IE38961B1 - Benzylamine derivatives - Google Patents

Benzylamine derivatives

Info

Publication number
IE38961B1
IE38961B1 IE01888/73A IE188873A IE38961B1 IE 38961 B1 IE38961 B1 IE 38961B1 IE 01888/73 A IE01888/73 A IE 01888/73A IE 188873 A IE188873 A IE 188873A IE 38961 B1 IE38961 B1 IE 38961B1
Authority
IE
Ireland
Prior art keywords
formula
action
benzylamine derivatives
gb1450702a
secretolytic
Prior art date
Application number
IE01888/73A
Other versions
IE38961L (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19722251891 external-priority patent/DE2251891C3/en
Priority claimed from DE2316325A external-priority patent/DE2316325A1/en
Priority claimed from DE19732337932 external-priority patent/DE2337932A1/en
Priority claimed from DE2346743A external-priority patent/DE2346743C3/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IE38961L publication Critical patent/IE38961L/en
Publication of IE38961B1 publication Critical patent/IE38961B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Novel benzylamines of the formula I <IMAGE> in which the symbols R1 to R4, Hal and @ have the meaning given in Patent Claim 1, are prepared by introducing the group R2 or R4 into an appropriate secondary amine by the methods of N-alkylation. The compounds of the formula I and their physiologically tolerable acid addition salts with inorganic or organic acids have useful pharmacological properties, in particular a secretolytic and antitussive action in addition to an intensifying action on the production of the surfactant or anti-atelectasis factor of the alveoli. [GB1450702A]
IE01888/73A 1972-10-23 1973-10-22 Benzylamine derivatives IE38961B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19722251891 DE2251891C3 (en) 1972-10-23 Benzylamines, their physiologically acceptable salts, processes for their preparation and pharmaceuticals containing them
DE2316325A DE2316325A1 (en) 1972-10-23 1973-04-02 Halo-hydroxy-substd-benzylamines - as secretolytic and antitussive agents
DE19732320967 DE2320967C3 (en) 1973-04-26 New benzylamines, their physiologically acceptable salts, processes for their production and pharmaceuticals containing them
DE19732337932 DE2337932A1 (en) 1972-10-23 1973-07-26 N-substd. hydroxy-benzylamines prepn - by e.g. reacting benzyl alcohol derivs. with amines
DE2346743A DE2346743C3 (en) 1972-10-23 1973-09-17 2- or 4-Hydroxy-3,5-dihalogenobenzylamines, their physiologically tolerable salts, processes for their preparation and medicaments containing them

Publications (2)

Publication Number Publication Date
IE38961L IE38961L (en) 1974-04-23
IE38961B1 true IE38961B1 (en) 1978-07-05

Family

ID=27510276

Family Applications (1)

Application Number Title Priority Date Filing Date
IE01888/73A IE38961B1 (en) 1972-10-23 1973-10-22 Benzylamine derivatives

Country Status (16)

Country Link
JP (1) JPS5535374B2 (en)
AT (1) AT330149B (en)
BE (1) BE806375A (en)
CA (1) CA1092113A (en)
CH (11) CH602576A5 (en)
DD (1) DD108974A5 (en)
DK (1) DK149883C (en)
FI (1) FI62051C (en)
FR (1) FR2203639B1 (en)
GB (1) GB1450702A (en)
HU (1) HU168131B (en)
IE (1) IE38961B1 (en)
NL (1) NL180978C (en)
NO (1) NO138251C (en)
SE (1) SE409699B (en)
SU (1) SU530638A3 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT332863B (en) * 1973-01-02 1976-10-25 Gerot Pharmazeutika PROCESS FOR THE PREPARATION OF NEW 2-AMINOMETHYL-4,6-DIHALOGENPHENOL DERIVATIVES AND THEIR ADDITIONAL SALTS WITH ACIDS
WO1980000561A1 (en) * 1978-09-06 1980-04-03 Sandoz Ag Alpha-alkyl-o-oxy-benzylamin derivatives,preparation thereof and remedies containing them
US4578390A (en) * 1981-12-14 1986-03-25 Merck & Co., Inc. Hydroxybenzylamino derivatives as anti-inflammatory agents
GB8606066D0 (en) * 1986-03-12 1986-04-16 Ici Plc Bromine-containing polyols
DE3820292A1 (en) * 1988-06-15 1990-04-12 Basf Ag AMINOMETHYLPHENOLS AND FUNGICIDES CONTAINING THEM
WO2009004978A1 (en) * 2007-06-29 2009-01-08 Sumitomo Chemical Company, Limited Plant disease control agent, and plant disease control method
CN107074740B (en) * 2014-11-05 2020-11-10 陶氏环球技术有限责任公司 Flame retardant polyols

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB836934A (en) * 1957-10-03 1960-06-09 Monsanto Chemicals Phenolic amino compounds

Also Published As

Publication number Publication date
SU530638A3 (en) 1976-09-30
AU6170273A (en) 1975-04-24
NO138251C (en) 1978-08-02
JPS5535374B2 (en) 1980-09-12
CH603550A5 (en) 1978-08-31
CH602571A5 (en) 1978-07-31
CH605621A5 (en) 1978-10-13
AT330149B (en) 1976-06-10
NL7314216A (en) 1974-04-25
FI62051C (en) 1982-11-10
CH605620A5 (en) 1978-09-29
CH602576A5 (en) 1978-07-31
IE38961L (en) 1974-04-23
CH602575A5 (en) 1978-07-31
SE409699B (en) 1979-09-03
DK149883B (en) 1986-10-20
CH602573A5 (en) 1978-07-31
HU168131B (en) 1976-02-28
JPS4972224A (en) 1974-07-12
CH611871A5 (en) 1979-06-29
FI62051B (en) 1982-07-30
CH597148A5 (en) 1978-03-31
FR2203639B1 (en) 1978-02-03
NL180978C (en) 1987-06-01
CH602572A5 (en) 1978-07-31
BE806375A (en) 1974-04-22
DK149883C (en) 1987-04-27
GB1450702A (en) 1976-09-29
DD108974A5 (en) 1974-10-12
FR2203639A1 (en) 1974-05-17
NL180978B (en) 1987-01-02
NO138251B (en) 1978-04-24
ATA309675A (en) 1975-09-15
CH602574A5 (en) 1978-07-31
CA1092113A (en) 1980-12-23

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