IE37489L - Benzylamine analgesics - Google Patents

Benzylamine analgesics

Info

Publication number
IE37489L
IE37489L IE51873A IE51873A IE37489L IE 37489 L IE37489 L IE 37489L IE 51873 A IE51873 A IE 51873A IE 51873 A IE51873 A IE 51873A IE 37489 L IE37489 L IE 37489L
Authority
IE
Ireland
Prior art keywords
analgesics
benzylamine
epimers
substituents
compounds
Prior art date
Application number
IE51873A
Other versions
IE37489B1 (en
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IE37489L publication Critical patent/IE37489L/en
Publication of IE37489B1 publication Critical patent/IE37489B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula I are obtained by reduction of ketones of the formula C. The cis-epimers are obtained and used directly or after removal of additionally formed trans-epimers. The substituents X, R<1> and R<2> can be converted into other substituents which guarantee the same utility of the substances. The compounds I and their pharmacologically utilisable acid addition salts are suitable as analgesics for vertebrates. <IMAGE> [CH621328A5]
IE51873A 1972-04-06 1973-04-03 Benzylamine analgesics IE37489B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24161372A 1972-04-06 1972-04-06
GB4108672 1972-09-05

Publications (2)

Publication Number Publication Date
IE37489L true IE37489L (en) 1973-10-06
IE37489B1 IE37489B1 (en) 1977-08-03

Family

ID=26264580

Family Applications (1)

Application Number Title Priority Date Filing Date
IE51873A IE37489B1 (en) 1972-04-06 1973-04-03 Benzylamine analgesics

Country Status (11)

Country Link
AR (1) AR210837A1 (en)
CH (2) CH621328A5 (en)
DK (1) DK146563C (en)
EG (1) EG11463A (en)
ES (1) ES413280A1 (en)
FI (1) FI56963C (en)
IE (1) IE37489B1 (en)
NL (1) NL7304856A (en)
PH (1) PH19134A (en)
SE (1) SE400550B (en)
YU (1) YU39296B (en)

Also Published As

Publication number Publication date
AR210837A1 (en) 1977-09-30
DK146563B (en) 1983-11-07
IE37489B1 (en) 1977-08-03
FI56963C (en) 1980-05-12
CH621328A5 (en) 1981-01-30
NL7304856A (en) 1973-10-09
EG11463A (en) 1978-03-29
DK146563C (en) 1984-04-24
FI56963B (en) 1980-01-31
SE400550B (en) 1978-04-03
ES413280A1 (en) 1976-05-01
YU91573A (en) 1982-02-28
YU39296B (en) 1984-10-31
PH19134A (en) 1986-01-10
CH638173A5 (en) 1983-09-15

Similar Documents

Publication Publication Date Title
IE42216L (en) Benzomorphane derivatives
IE41383L (en) Piperidinylimidazolinone derivatives
BG27903A3 (en) Method of obtaining of n-(methoxy-methyl-furilmethil)-6,7- benzomorphanes and-morphinanes and their addition salts with acid
CA1033863A (en) Aqueous coating composition based on acid salts of epoxy-amine adducts
IE41440L (en) Thiatetracyclines
CH613449A5 (en) Process for the preparation of novel indole derivatives
IE45109L (en) N-2-imidazolidinylidene-benzeneamine
IE44069L (en) Noroxymorphones
CA1014564A (en) Derivatives of 1,3-benzodioxole-2-carboxylic acid
GB1243593A (en) Improvements in or relating to alkyl prolines and the manufacture thereof
IE36598L (en) Phthalazone derivatives
IE37489L (en) Benzylamine analgesics
IE44607L (en) Cephalosporin compounds.
IE42933L (en) Glyoxylic acid derivatives.
IE35032B1 (en) Phenyl-azolyl-fatty acid derivatives,process for their production and their use as medicines
IE35052L (en) Indenopyridines.
CA938294A (en) Manufacture of 1,1&#39;-disubstituted-4,4&#39;-bipyridylium salts
IE38745L (en) 1-alkylideneaminouracils
ES449917A1 (en) Substituted indanones
IE38940L (en) Pharmaceutical compositions; salts of p-chlorohippuric acid
IE38320B1 (en) N-(heteroarylmethyl)-desoxy-normorphines and norcodeines
GB1263677A (en) Process for the preparation of quinoxaline-di-n-oxide-aldehyde
ES432744A1 (en) Dibenzyl-glycolic acid derivatives
IL42498A (en) The preparation of 2h-3-isoquinolones
DK137925B (en) Analogous process for the preparation of 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine compounds or acid addition salts thereof.