FR2215963A1 - Pteridine antimicrobials and bacteriostats - Google Patents
Pteridine antimicrobials and bacteriostatsInfo
- Publication number
- FR2215963A1 FR2215963A1 FR7403214A FR7403214A FR2215963A1 FR 2215963 A1 FR2215963 A1 FR 2215963A1 FR 7403214 A FR7403214 A FR 7403214A FR 7403214 A FR7403214 A FR 7403214A FR 2215963 A1 FR2215963 A1 FR 2215963A1
- Authority
- FR
- France
- Prior art keywords
- amino
- pteridine
- bacteriostats
- antimicrobials
- spiralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Title compds are formula (I), where R' and R2 are 1-4C alkyl or CR1R2 is a 4-6 membered spiralkyl gp., and are prepd. e.g. by (a) mild oxidation (O2 and I2/H+) of the corresp. 6-hydroxymethyl deriv. or (b) reductive cyclisation of a 2-amino 4-(1,1'-dialkyl-3'-hydroxyacetonyl )amino 6-hydroxy 5-nitro-pyrimidine oxime. (I) inhibits hydroxymethyldihydropteridine pyrophosphokinase, and compsns. with dihydrofolate reductase inhibitors and/or p-aminobenzoic acid competitors are synergistic.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB518673A GB1468171A (en) | 1973-02-01 | 1973-02-01 | 2-amino-4-hydroxy-7,8-dihydropteridine-6-carboxaldehyde deri vatives |
| DK420173AA DK138019B (en) | 1972-08-01 | 1973-07-31 | Analogous process for the preparation of 7,8-dihydropteridines or tautomers or salts thereof. |
| DK53174AA DK140667B (en) | 1973-02-01 | 1974-01-31 | Analogous process for the preparation of 7,8-dihydropteridines or tautomeric forms or salts thereof. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2215963A1 true FR2215963A1 (en) | 1974-08-30 |
| FR2215963B1 FR2215963B1 (en) | 1976-09-03 |
Family
ID=27220757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7403214A Granted FR2215963A1 (en) | 1973-02-01 | 1974-01-31 | Pteridine antimicrobials and bacteriostats |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS49102695A (en) |
| AR (1) | AR205702A1 (en) |
| BE (1) | BE810474A (en) |
| CA (1) | CA1025855A (en) |
| CH (1) | CH601300A5 (en) |
| CS (1) | CS183731B2 (en) |
| DD (1) | DD110499A5 (en) |
| DE (1) | DE2404593A1 (en) |
| DK (1) | DK140667B (en) |
| ES (1) | ES422825A1 (en) |
| FI (1) | FI55663C (en) |
| FR (1) | FR2215963A1 (en) |
| HU (1) | HU171384B (en) |
| IE (1) | IE38809B1 (en) |
| IL (1) | IL44123A (en) |
| IN (1) | IN139181B (en) |
| NL (1) | NL7401350A (en) |
| PL (1) | PL91643B1 (en) |
| SE (1) | SE415563B (en) |
| ZA (1) | ZA74657B (en) |
-
1974
- 1974-01-01 AR AR252155A patent/AR205702A1/en active
- 1974-01-31 NL NL7401350A patent/NL7401350A/xx not_active Application Discontinuation
- 1974-01-31 FI FI267/74A patent/FI55663C/en active
- 1974-01-31 CS CS7400000661A patent/CS183731B2/en unknown
- 1974-01-31 HU HU74WE00000499A patent/HU171384B/en unknown
- 1974-01-31 IN IN208/CAL/74A patent/IN139181B/en unknown
- 1974-01-31 BE BE140440A patent/BE810474A/en unknown
- 1974-01-31 IE IE176/74A patent/IE38809B1/en unknown
- 1974-01-31 ZA ZA00740657A patent/ZA74657B/en unknown
- 1974-01-31 SE SE7401254A patent/SE415563B/en unknown
- 1974-01-31 IL IL44123A patent/IL44123A/en unknown
- 1974-01-31 DD DD176300A patent/DD110499A5/xx unknown
- 1974-01-31 JP JP49013252A patent/JPS49102695A/ja active Pending
- 1974-01-31 ES ES422825A patent/ES422825A1/en not_active Expired
- 1974-01-31 DE DE2404593A patent/DE2404593A1/en not_active Ceased
- 1974-01-31 PL PL1974168470A patent/PL91643B1/pl unknown
- 1974-01-31 FR FR7403214A patent/FR2215963A1/en active Granted
- 1974-01-31 CH CH136274A patent/CH601300A5/xx not_active IP Right Cessation
- 1974-01-31 DK DK53174AA patent/DK140667B/en unknown
- 1974-01-31 CA CA191,502A patent/CA1025855A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA74657B (en) | 1975-09-24 |
| HU171384B (en) | 1977-12-28 |
| SE415563B (en) | 1980-10-13 |
| IE38809B1 (en) | 1978-06-07 |
| BE810474A (en) | 1974-07-31 |
| IL44123A0 (en) | 1974-05-16 |
| IE38809L (en) | 1974-08-01 |
| CA1025855A (en) | 1978-02-07 |
| FI55663B (en) | 1979-05-31 |
| FR2215963B1 (en) | 1976-09-03 |
| IN139181B (en) | 1976-05-15 |
| DK140667B (en) | 1979-10-22 |
| CH601300A5 (en) | 1978-07-14 |
| DD110499A5 (en) | 1974-12-20 |
| NL7401350A (en) | 1974-08-05 |
| JPS49102695A (en) | 1974-09-27 |
| CS183731B2 (en) | 1978-07-31 |
| AU6513474A (en) | 1975-08-07 |
| DK140667C (en) | 1980-03-24 |
| AR205702A1 (en) | 1976-05-31 |
| IL44123A (en) | 1977-10-31 |
| FI55663C (en) | 1979-09-10 |
| ES422825A1 (en) | 1976-05-01 |
| PL91643B1 (en) | 1977-03-31 |
| DE2404593A1 (en) | 1974-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |