IE37259L - Benzylpyrimidine derivatives - Google Patents

Benzylpyrimidine derivatives

Info

Publication number
IE37259L
IE37259L IE730182A IE18273A IE37259L IE 37259 L IE37259 L IE 37259L IE 730182 A IE730182 A IE 730182A IE 18273 A IE18273 A IE 18273A IE 37259 L IE37259 L IE 37259L
Authority
IE
Ireland
Prior art keywords
antibacterial
feb
salt
benzylpyrimidine derivatives
gb1388213a
Prior art date
Application number
IE730182A
Other versions
IE37259B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE37259L publication Critical patent/IE37259L/en
Publication of IE37259B1 publication Critical patent/IE37259B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Abstract

1388213 Antibacterial medicines F HOFFMANN-LA ROCHE & CO AG 6 Feb 1973 [7 Feb 1972] 5791/73 Heading ASB [Also in Division C2] Antibacterial compositions comprise a sulphonamide or antibiotic or salt thereof and a compound of the formula (R 1-3 =C 1-7 alkyl) or acid addition salt thereof, with or without other (unspecified) active ingredients. The benzylpyrimidines potentiate the antibacterial activity of sulphonamides (e.g N<SP>1</SP>-3, 4-dimethyl-5-isoxazolyl sulphanilamide) and antibiotics (e.g. oxytetracycline). [GB1388213A]
IE182/73A 1972-02-07 1973-02-06 Benzylpyrimidine derivatives and a process for the manufacture thereof IE37259B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22429272A 1972-02-07 1972-02-07

Publications (2)

Publication Number Publication Date
IE37259L true IE37259L (en) 1973-08-07
IE37259B1 IE37259B1 (en) 1977-06-08

Family

ID=22840026

Family Applications (1)

Application Number Title Priority Date Filing Date
IE182/73A IE37259B1 (en) 1972-02-07 1973-02-06 Benzylpyrimidine derivatives and a process for the manufacture thereof

Country Status (15)

Country Link
JP (1) JPS4886880A (en)
KR (1) KR780000029B1 (en)
AR (1) AR195821A1 (en)
AT (1) AT323744B (en)
AU (1) AU5191873A (en)
BE (1) BE795023A (en)
DD (1) DD103644A5 (en)
DE (1) DE2303838C2 (en)
FR (1) FR2181709B1 (en)
GB (2) GB1388213A (en)
IE (1) IE37259B1 (en)
IL (1) IL41463A0 (en)
LU (1) LU66964A1 (en)
NL (1) NL7301650A (en)
ZA (1) ZA73137B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA738760B (en) * 1972-12-21 1974-08-28 Hoffmann La Roche Process for the manufacture of benzyl pyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
CA1084498A (en) * 1977-05-05 1980-08-26 Alexander E. Wick Benzylpyrimidines and process for the preparation thereof
LU77268A1 (en) * 1977-05-05 1979-01-18
DE2910510A1 (en) * 1979-03-16 1980-09-25 Heumann Ludwig & Co Gmbh 2,4-Di:amino-5-benzyl pyrimidine derivs. - are antibacterial cpds., prepd. by acylation of a 2,4-di:amino-5-(4'-hydroxy-benzyl) -pyrimidine cpd.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
FR1453056A (en) * 1964-11-12 1966-04-15 Hoffmann La Roche Process for the preparation of pyrimidine derivatives
DE1620729A1 (en) * 1965-07-08 1970-08-20 Wellcome Found Process for the preparation of substituted benzylpyrimidines
US3715433A (en) * 1969-06-02 1973-02-06 Hoffmann La Roche Growth promotion in swine

Also Published As

Publication number Publication date
ZA73137B (en) 1973-09-26
IE37259B1 (en) 1977-06-08
AU5191873A (en) 1974-08-08
NL7301650A (en) 1973-08-09
FR2181709B1 (en) 1975-10-10
AT323744B (en) 1975-07-25
GB1388214A (en) 1975-03-26
JPS4886880A (en) 1973-11-15
LU66964A1 (en) 1974-09-25
FR2181709A1 (en) 1973-12-07
AR195821A1 (en) 1973-11-09
DE2303838C2 (en) 1982-09-23
IL41463A0 (en) 1973-04-30
DE2303838A1 (en) 1973-08-16
DD103644A5 (en) 1974-02-05
GB1388213A (en) 1975-03-26
KR780000029B1 (en) 1978-03-10
BE795023A (en) 1973-08-06

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