604174A (cg-RX-API-DMAC7.html) | 1975-07-28 |
| GB1494097A (en) | 1977-12-07 |
| FR2253512B1 (cg-RX-API-DMAC7.html) | 1978-02-03 |
| IL46153A (en) | 1979-01-31 |
| DK134348B (da) | 1976-10-25 |
| FR2253512A1 (cg-RX-API-DMAC7.html) | 1975-07-04 |
| DK134348C (da) | 1977-03-21 |
| IL46153A0 (en) | 1975-02-10 |
| US4045574A (en) | 1977-08-30 |
| NL7415577A (nl) | 1975-06-03 |
| JPS5084561A (cg-RX-API-DMAC7.html) | 1975-07-08 |
| DD115659A5 (cg-RX-API-DMAC7.html) | 1975-10-12 |
| SE408426B (sv) | 1979-06-11 |
| AU7586774A (en) | 1976-06-03 |
| ATA950774A (de) | 1978-05-15 |
| IE40423L (en) | 1975-05-30 |
| CH618183A5 (cg-RX-API-DMAC7.html) | 1980-07-15 |
| SE7414960L (cg-RX-API-DMAC7.html) | 1975-06-02 |
| AT347611B (de) | 1979-01-10 |
| ES432106A1 (es) | 1976-11-01 |
| CA1030522A (en) | 1978-05-02 |
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