IE38421L - N-substituted-9-hydroxybenzomorphan derivatives. - Google Patents
N-substituted-9-hydroxybenzomorphan derivatives.Info
- Publication number
- IE38421L IE38421L IE731914A IE191473A IE38421L IE 38421 L IE38421 L IE 38421L IE 731914 A IE731914 A IE 731914A IE 191473 A IE191473 A IE 191473A IE 38421 L IE38421 L IE 38421L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- alkyl
- carbonyl
- substituted
- pyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1431705 N-substituted benzomorphan derivatives BRISTOL-MYERS CO 26 Oct 1973 [26 Oct 1972] 50039/73 Heading C2C [Also in Division A5] Novel compounds L: (in which R<SP>1</SP> is CH#C-CH 2 -; CH 2 =CH-CH 2 -, (CH 3 ) 2 C=CH-CH 2 -, ClCH=CH-CH 2 - or a radical of formula in which R<SP>6</SP> is H or CH 3 ; R<SP>2</SP> is H, 1-6C alkyl, 2-6C acyl, 3- or 4-pyridyl-carbonyl, N-oxidopyridyl-3-carbonyl, #-morpholinoethyl, methoxymethyl, benzylcarbonyl, orN-oxido-pyridyl- 4-carbonyl; R<SP>5</SP> is H, 2-6C acyl, trichloroacetyl or cinnamoyl; R<SP>3</SP> is H, CH 3 , C 2 H 5 , n-C 3 H 7 , allyl or propargyl; and R<SP>4</SP> is 1-6C alkyl, 3-7C alkenyl or alkynyl or a radical in which n is 1-6 and R<SP>10</SP> is H, Cl, Br, F, NO 2 , 1-6C alkyl or alkoxy or NH 2 ) and salts thereof are prepared by (A) reacting a compound XXXXIII: (in which R<SP>7</SP> is 1-6 alkyl) with a compound (in which X is Cl, Br or iodo, Z is CO or CH 2 and W is as defined for R<SP>1</SP> above but in which the alpha-methylene group is missing) in the presence of a base to give a compound XXXXIV: (B) selectively reducing the carbonyl group of compound XXXXIV if Z is CO to produce a compound XXXXV: and when it is desired to produce compounds L in which R<SP>2</SP> is other than R<SP>7</SP> (C) cleaving the ether function of compound XXXXV to give a compound L where R<SP>2</SP> is H and, if desired, converting, by known methods, the compound L where R<SP>2</SP> is H to a compound L where R<SP>2</SP> is other than H. Certain of the reactions described in the examples are depicted in charts I to VII: (Continued on next page.)
[GB1431705A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30104972A | 1972-10-26 | 1972-10-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE38421L true IE38421L (en) | 1974-04-26 |
IE38421B1 IE38421B1 (en) | 1978-03-15 |
Family
ID=23161711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1914/73A IE38421B1 (en) | 1972-10-26 | 1973-10-25 | N-substituted-9/hydroxy-benzomorphan derivatives |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS4993369A (en) |
BE (1) | BE806613A (en) |
CH (2) | CH601249A5 (en) |
DD (1) | DD107684A5 (en) |
DE (1) | DE2353794A1 (en) |
FR (1) | FR2204417B1 (en) |
GB (1) | GB1431705A (en) |
HU (1) | HU168484B (en) |
IE (1) | IE38421B1 (en) |
NL (1) | NL7314758A (en) |
ZA (1) | ZA738049B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2917182B1 (en) * | 2012-11-09 | 2018-01-03 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3639407A (en) * | 1965-05-05 | 1972-02-01 | Geigy Chem Corp | Novel 1 2 3 4 5 6-hexahydro-6-phenyl-2 6-methano-3-benzazocines |
-
1973
- 1973-10-16 ZA ZA738049A patent/ZA738049B/en unknown
- 1973-10-25 HU HUBI484A patent/HU168484B/hu unknown
- 1973-10-25 FR FR7338152A patent/FR2204417B1/fr not_active Expired
- 1973-10-25 IE IE1914/73A patent/IE38421B1/en unknown
- 1973-10-26 JP JP48120054A patent/JPS4993369A/ja active Pending
- 1973-10-26 CH CH1511373A patent/CH601249A5/xx not_active IP Right Cessation
- 1973-10-26 NL NL7314758A patent/NL7314758A/xx not_active Application Discontinuation
- 1973-10-26 DD DD174320*A patent/DD107684A5/xx unknown
- 1973-10-26 CH CH93577A patent/CH602656A5/xx not_active IP Right Cessation
- 1973-10-26 GB GB5003973A patent/GB1431705A/en not_active Expired
- 1973-10-26 BE BE137153A patent/BE806613A/en unknown
- 1973-10-26 DE DE19732353794 patent/DE2353794A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HU168484B (en) | 1976-05-28 |
DE2353794A1 (en) | 1974-05-09 |
AU6165373A (en) | 1975-04-24 |
NL7314758A (en) | 1974-05-01 |
IE38421B1 (en) | 1978-03-15 |
CH602656A5 (en) | 1978-07-31 |
GB1431705A (en) | 1976-04-14 |
ZA738049B (en) | 1974-09-25 |
BE806613A (en) | 1974-04-26 |
FR2204417A1 (en) | 1974-05-24 |
CH601249A5 (en) | 1978-06-30 |
JPS4993369A (en) | 1974-09-05 |
FR2204417B1 (en) | 1977-09-09 |
DD107684A5 (en) | 1974-08-12 |
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