IE37489L - Benzylamine analgesics - Google Patents

Benzylamine analgesics

Info

Publication number
IE37489L
IE37489L IE51873A IE51873A IE37489L IE 37489 L IE37489 L IE 37489L IE 51873 A IE51873 A IE 51873A IE 51873 A IE51873 A IE 51873A IE 37489 L IE37489 L IE 37489L
Authority
IE
Ireland
Prior art keywords
analgesics
benzylamine
epimers
substituents
compounds
Prior art date
Application number
IE51873A
Other versions
IE37489B1 (en
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IE37489L publication Critical patent/IE37489L/en
Publication of IE37489B1 publication Critical patent/IE37489B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula I are obtained by reduction of ketones of the formula C. The cis-epimers are obtained and used directly or after removal of additionally formed trans-epimers. The substituents X, R<1> and R<2> can be converted into other substituents which guarantee the same utility of the substances. The compounds I and their pharmacologically utilisable acid addition salts are suitable as analgesics for vertebrates. <IMAGE> [CH621328A5]
IE51873A 1972-04-06 1973-04-03 Benzylamine analgesics IE37489B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24161372A 1972-04-06 1972-04-06
GB4108672 1972-09-05

Publications (2)

Publication Number Publication Date
IE37489L true IE37489L (en) 1973-10-06
IE37489B1 IE37489B1 (en) 1977-08-03

Family

ID=26264580

Family Applications (1)

Application Number Title Priority Date Filing Date
IE51873A IE37489B1 (en) 1972-04-06 1973-04-03 Benzylamine analgesics

Country Status (11)

Country Link
AR (1) AR210837A1 (en)
CH (2) CH621328A5 (en)
DK (1) DK146563C (en)
EG (1) EG11463A (en)
ES (1) ES413280A1 (en)
FI (1) FI56963C (en)
IE (1) IE37489B1 (en)
NL (1) NL7304856A (en)
PH (1) PH19134A (en)
SE (1) SE400550B (en)
YU (1) YU39296B (en)

Also Published As

Publication number Publication date
DK146563B (en) 1983-11-07
IE37489B1 (en) 1977-08-03
EG11463A (en) 1978-03-29
SE400550B (en) 1978-04-03
CH621328A5 (en) 1981-01-30
ES413280A1 (en) 1976-05-01
NL7304856A (en) 1973-10-09
YU91573A (en) 1982-02-28
FI56963B (en) 1980-01-31
DK146563C (en) 1984-04-24
AR210837A1 (en) 1977-09-30
YU39296B (en) 1984-10-31
CH638173A5 (en) 1983-09-15
PH19134A (en) 1986-01-10
FI56963C (en) 1980-05-12

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