IE38809L - Pteridine derivatives - Google Patents
Pteridine derivativesInfo
- Publication number
- IE38809L IE38809L IE740176A IE17674A IE38809L IE 38809 L IE38809 L IE 38809L IE 740176 A IE740176 A IE 740176A IE 17674 A IE17674 A IE 17674A IE 38809 L IE38809 L IE 38809L
- Authority
- IE
- Ireland
- Prior art keywords
- amino
- pteridine derivatives
- spiralkyl
- hydroxyacetonyl
- cr1r2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Title compds are formula (I), where R' and R2 are 1-4C alkyl or CR1R2 is a 4-6 membered spiralkyl gp., and are prepd. e.g. by (a) mild oxidation (O2 and I2/H+) of the corresp. 6-hydroxymethyl deriv. or (b) reductive cyclisation of a 2-amino 4-(1,1'-dialkyl-3'-hydroxyacetonyl )amino 6-hydroxy 5-nitro-pyrimidine oxime. (I) inhibits hydroxymethyldihydropteridine pyrophosphokinase, and compsns. with dihydrofolate reductase inhibitors and/or p-aminobenzoic acid competitors are synergistic.
[FR2215963A1]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB518673A GB1468171A (en) | 1973-02-01 | 1973-02-01 | 2-amino-4-hydroxy-7,8-dihydropteridine-6-carboxaldehyde deri vatives |
DK420173AA DK138019B (en) | 1972-08-01 | 1973-07-31 | Analogous process for the preparation of 7,8-dihydropteridines or tautomers or salts thereof. |
DK53174AA DK140667B (en) | 1973-02-01 | 1974-01-31 | Analogous process for the preparation of 7,8-dihydropteridines or tautomeric forms or salts thereof. |
Publications (2)
Publication Number | Publication Date |
---|---|
IE38809L true IE38809L (en) | 1974-08-01 |
IE38809B1 IE38809B1 (en) | 1978-06-07 |
Family
ID=27220757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE176/74A IE38809B1 (en) | 1973-02-01 | 1974-01-31 | "2-amino-4-hydroxy-7,8-dithydropteridine-6-carboxaldehyde derivatives |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS49102695A (en) |
AR (1) | AR205702A1 (en) |
BE (1) | BE810474A (en) |
CA (1) | CA1025855A (en) |
CH (1) | CH601300A5 (en) |
CS (1) | CS183731B2 (en) |
DD (1) | DD110499A5 (en) |
DE (1) | DE2404593A1 (en) |
DK (1) | DK140667B (en) |
ES (1) | ES422825A1 (en) |
FI (1) | FI55663C (en) |
FR (1) | FR2215963A1 (en) |
HU (1) | HU171384B (en) |
IE (1) | IE38809B1 (en) |
IL (1) | IL44123A (en) |
IN (1) | IN139181B (en) |
NL (1) | NL7401350A (en) |
PL (1) | PL91643B1 (en) |
SE (1) | SE415563B (en) |
ZA (1) | ZA74657B (en) |
-
1974
- 1974-01-01 AR AR252155A patent/AR205702A1/en active
- 1974-01-31 JP JP49013252A patent/JPS49102695A/ja active Pending
- 1974-01-31 ZA ZA00740657A patent/ZA74657B/en unknown
- 1974-01-31 DK DK53174AA patent/DK140667B/en unknown
- 1974-01-31 DE DE2404593A patent/DE2404593A1/en not_active Ceased
- 1974-01-31 BE BE140440A patent/BE810474A/en unknown
- 1974-01-31 ES ES422825A patent/ES422825A1/en not_active Expired
- 1974-01-31 DD DD176300A patent/DD110499A5/xx unknown
- 1974-01-31 FR FR7403214A patent/FR2215963A1/en active Granted
- 1974-01-31 FI FI267/74A patent/FI55663C/en active
- 1974-01-31 CS CS7400000661A patent/CS183731B2/en unknown
- 1974-01-31 SE SE7401254A patent/SE415563B/en unknown
- 1974-01-31 IN IN208/CAL/74A patent/IN139181B/en unknown
- 1974-01-31 PL PL1974168470A patent/PL91643B1/pl unknown
- 1974-01-31 HU HU74WE00000499A patent/HU171384B/en unknown
- 1974-01-31 CH CH136274A patent/CH601300A5/xx not_active IP Right Cessation
- 1974-01-31 IL IL44123A patent/IL44123A/en unknown
- 1974-01-31 IE IE176/74A patent/IE38809B1/en unknown
- 1974-01-31 NL NL7401350A patent/NL7401350A/xx not_active Application Discontinuation
- 1974-01-31 CA CA191,502A patent/CA1025855A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
SE415563B (en) | 1980-10-13 |
IL44123A (en) | 1977-10-31 |
BE810474A (en) | 1974-07-31 |
CH601300A5 (en) | 1978-07-14 |
FR2215963B1 (en) | 1976-09-03 |
DE2404593A1 (en) | 1974-08-15 |
AR205702A1 (en) | 1976-05-31 |
DK140667B (en) | 1979-10-22 |
IE38809B1 (en) | 1978-06-07 |
FI55663C (en) | 1979-09-10 |
FR2215963A1 (en) | 1974-08-30 |
IL44123A0 (en) | 1974-05-16 |
IN139181B (en) | 1976-05-15 |
ZA74657B (en) | 1975-09-24 |
DK140667C (en) | 1980-03-24 |
ES422825A1 (en) | 1976-05-01 |
CA1025855A (en) | 1978-02-07 |
DD110499A5 (en) | 1974-12-20 |
JPS49102695A (en) | 1974-09-27 |
CS183731B2 (en) | 1978-07-31 |
AU6513474A (en) | 1975-08-07 |
PL91643B1 (en) | 1977-03-31 |
HU171384B (en) | 1977-12-28 |
FI55663B (en) | 1979-05-31 |
NL7401350A (en) | 1974-08-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU186788A (en) | Process for preparing opticaly active derivatives of benzoxazine | |
MY117352A (en) | Oximesulfonic acid esters and the use thereof as latent sulfonic acids. | |
ES8104233A1 (en) | Quinoline carboxylic acid derivatives | |
MY131501A (en) | Process for the prepration of clavulanic acid | |
IE45597L (en) | Cephalosporins. | |
GB1457078A (en) | Pyrazolo pyridine derivatives | |
IE38886B1 (en) | Heterocyclic compounds | |
EP0324418A3 (en) | Method for production of t-butyl- 3-oxobutyrates and their use | |
IE812420L (en) | Spiro compounds | |
IE40409L (en) | Novel 2,6- disubstituted phenyl-aminoguanidine compounds | |
DE3782347D1 (en) | HETARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS. | |
HU9501727D0 (en) | Novel pyridone carboxylic acid derivatives | |
IE38809L (en) | Pteridine derivatives | |
GB1466493A (en) | 1-h-tetrazole derivatives | |
GB1480003A (en) | Tricyclic dicarboximides | |
HUT58097A (en) | Process for producing 3,7-diazobicyclo(3,3.1)nonane compounds and pharmaceutical compositions comprising same | |
GB1508616A (en) | Glycosyl compounds | |
GB1262993A (en) | NEW s-TRIAZINE DERIVATIVES, THEIR PREPARATION AND USE | |
GB1194598A (en) | Benzofuran Derivatives | |
JPS6442475A (en) | Thiazolidine derivative | |
IE33345L (en) | Isothiazolopyrimidines. | |
GB1345449A (en) | Pyridylpiperazines and process for their preparation | |
GB1457005A (en) | 2-substituted-3-aminoquinoxalines | |
IE43138L (en) | Quinolizines | |
FR2228064A1 (en) | 4-amino-2,6-dihydroxy-(di or tri-alkoxy)-benzyl-pyrimidines - and derivs - intermediates for pharmaceuticals |